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个人简介

教育经历 1.1992.09-1997.07天津医科大学临床医学本科(统招) 2.2000.09-2003.07天津医科大学病理学和病理生理学硕士毕业 3.2005.09-2008.07天津医科大学肿瘤学博士研究生(统招) 4.2010.04-2011.03美国M.D.Anderson癌症中心访问副教授 5.2011.04-2013.01美国M.D.Anderson癌症中心博士后 工作经历 1.1997.07-2002.12天津武警医学院病理教研室助教 2.2003.01-2005.03天津武警医学院病理教研室讲师 3.2005.04-2007.12天津医科大学附属肿瘤医院病理科讲师 4.2007.12-2013.03天津医科大学附属肿瘤医院病理科副教授 5.2013.03-至今天津人民医院主任医师 承担课题项目 1.c-Myc-Gcn5-HDAC2在调节PGCCs产生红细胞及其成熟过程中的机制,81672426,201701-202012,国家自然科学基金,57万元; 2.缺氧诱导具有干细胞特性的多倍体巨细胞形成及不对称分裂机制,81472729,201501-201812,国家自然科学基金,72万元; 3.结直肠癌患者术后转移预测的早期诊断和防治策略,17ZXMFSY00120,201710-202009,天津市科技重大专项,200万元。 荣誉和奖励 1.大肠癌发生与器官特异性转移机制及干预的研究,2006JB-1-007-R3,天津市科技进步一等奖,第三完成人; 2.双向分化恶性肿瘤血管生成拟态分子机制研究,2004ZR-3-011-R3,天津市自然科学三等奖,第三完成人; 3.多倍体肿瘤巨细胞在肿瘤发生发展过程中的作用及其机制,2016JB-3-084,天津市科技进步三等奖,排名第一; 4.专利:干细胞小球诱导培养液及干细胞小球培养方法,ZL201310286095.3201703,第一申请人。

研究领域

肿瘤转移分子机制研究

近期论文

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1.GaoY,SunW,ShangW,LiY,ZhangD,WangT,ZhangX,ZhangS,ZhangY,YangR.Lnc-C/EBPβNegativelyRegulatestheSuppressiveFunctionofMyeloid-derivedSuppressorCells.CancerImmunolRes.2018Aug31.pii:canimm.0108.2018.doi:10.1158/2326-6066.CIR-18-0108.[Epubaheadofprint] 2.LiuG,WangY,FeiF,WangX,LiC,LiuK,DuJ,CaoY,ZhangS.Clinicalcharacteristicsandpreliminarymorphologicalobservationof47casesofprimaryanorectalmalignantmelanomas.Melanomaresearch.2018 3.LiuG,FeiF,QuJ,WangX,ZhaoY,LiY,ZhangS.iTRAQ-basedproteomicanalysisofDMH-inducedcolorectalcancerinmicerevealstheexpressionsofβ-catenin,decorin,septin-7,andS100A10expressionin53casesofhumanhereditarypolyposiscolorectalcancer.Clinicaltranslationaloncology.2018Jun28.doi:10.1007/s12094-018-1912-6. 4.LiY,CongJ,FeiF,ZhangZ,YuY,XuC,ZhangS.Theuseofhigh-resolutioncolonicmanometrytoestablishetiologyanddirecttreatmentinpatientswithconstipation:caseserieswithcorrelationtohistology.JGastroenterolHepatol.33(2018)1864–1872. 5.ZhangS,FeiF,WangH,GuY,LiC,WangX,ZhaoY,LiY.StromalimmunoglobulinκCexpressionisassociatedwithinitiationofbreastcancerinTA2miceandhumanbreastcancer.CancerScience.2018;109:1825–1833. 6.WangY,ZhangS,XuT,ZhangT,MoY,LiuJ,YanL,XingF.Ultra-sensitiveandultra-fastdetectionofwholeunlabeledlivingcancercellresponsestopaclitaxelwithagraphene-basedbiosensor.SensorsandActuatorsB:Chemical.2018;417–425 7.WangX,FeiF,QuJ,LiC,LiY,ZhangS.Theroleofseptin7inphysiologyandpathologicaldisease:Asystematicreviewofcurrentstatus.JCellMolMed.2018;22:3298–3307. 8.YangZ,YaoH,FeiF,LiY,QuJ,LiC,ZhangS.GenerationofErythroidCellsfromPolyploidGiantCancerCells:Re-ThinkingaboutTumorBloodSupply.JournalofCancerResearchandClinicalOncology,144(4),617-627. 9.FeiFei,JieQu,ChunyuanLi,XinluWang,YuweiLiandShiwuZhang.Roleofmetastasis-inducedproteinS100A4inhumannon-tumorpathophysiologies.Cell&Bioscience2017;7:64 10.ZhongX,WangX,FeiF,ZhangM,DingP,ZhangS.TheMolecularMechanismandNeuroprotectiveEffectofDihydrocapsaicin-InducedMildHypothermiaAfterCardiopulmonaryResuscitationinRats.TherHypothermiaTempManag.TherHypothermiaTempManag.2018Jun;8(2):76-82. 11.LiY,YuY,LiS,ZhangM,ZhangZ,ShiY,ZhangX,ZhangS.iTRAQ-basedproteomicanalysisrevealstherolesofprogesteronereceptor,inflammatoryandfibrosisforslowtransitconstipation.JournalofGastroenterologyandHepatology.2018Feb;33(2):385-392. 12.FeiF,JieQu,MingqingZhang,ChunyunLi,YuweiLi,ShiwuZhang.S100A4incancerprogressionandmetastasis:Asystematicreview.Oncotarget,2017,1-20,2017,Vol.8,(No.42),pp:73219-73239 13.ZhangD,FeiF,LiS,ZhaoY,YangZ,QuJ,ZhangX,YinY,ZhangS.Theroleofβ-cateninintheinitiationandmetastasisofTA2micespontaneousbreastcancer.JournalofCancer.2017;8(11):2114-2123. 14.WangY,ZhangC,ZhangS,ZhaoZ,WangJ,SongJ,WangY,LiuJ,HouS.(2017).KanglaitesensitizescolorectalcancercellstoTaxolviaNF-κΒinhibitionandconnexin43upregulation.SciRep.2017Apr28;7(1):1280.doi:10.1038/s41598-017-01480-2. 15.TangT,YangZ,ZhangD,QuJ,LiuG,ZhangS.Clinicopathologicalstudyof9casesofprostatecancerinvolvingtherectalwall.DiagnosticPathology.2017Jan17;12(1):8. 16.ZhangD,YangX,YangZ,FeiF,LiS,QuJ,ZhangM,LiY,ZhangX,ZhangS.DaughterCellsandErythroidCellsBuddingfromPGCCsandTheirClinicopathologicalSignificancesinColorectalCancer.JCancer2017;8(3):469-478.doi:10.7150/jca.17012. 17.ZhangS,ZhangD,YangZ,ZhangX.TumorBudding,MicropapillaryPattern,andPolyploidyGiantCancerCellsinColorectalCancer:CurrentStatusandFutureProspects.StemCellsInt.2016;4810734.Epub2016Oct23. 18.WangY,ZhangS,ZhangC,ZhaoZ,ZhengX,XueL,LiuJ,YuanXC.InvestigationofanSPRbiosensorfordeterminingtheinfluenceofconnexin43expressiononthecytotoxicityofcisplatin.Analyst.2016May23;141(11):3411-20 19.ZhangS,Mercado-UribeI,SoodA,BastRandLiuJ.Coevolutionofneoplasticepithelialcellsandmultilineagestromaviapolyploidgiantcellsduringimmortalizationandtransformationofmullerianepithelialcells.Genes&Cancer,2016Mar;7(3-4):60–72. 20.YangY,LiuJ,SongF,ZhangS.Theclinicaldiagnosticvalueoftargetbiopsyusingnarrow-bandimagingendoscopyandaccuratelaryngealcarcinomapathologicspecimenacquisition.ClinOtolaryngol.ClinOtolaryngol.2017Feb;42(1):38-45. 21.WangY,ZhangY,ZhangS,ZhaoZ,MinC,LiuJ,YuanX.Anopticaldetectionmethodforanalyzingthecellularresponsetopaclitaxelatthesinglecelllevel.AnalMethods,2016,DOI:10.1039/C6AY00017G 22.FeiF,ZhangD,YangZ,WangS,WangX,WuZ,WuQ*andZhangS.Thenumberofpolyploidgiantcancercellsandepithelial-mesenchymaltransition-relatedproteinsareassociatedwithinvasionandmetastasisinhumanbreastcancer.JournalofExperimental&ClinicalCancerResearch.2015Dec24;34(1):158.doi:10.1186/s13046-015-0277-8. 23.LiuG,WangH,YangZ,TangT,ZhangS.IsItaMetastaticDisease:ACaseReportandNewUnderstandingofRosai-DorfmanDisease?AmericanJournalofDermatopathology.2016;38(6):e72-6. 24.ZhangS,YangC,YangZ,ZhangD,MaX,MillsG,LiuZ.HomeostasisofredoxstatusderivedfromglucosemetabolicpathwaycouldbethekeytounderstandingtheWarburgeffect.AmJCancerRes2015;5(4):1265-1280. 25.ZhangS,XuX,ZhuS,LiuJ.PGCCsGeneratingErythrocytestoFormVMStructureContributestoTumorBloodSupply.BioMedResearchInternational.2015,ID402619. 26.LvH,ShiY,ZhangL,ZhangD,LiuG,YangZ,LiY,FeiF,ZhangS:PolyploidgiantcancercellswithbuddingandtheexpressionofcyclinE,S-phasekinase-associatedprotein2,stathminassociatedwiththegradingandmetastasisinserousovariantumor.BMCCancer2014,14(1):576. 27.ZhangD,WangY,ZhangS.Asymmetriccelldivisioninpolyploidgiantcancercellsandloweukaryoticcells.BioMedResearchInternational.2014,ID432652. 28.ZhangL,DingP,LvH,ZhangD,LiuG,YangZ,LiY,LiuJ,ZhangS.NumberofpolyploidgiantcancercellsandexpressionofEZH2areassociatedwithVMformationandtumorgradeinhumanovariantumor.BioMedResearchInternational.2014,ID903542. 29.WangW,LinP,SunB,ZhangS,CaiW,HanC,LiL,LuH,ZhaoX.Epithelial-MesenchymalTransitionRegulatedbyEphA2ContributestoVasculogenicMimicryFormationofHeadandNeckSquamousCellCarcinoma.BioMedResearchInternational.2014;ID:803914 30.ZhangS,Mercado-UribeI,HanashS,LiuJ.iTRAQ-basedproteomicanalysisofdistinctproteinexpressionpatternsinovarianpolyploidgiantcancercellsandtheirbuddingdaughtercells.Plosone.2013;8(11):e80120. 31.RenL,WangX,DongZ,LiuJ,ZhangS.BonemetastasisfrombreastcancerinvolveselevatedIL-11expressionandthegp130/STAT3pathway.MedOncol.2013;30:634.DOI10.1007/s12032-013-0634-4 32.ZhangS,Mercado-UribeI,LiuJ.TumorstromaanddifferentiatedCellscanbeOriginateddirectlyfromPolyploidGiantCancerCellsInducedbyPaclitaxel.IntJCancer.2013Feb1;134(3):508-18. 33.ZhangS,Mercado-UribeI,SunB,KuangJ,LiuJ*.GenerationofCancerStem-likecellsthroughformationofpolyploidygiantcancercells.Oncogene.2014;33(1):116-28. 34.ZhangS,Mercado-UribeI,LiuJ*.Generationoferythroidcellsbynormalandcancercellsinvitroandinvivo.Cancerlett.2013;333(2):205-12.

学术兼职

1.天津市医师协会病理分会常委 2.天津市病理质控中心副主任委员 3.天津医师协会临床精准医疗专业委员会第一届委员会委员 4.中华医学会天津病理学分会第九届委员 5.北京市肿瘤学会病理分会常委

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