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个人简介

教育经历 2015.8-2017.7美国范德堡大学医学中心,博士后 2006.8-2011.7美国东卡罗莱纳大学布罗迪医学院解剖与细胞生物学专业,博士 2003.9-2006.6辽宁师范大学生命科学学院细胞生物学专业,硕士 1999.9-2003.6辽宁师范大学生命科学学院生物技术专业,学士 工作经历 2011.8-2017.12南开大学医学院,讲师 2018.1-至今南开大学医学院,副教授 承担课题项目: 1.天津市应用基础及前沿技术研究计划一般项目,肿瘤微环境中的透明质酸对肿瘤干细胞分化特性的影响(项目编号:12JCYBJC30900,起止时间:2012.10-2015.12) 2.国家自然科学基金青年科学基金项目,肿瘤微环境中的透明质酸对乳腺癌干细胞干性的影响(项目编号:81301856,起止时间:2014.01-2016.12) 3.教育部留学回国人员科研启动基金,肿瘤微环境中的透明质酸对肿瘤干细胞分化特性的影响(起止时间:2014.04-2016.12) 4.中央高校基本科研业务费,CD44不同异构体对乳腺癌干细胞自我更新特性的影响(起止时间:2014.04-2014.12) 5.国家自然科学基金面上项目,PTPN2对三阴性乳腺癌患者anti-PD-1/PD-L1反应疗效的影响及机制研究(项目编号:81872325,起止时间:2019.01-2022.12)

研究领域

1.细胞外基质与细胞信号转导 2.肿瘤微环境与肿瘤干细胞的相互影响 3.肿瘤的免疫治疗

近期论文

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1.Gao,R.,Li,D.,Xun,J.,Zhou,W.,Li,J.,Wang,J.,Liu,C.,Li,X.,Shen,W.,Qiao,H.,Stupack,D.G.,andLuo,N.(2018)CD44ICDpromotesbreastcancerstemnessviaPFKFB4-mediatedglucosemetabolism.Theranostics8,6248-6262(共同通讯) 2.Gao,R.,Liu,Y.,Li,D.,Xun,J.,Zhou,W.,Wang,P.,Liu,C.,Li,X.,Shen,W.,Su,W.,Qiao,H.,Stupack,D.G.,andLuo,N.(2018)PFKFB4PromotesBreastCancerMetastasisviaInductionofHyaluronanProductioninap38-DependentManner.Cellularphysiologyandbiochemistry:internationaljournalofexperimentalcellularphysiology,biochemistry,andpharmacology50,2108-2123(共同通讯) 3.Luo,N.,Formisano,L.,Gonzalez-Ericsson,P.I.,Sanchez,V.,Dean,P.T.,Opalenik,S.R.,Sanders,M.E.,Cook,R.S.,Arteaga,C.L.,Johnson,D.B.,andBalko,J.M.(2018)Melanomaresponsetoanti-PD-L1immunotherapyrequiresJAK1signaling,butnotJAK2.Oncoimmunology7,e1438106(第一作者) 4.Luo,N.,Nixon,M.J.,Gonzalez-Ericsson,P.I.,Sanchez,V.,Opalenik,S.R.,Li,H.,Zahnow,C.A.,Nickels,M.L.,Liu,F.,Tantawy,M.N.,Sanders,M.E.,Manning,H.C.,andBalko,J.M.(2018)DNAmethyltransferaseinhibitionupregulatesMHC-ItopotentiatecytotoxicTlymphocyteresponsesinbreastcancer.Naturecommunications9,248(第一作者) 5.Shen,W.,Zhang,X.,Du,R.,Fan,Y.,Luo,D.,Bao,Y.,Yang,W.,Luo,N.,Luo,Y.,andZhao,S.(2018)ICAM3mediatestumormetastasisviaaLFA-1-ICAM3-ERMdependentmanner.Biochimicaetbiophysicaacta.Molecularbasisofdisease1864,2566-2578(共同通讯) 6.Li,J.,Yin,J.,Shen,W.,Gao,R.,Liu,Y.,Chen,Y.,Li,X.,Liu,C.,Xiang,R.,andLuo,N.(2017)TLR4PromotesBreastCancerMetastasisviaAkt/GSK3β/β-CateninPathwayuponLPSStimulation.TheAnatomicalRecord300,1219-1229(共同通讯) 7.Shen,W.,Du,R.,Li,J.,Luo,X.,Zhao,S.,Chang,A.,Zhou,W.,Gao,R.,Luo,D.,Wang,J.,Hao,N.,Liu,Y.,Chen,Y.,Luo,Y.,Sun,P.,Yang,S.,Luo,N.,andXiang,R.(2016)TIFAsuppresseshepatocellularcarcinomaprogressionviaMALT1-dependentand-independentsignalingpathways.SignalTransductionAndTargetedTherapy1,16013(共同通讯) 8.Ai,Q.,Yin,J.,Chen,S.,Qiao,L.,andLuo,N.(2016)Rotavirus-associatedimmunethrombocytopenicpurpurainchildren:Aretrospectivestudy.Experimentalandtherapeuticmedicine12,2187-2190(通讯) 9.Shen,W.,Chang,A.,Wang,J.,Zhou,W.,Gao,R.,Li,J.,Xu,Y.,Luo,X.,Xiang,R.,Luo,N.,andStupack,D.G.(2015)TIFA,aninflammatorysignalingadaptor,istumorsuppressiveforlivercancer.Oncogenesis4,e173(共同通讯) 10.Wang,R.,Zhou,W.,Wang,J.,Liu,Y.,Chen,Y.,Jiang,S.,Luo,X.,Stupack,D.G.,andLuo,N.(2015)RoleofHyaluronanandGlucoseon4-Methylumbelliferone-inhibitedCellProliferationinBreastCarcinomaCells.Anticancerresearch35,4799-4805(共同通讯) 11.Luo,N.,Knudson,W.,Askew,E.B.,Veluci,R.,andKnudson,C.B.(2014)CD44andhyaluronanpromotethebonemorphogeneticprotein7signalingresponseinmurinechondrocytes.Arthritis&rheumatology66,1547-1558(第一作者) 12.Ariyoshi,W.,Knudson,C.B.,Luo,N.,Fosang,A.J.,andKnudson,W.(2010)InternalizationofaggrecanG1domainneoepitopeITEGEinchondrocytesrequiresCD44.TheJournalofbiologicalchemistry285,36216-36224 13.Balko,J.M.,Schwarz,L.J.,Luo,N.,Estrada,M.V.,Giltnane,J.M.,Davila-Gonzalez,D.,Wang,K.,Sanchez,V.,Dean,P.T.,Combs,S.E.,Hicks,D.,Pinto,J.A.,Landis,M.D.,Doimi,F.D.,Yelensky,R.,Miller,V.A.,Stephens,P.J.,Rimm,D.L.,Gomez,H.,Chang,J.C.,Sanders,M.E.,Cook,R.S.,andArteaga,C.L.(2016)Triple-negativebreastcancerswithamplificationofJAK2atthe9p24locusdemonstrateJAK2-specificdependence.Sciencetranslationalmedicine8,334ra353

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