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个人简介

教育经历 1996.9-2001.6中国药科大学理学学士 2003.9-2008.5中国医学科学院协和医科大学博士学位 工作经历 2008-2011南开大学生科院,讲师 2012-2016南开大学生科院,副研究员 2013-2014耶鲁大学,访问学者 2016-至今南开大学医学院,副研究员 主持及参与的科研课题: 1.国家自然科学基金:31771636,Lin28a调控ES细胞naïve-primed状态转变机制研究,2018.1-2021.12主持 2.国家自然科学基金:31000651,印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究,2011.1-2013.12,主持 3.天津市自然科学基金重点项目:14JCZDJC35200,先天性角化不良发病机制探究,2014.3-2017.4,主持 4.中央高校基本科研业务费专项资金:印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究,2010.6-2012.5,主持 5.国家重点研发计划:不同胚层来源器官损伤后再生细胞命运及调控生理性修复的研究,2017.1-2021.8,参与 6.国家重大科学研究计划:端粒相关蛋白在基因表达调控及细胞分化中的作用,2012.1-2016.8,参与 7.国家重大科学研究计划:猪诱导多能干细胞(iPS)及其分化发育研究,2009.1-2013.8,参与 8.天津市自然科学基金重点项目:端粒相关蛋白在多能性干细胞中的作用及调控,2012.4-2015.3,参与 9.国际合作项目:单细胞技术研究肿瘤干细胞标志和新药研发,2013.1-2016.12,参与 讲授课程 1.细胞生物学 2.干细胞与再生医学 荣誉和奖励 1.2012年南开大学教学成果奖二等奖 2.2016年南开大学青年教师教学基本功竞赛二等奖 3.2016年天津市青年教师教学基本功竞赛三等奖

研究领域

干细胞生物学

1.胚胎干细胞多能性维持机制 2.干细胞分化调控机制研究及体内示踪

近期论文

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[1]WangD,SangH,ZhangK,NieY,ZhaoS,ZhangY,HeN,WangY,XuY,XieX,LiZ*,LiuN*.Stat3phosphorylationisrequiredforembryonicstemcellsgroundstatemaintenancein2iculturemedia.Oncotarget.2017;8(19):31227-31237.CorrespondingAuthor [2]LiangL,YueZ,DuW,LiY,TaoH,WangD,WangR,HuangZ,HeN,XieX,HanZ,LiuN*,LiZ*.MolecularImagingofInducibleVEGFExpressionandTumorProgressioninaBreastCancerModel.CellPhysiolBiochem.2017;42(1):407-415.CorrespondingAuthor [3]NieY,ZhangK,ZhangS,WangD,HanZ,CheY,KongD,ZhaoQ,HanZ,HeZX,LiuN*,MaF*,LiZ*.Nitricoxidereleasinghydrogelpromotesendothelialdifferentiationofmouseembryonicstemcells.ActaBiomater.2017;63:190-199.CorrespondingAuthor [4]NingningHe,GuoweiFeng,YangLi,YangXu,XiaoyanXie,HuiWang,YuebingWang,LailiangOu,XuetaoPei,NaLiu*,andZongjinLi*.Embryonicstemcellpreconditionedmicroenvironmentsuppressestumorigenicpropertiesinbreastcancer.StemCellResTher.2016,7(1):95CorrespondingAuthor [5]NaLiu,XinQi,ZhiboHan,LuLiang,DelingKong,ZhongchaoHan,ShihuaZhao,Zuo-XiangHe,andZongjinLi*.BoneMarrowIsaReservoirforCardiacResidentStemCells.SciRep.2016,6:28739.FirstAuthor [6]DanJ#,LiuY#,LiuN#,ChioureaM,OkukaM,WuT,YeX,MouC,WangL,WangL,YinY,YuanJ,ZuoB,WangF,LiZ,PanX,YinZ,ChenL,KeefeDL,GagosS,XiaoA*,LiuL*.Rif1maintainstelomerelengthhomeostasisofESCsbymediatingheterochromatinsilencing.DevCell.2014Apr14;29(1):7-19.FirstAuthor [7]YuYin#,NaLiu#,XiaoyingYe,RenpengGuo,JieHao,FangWang,LinLiu.Telomereelongationinparthenogeneticstemcells.ProteinCell.20145(1):8-11FirstAuthor [8]YinY,WangH,LiuK,WangF,YeX,LiuM,XiangR,LiuN*,LiuL*.,KnockdownofH19enhancesdifferentiationcapacitytoepidermisofparthenogeneticembryonicstemcells.CurrentMolecularMedicine,2014;14(6):737-48.CorrespondingAuthor [9]ZhenrongZhao,XinghuaPan,LinLiu*andNaLiu*.TelomeeLengthMaintenance,Shortening,andLengthening.JCellPhysiol.2014;229(10):1323-9.CorrespondingAuthor [10]NaLiu,LinLiu&XinghuaPan.Single‑cellanalysisofthetranscriptomeanditsapplicationinthecharacterizationofstemcellsandearlyembryos.Cell.Mol.LifeSci.(2014)71:2707–2715FirstAuthor [11]LiuN,EnkemannSA,LiangP,HersmusR,ZanazziC,HuangJ,WuC,ChenZ,LooijengaLH,KeefeDL,LiuL.Genome-wideGeneExpressionProfilingRevealsAberrantMAPKandWntSignalingPathwaysAssociatedwithEarlyParthenogenesis.JMolCellBiol.2010,2(6):333-344.FirstAuthor [12]LiuN,LuM,FengXM,MaFX,FangZH,TianXM,RenQ,ZhangL,LiuB,HuangPP,LiuL,HanZC.ExogenousNanogalleviatesbutisinsufficienttoreverseembryonicstemcellsdifferentiationinducedbyPI3Ksignalinginhibition.JCellBiochem.2009,106(6):1041-1047.FirstAuthor [13]LiuN,FengX,FangZ,MaF,LuS,LuM,HanZ.IdentificationofGenesRegulatedbyNanogWhichIsInvolvedInESCellsPluripotencyandEarlyDifferentiation.JCellBiochem.2008,104(6):2348-2362.FirstAuthor [14]LiuN,LuM,TianX,HanZ.Molecularmechanismsinvolvedinself-renewalandpluripotencyofembryonicstemcells.JCellPhysiol.2007,211(2):279-286.FirstAuthor [15]LiuN,LuM.ThesignaltransductionpathwaysandmoleculesforEScellsself-renewal,ChineseScienceBulletin.2005,50(8):721-726.FirstAuthor 非第一或通讯作者文章 [16]HeN,ChenX,WangD,XuK,WuL,LiuY,TaoH,ZhaoQ,CaoX,LiY,LiuN,QiX,HanZ,KongD,YangJ,LiZ.VE-Cadherinregulatestheself-renewalofmouseembryonicstemcellsviaLIF/Stat3signalingpathway.Biomaterials.2017Dec16;158:34-43. [17]LiuY,SongB,WeiY,ChenF,ChiY,FanH,LiuN,LiZ,HanZ,MaF.Exosomesfrommesenchymalstromalcellsenhanceimatinib-inducedapoptosisinhumanleukemiacellsviaactivationofcaspasesignalingpathway.Cytotherapy.2017Dec18.pii:S1465-3249(17)30733-8. [18]WangR,ZhangK,TaoH,DuW,WangD,HuangZ,ZhouM,XuY,WangY,LiuN,WangH,LiZ.MolecularImagingofTumorAngiogenesisandTherapeuticEffectswithDualBioluminescence.CurrPharmBiotechnol.2017;18(5):422-428. [19]DuW,ZhangK,ZhangS,WangR,NieY,TaoH,HanZ,LiangL,WangD,LiuJ,LiuN,HanZ,KongD,ZhaoQ,LiZ.Enhancedproangiogenicpotentialofmesenchymalstemcell-derivedexosomesstimulatedbyanitricoxidereleasingpolymer.Biomaterials.2017Jul;133:70-81. [20]LiuK,MaoJ,SongL,FanA,ZhangS,WangJ,FanN,LiuN,YeX,FuH,ZhouZ,WangY,WeiH,LiuZ,LiZ,LaiL,WangX,LiuL.DNArepairandreplicationlinkstopluripotencyanddifferentiationcapacityofpigiPScells.PLoSOne.2017Mar2;12(3):e0173047. [21]SongX,LiuD,CuiJ,ZhouM,WangH,LiuN,QiX,LiZ.IdentificationofStem-LikeCellsinAtrialMyxomabyMarkersCD44,CD19,andCD45.StemCellsInt.2016;2016:2059584. [22]GuoweiFeng,JiminZhang,YangLi,YanNie,DashuaiZhu,RanWang,JianfengLiu,JieGao,NaLiu,NingningHe,WeiDu,HongyanTao,YongzheChe,YongXu,DelingKong,QiangZhao,andZongjinLi*.IGF-1CDomain-ModifiedHydrogelEnhancesCellTherapyforAKI.JAmSocNephrol.2016,27(8):2357-69. [23]WangD,MengQ,HuoL,YangM,WangL,ChenX,WangJ,LiZ,YeX,LiuN,LiQ,DaiZ,OuyangH,LiN,ZhouJ,ChenL,LiuL.OverexpressionofHdac6enhancesresistancetovirusinfectioninembryonicstemcellsandinmice.ProteinCell.2015,6(2):152-6. [24]FanN,ChenJ,ShangZ,DouH,JiG,ZouQ,WuL,HeL,WangF,LiuK,LiuN,HanJ,ZhouQ,PanD,YangD,ZhaoB,OuyangZ,LiuZ,ZhaoY,LinL,ZhongC,WangQ,WangS,XuY,LuanJ,LiangY,YangZ,LiJ,LuC,VajtaG,LiZ,OuyangH,WangH,WangY,YangY,LiuZ,WeiH,LuanZ,EstebanMA,DengH,YangH,PeiD,LiN,PeiG,LiuL,DuY,XiaoL,LaiL.Pigletsclonedfrominducedpluripotentstemcells.CellRes.2013,23(1):162-6. [25]YuanJ,ZhangD,WangL,LiuM,MaoJ,YinY,YeX,LiuN,HanJ,GaoY,ChengT,KeefeDL,LiuL.Noevidenceforneo-oogenesismaylinktoovariansenescenceinadultmonkey.StemCells.201331(11):2538-50. [26]JiG,LiuK,OkukaM,LiuN,LiuL.Associationoftelomereinstabilitywithsenescenceofporcinecells.BMCCellBiol.2012Dec15;13:36. [27]ZuoB,YangJ,WangF,WangL,YinY,DanJ,LiuN,LiuL.InfluencesoflaminAlevelsoninductionofpluripotentstemcells.BiolOpen.2012,1(11):1118-27. [28]LiuY,YeX,MaoL,ChengZ,YaoX,JiaX,MaoD,OuL,LiZ,CheY,LiuN,SteinhoffG,LiuL,KongD.Transplantationofparthenogeneticembryonicstemcellsamelioratescardiacdysfunctionandremodellingaftermyocardialinfarction.CardiovascRes.2012,97(2):208-18. [29]LiuJ,LiuM,YeX,LiuK,HuangJ,WangL,JiG,LiuN,TangX,BaltzJM,KeefeDL,LiuL.DelayinoocyteaginginmicebytheantioxidantN-acetyl-L-cysteine(NAC).HumReproduction.2012;27(5):1411-1420. [30]WangF,YinY,YeX,LiuK,ZhuH,WangL,ChioureaM,OkukaM,JiG,DanJ,ZuoB,LiM,ZhangQ,LiuN,ChenL,PanX,GagosS,KeefeDL,LiuL.Molecularinsightsintotheheterogeneityoftelomerereprogrammingininducedpluripotentstemcells.CellResearch.2012;22(4):757-768. [31]HuangJ,WangF,OkukaM,LiuN,JiG,YeX,ZuoB,LiM,LiangP,GeWW,TsibrisJC,KeefeDL,LiuL*.AssociationoftelomerelengthwithauthenticpluripotencyofES/iPScells.CellResearch.2011,21(5):779-92. [32]FangZH,DongCL,ChenZ,ZhouB,LiuN,LanHF,LiangL,LiaoWB,ZhangL,HanZC.Transcriptionalregulationofsurvivinbyc-MycinBCR/ABL-transformedcells:implicationsinanti-leukaemicstrategy.JCellMolMed.200913(8B):2039-52. [33]FengXM,LiuN,YangSG,HuLY,ChenXL,FangZH,RenQ,LuSH,LiuB,HanZC.RegulationoftheclassⅡandclassⅠMHCpathwaysinhumanTHP-1monocyticcellsbyinterleukin-27.BiochemBiophysResCommun.200814;367(3):553-9. [34]FengXM,ChenXL,LiuN,ChenZ,ZhouYL,HanZB,ZhangL,HanZC.Interleukin-27upregulatesmajorhistocompatibilitycomplexclassⅡexpressioninprimaryhumanendoghelialcellsthroughinductionofmajorhistocompatibilitycomplexclassⅡtrasactivator.HumImmunol.200768(12):965-72. BooksandChapters: [1]YinY,LiuN,KeefeD,andLiuL.Parthenogeneticactivation-inducedpluripotentstemcellsandpotentialapplications.StemCellsandCancerStemCells.Volume8.Hayat,MA(edt.)Springer,2012,235-246. [2]YanNie,ShuaiqiangZhang,NaLiu,ZongjinLi,ExtracellularMatrixEnhancesTherapeuticEffectsofStemCellsinRegenerativeMedicine.CompositionandFunctionoftheExtracellularMatrixintheHumanBody.INTECH,2016

学术兼职

1.2010-至今中国细胞生物学学会会员

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