陈元利 - 南开大学

个人简介

教育经历 2009－2014：南开大学，生物化学与分子生物学系，博士 2005－2009：南开大学，生物科学专业，学士工作经历 2014.7-至今南开大学医学院，讲师承担课题项目： 1.中国博士后科学基金面上资助：25-羟胆固醇体内合成自调控与抗病毒功能和机理的研究，项目编号：2015M570226，一等，在研，主持。 2.国家自然科学基金青年科学基金：25-羟基胆固醇体内合成自调控与抗病毒功能和机理的研究，项目编号：31400694，2015年1月-2017年12月。在研，主持。 3.国家自然科学基金面上项目：DNA拓扑异构酶II抑制剂促进动脉粥样硬化斑块消退，项目编号：81473204，2015年1月-2018年12月。在研，参与。讲授课程临床医学留学生《Experimentincellbiology》荣誉和奖励 1.2012年，博士研究生国家奖学金 2.2013年，博士研究生国家奖学金 3.2014年10月，《第十二届全国脂质与脂蛋白学术会议》“阳普杯”青年论文大赛二等奖

研究领域

1.动脉粥样硬化病理机制研究 2.脂代谢与肿瘤 3.非酒精性脂肪肝发病机制和治疗策略

近期论文

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1.LiuM,ZhangW,LiX,HanJ,ChenY*,DuanY*.ImpactofageandsexonthedevelopmentofatherosclerosisandexpressionoftherelatedgenesinapoEdeficientmice.BiochemicalandBiophysicalResearchCommunications.2016;469:456-462. 2.YangX,SunL,LiY,MaC,YangJ,ZhangW,ZhaoB,JiaL,DuanY,HanJ,LiX*,ChenY*.NaoXinTonginhibitstheadvancedatherosclerosisandenhancestheplaquestabilityinapoEdeficientmice.JournalofCardiovascularPharmacology,2016;67:203-211. 3.YangX,YaoH,ChenY,SunL,LiY,MaX,DuanS,LiX,XiangR,HanJ,DuanY*.2015.InhibitionofglutathioneproductioninducesmacrophageCD36expressionandenhancescellularoxLDLuptake.TheJournalofBiologicalChemistry,2015;290:21788-99. 4.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiX,HanJ*,DuanY*.AdministrationofDanhongInjectiontodiabeticdb/dbmiceinhibitsthedevelopmentofdiabeticretinopathyandnephropathy.ScientificReports.2015;5:11219. 5.LiuM,ChenY,ZhangL,WangQ,MaX,LiX,XiangR,ZhuY,QinS,YuY,JiangX,DuanY,HanJ*.RegulationofhepaticcholesterylestertransferproteinexpressionandreversecholesteroltransportbyinhibitionofDNAtopoisomeraseII.TheJournalofBiologicalChemistry2015,290(23):14418-29. 6.ZhangW,WangX,HuW,LiuL,LiX,HanJ,ChenY*,DuanY*.Co-treatmentofpitavastatinanddexamethasoneexacerbatesthehighfatdiet-inducedatherosclerosisinapoE-/-mice.JournalofCardiovascularPharmacology,2015;66:189-95. 7.MaX,LiuY,WangQ,ChenY,LiuM,LiX,XiangR,WeiY,DuanY,HanJ.TamoxifeninducesthedevelopmentofherniainmicebyactivatingMMP-2andMMP-13expression.BiochimicaetBiophysicaActa-MolecularBasisofDisease,2015;1852:1038-1048. 8.ChenY#,DuanY#,YangX,SunL,LiuM,WangQ,MaX,ZhangW,LiX,HuW,MiaoQR,XiangR,HajjarDP,HanJ.InhibitionofERK1/2andactivationofLXRsynergisticallyreduceatheroscleroticlesionsinapoEdeficientmice.ArteriosclerosisThrombosisandVascularBiology,2015;35:948-959. 9.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,HanJ,LiX,DuanY.NaoXinTonginhibitsthedevelopmentofdiabeticretinopathyindb/dbmice.Evidence-BasedComplementaryandAlternativeMedicine,Volume2015;ArticleID242517,8pages,http://dx.doi.org/10.1155/2015/242517. 10.MaX,WangQ,LiuY,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoRQ,DuanY,HanJ.InhibitionoftumorgrowthbyU0126isassociatedwithinductionofinterferon-production.InternationalJournalofCancer2015;136:771-83. 11.WangQ,MaX,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoR,HajjarDP,DuanY,HanJ.Identificationofinterferon-asanewmoleculartargetofliverXreceptor.BiochemicalJournal2014;459:345-354. 12.ChenY#,LiuM#,ZhaoT,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiG,LiX,XiangR,HanJ,DuanY.DanhongInjectioninhibitsthedevelopmentofatherosclerosisinbothApoe-/-andLdlr-/-mice.JournalofcardiovascularPharmacology2014;63:441–452. 13.LiuM#,ChenY#,YangX,ZhangL,ZhaoT,ZhaoB,JiaL,ZhuY,GaoX,ZhangB,LiX,HanJ,DuanY.DanhonginjectioninhibitsthedevelopmentofprimaryabdominalaorticaneurysmsinapoEknockoutmice.ChineseScienceBulletin2014;59:1366-1373. 14.JiangM,ZhangL,MaX,HuW,ChenY,YuM,WangQ,LiX,YinZ,ZhuY,GaoX,HajjarDP,DuanY,HanJ.TamoxifeninhibitsmacrophageFABP4expressionthroughthecombinedeffectsoftheGRandPPARpathways.BiochemicalJournal2013;454:467-477. 15.ZhangL,JiangM,ShuiY,ChenY,WangQ,HuW,MaX,LiX,LiuX,CaoX,LiuM,DuanY,HanJ.DNAtopoisomeraseIIinhibitorsinducemacrophageABCA1expressionandcholesterolefflux---anLXR-dependentmechanism.BBA-MolecularandCellBiologyofLipids2013;1831:1134-45. 16.ChenY,DuanY,KangY,YangX,JiangM,ZhangL,LiG,YinZ,HuW,DongP,LiX,HajjarDP,HanJ.ActivationofliverXreceptorinducesmacrophageinterleukin-5expression.TheJournalofBiologicalChemistry2012;287:43340-50. 17.DuanY#,ChenY#,HuW,LiX,YangX,ZhouX,YinZ,KongD,YaoZ,HajjarDP,LiuL,LiuQ,HanJ.PeroxisomeProliferator-activatedreceptoractivationbyligandsanddephosphorylationinducesproproteinconvertasesubtilisinkexintype9andlowdensitylipoproteinreceptorexpression.TheJournalofBiologicalChemistry2012;287:23667-77. 18.HuW,ZhouX,JiangM,DuanY,ChenY,LiX,YinZ,HeGW,YaoZ,ZhuY,HajjarDP,HanJ.Statinssynergizedexamethasone-inducedadipocytefattyacidbindingproteinexpressioninmacrophages.Atherosclerosis2012;222:434-43. 19.DongP,XieT,ZhouX,HuW,ChenY,DuanY,LiX,HanJ.InductionofmacrophagescavengerreceptortypeBIexpressionbytamoxifenand4-hydroxytamoxifen.Atherosclerosis2011;218:435-42. 20.杨潇潇，刘力沛，孙蕾，李小菊，段亚君，陈元利*.过氧化物酶体增殖物激活受体gamma激动剂和促分裂原活化蛋白激酶1/2抑制剂药物组合对Apoe-/-小鼠动脉粥样硬化发展的抑制作用.中国动脉硬化杂志.2015,23(08):763-768.

学术兼职

中国生物化学与分子生物学会脂蛋白专业委员会青年委员