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个人简介

教育经历 2002.9-2008.5美国Rutgers&UniversityofMedicineandDentistryofNewJersey,生理与整合生物专业,博士学位 1993.9-1998.6河南医科大学妇幼专业,医学学士学位 工作经历 2011-至今南开大学医学院,副教授 2008-2011南开大学医学院,讲师 主持的科研课题: 1.国家自然科学基金面上项目“肿瘤干细胞重塑微环境调控新生血管生成的研究”,起止日期2016.1-2019.12,项目负责人 2.国家自然科学基金面上项目“SOX2对IL6R转录调控在肿瘤转移中作用的研究”,起止日期2014.1-2017.12,项目负责人 3.教育部留学回国人员科研启动经费“SOX2在肿瘤转移中作用的研究”,起止日期2012.1-2014.12,项目负责人 4.国家自然科学基金青年基金“SOX2在肿瘤细胞耐药抗凋亡特性中作用的研究”,起止日期2011.1-2013.12,项目负责人 5.中央高校基本科研业务费专项资金“SOX2在与肿瘤转移相关EMT过程中作用的研究”,起止日期2010.6-2012.5,项目负责人 6.教育部高等学校博士学科点专项科研基金“Ca2+-Calcineurin/NFAT信号通路在前列腺癌干细胞中作用的研究”,起止日期2010.1-2012.12,项目负责人 7.国家国际科技合作与交流专项基金“新型乳腺癌早期预警系统的建立及防治方法的合作研究”,起止日期2012.06-2015.05,主要参与人 8.国家科技重大专项项目:CSCs的分离、识别及其分子遗传特征起止日期:2013.3-2016.8,子课题学术骨干 9.天津市科委中瑞合作重点项目“肿瘤转移的分子机制及临床应用研究”,起止日期2009.10-2012.09,主要参与人 讲授课程 1.病理生理学实验 2.病理生理学 3.科研方法论 荣誉和奖励 1.所指导研究生及研究课题“SOX2promotestumormetastasisbystimulatingtheprocessofepithelial-mesenchymaltransition”获得国际会议-102次美国肿瘤年会(2011年)Scholar-in-Training奖励

研究领域

1.探索肿瘤的抗凋亡、耐药复发及转移的相关分子机制; 2.探索肿瘤干细胞与肿瘤微环境之间相互作用的分子机制; 3.肿瘤的靶向治疗; 4.结合DNA疫苗与细胞因子辅助的方法来制定新型的肿瘤治疗策略。

近期论文

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1.SZhao,NBai,JCui,RXiang*andNaLi*PredictionofSurvivalofDiffuse-Large-B-CellLymphomapatientsviatheExpressionofThreeInflammatoryGenes.Cancermedicine2016Aug;5(8):1950-61.*Correspondingauthor 2.YXu,SZhang,HNiu,YYe,FHu,SChen,XLi,YLiu,YChen,JLi,RXiangandNaLi*.STIM1inhibitstumorgrowthbutpromotesthemetastasisofprostatecancerbyremodelingtumormicroenvironmentandenhancingepithelial-to-mesenchymaltransition.ScientificReports2015Aug10;5:11754.*Correspondingauthor 3.YXu,RLiao,NaLi,RXiang,PSun.PhosphorylationofTip60byp38αregulatesp53-mediatedPUMAinductionandapoptosisinresponsetoDNAdamage.Oncotarget.2014Dec30;5(24):12555-72. 4.WMou,YXu,YYe,SChen,KGong,YChen,YLiu,XLi,YTian,RXiangandNaLiExpressionofSox2inbreastcancercellspromotestherecruitmentofM2macrophagetotumormicroenvironment.CancerLetters2015Mar28;358(2):115-23.*Correspondingauthor 5.WSu,SChen,NaLi*.ThepotentialroleofSOX2intheanti-apoptosispropertyofcancercells.CancerCell&Microenvironment2014;1:e253.*Correspondingauthor 6.YXu,NaLi,RXiang,PSun.Emergingrolesofthep38MAPKandPI3K/AKT/mTORpathwaysinoncogene-inducedsenescence.Trendsinbiochemicalsciences2014Jun;39(6):268-76. 7.SChen,XLi,DLu,YXu,WMou,LWang,YChen,YLiu,XLi,LYLi,LLiu,DStupack,RAReisfeld,RXiang*andNaLi*.SOX2regulatesapoptosisthroughMAP4K4-Survivinsignalingpathwayinhumanlungcancercells.Carcinogenesis2014Mar;35(3):613-23.*Correspondingauthor 8.XLi,SChen,TSun,YXu,YChen,YLiu,RXiangandNaLi*ThenegativeregulationeffectofSOX2onFOXA1geneexpressionanditsapplicationinthediagnosisofhumanbreastandlungcancers.ClinicalLaboratory2014;60(6):909-18.*Correspondingauthor 9.JYang,ZZhang,CChen,YLiu,QSi,T-HChuang,NaLi,AGomez-Cabrero,RAReisfeld,RXiangandYLuo.MicroRNA-19a-3pinhibitsbreastcancerprogressionandmetastasisbyinducingmacrophagepolarizationthroughdownregulatedexpressionofFra-1proto-oncogene.Oncogene.2014Jun5;33(23):3014-23. 10.XLi,YXu,YChen,SChen,XJia,TSun,YLiu,XLi,RXiang*andNaLi*.SOX2promotestumormetastasisbystimulatingepithelial-to-mesenchymaltransitionviaregulationofWNT/β-cateninsignalnetwork.CancerLetters2013Aug19;336(2):379-89.*correspondingauthor 11.ATjondrokoesoemo,NaLi,PHLin,ZPan,CJFerrante,NShirokova,MBrotto,NWeislederandJMa.Type1inositol(1,4,5)-trisphosphatereceptoractivatesryanodinereceptor1tomediatecalciumsparkssignalinginadultmammalianskeletalmuscle.J.Biol.Chem.2013Jan25;288(4):2103-9. 12.SChen,YXu,YChen,XLi,WMou,LWang,YLiu,RAReisfeld,RXiang,DLv*andNaLi*.SOX2generegulatesthetranscriptionalnetworkofoncogenesandaffectstumorigenesisofhumanlungcancercells.PLOSone20127(5):e36326;2012May15.*Correspondingauthor 13.DLv,SChen,XTan,NaLi,CLiu,ZLi,ZLiu,DStupack,RReisfeld,andRXiang.Fra-1PromotesChemosensitivityofBreastTumorsbyDrivingCancerStemCellsoutofDormancy.CancerResearch2012Jul15;72(14):3451-6. 14.ZZhang,JYin,CZhang,NLiang,NBai,AChang,YLiu,ZLi,XTan,NaLi,DLv,RXiang,YTian,andCLiu.Activatingtranscriptionfactor4increaseschemotherapeuticsresistanceofhumanhepatocellularcarcinoma.CancerBiology&Therapy2012April13(8),1-8. 15.XJia,XLi,YXu,SZhang,WMou,YLiu,YLiu,DLv,CHLiu,XTan,RXiang,NaLi*.SOX2promotestumorigenesisandincreasestheanti-apoptoticpropertyofhumanprostatecancercell.JournalofMolecularCellBiology2011Aug;3(4):230-8.*Correspondingauthor 16.JHu,KQin,YZhang,JGong,NaLi,DLv,RXiangandXTan.DownregulationoftranscriptionfactorOct4inducesanepithelial-to-mesenchymaltransitionviaenhancementofCa(2+)influxinbreastcancercells.BiochemBiophysResCommun.2011Aug12;411(4):786-91. 17.XShen#,NaLi#,HLi,TZhang,FWang,QLi.IncreasedprevalenceofTregulatorycellsinthetumormicroenvironmentanditscorrelationwithTNMstageofhepatocellularcarcinoma.JournalofCancerResearchandClinicalOncology2010Nov;136(11):1745-54.#Equalcontribution 18.HMNi,CJBaty,NaLi,WGao,WXDing,MLi,XChen,JMa,GKMichalopoulosandXMYin.BidRegulatesMurineHepatocyteProliferationbyControllingERCalciumHomeostasis.Hepatology2010Jul;52(1):338-48. 19.NaLi,PLin,CCai,ZPan,NWeisleder,JMa.Theamino-terminalpeptideofBaxperturbsintracellularCa2+homeostasistoenhanceapoptosisinprostatecancercells.Am.J.Physiol.-CellPhysiology2009Feb;296(2):C267-72. 20.NaLi,LZheng,PLin,DDanielpour,ZPan,JMa.OverexpressionofBaxinducesdown-regulationofstore-operatedcalciumentryinprostatecancercells.J.CellPhysiol.2008Jul;216(1):172-9. 21.CCai,PLin,KCheung,NaLi,CLevchook,ZPan,FChristopher,GLBoulianne,JKFoskett,DDanielpour,andJMa.Thepresenilin-2looppeptideperturbsintracellularCa2+homeostasisandacceleratesapoptosis.J.Biol.Chem.2006Jun;281(24):16649-55.

学术兼职

1.2015-至今天津市免疫学会会员 2.2011-至今美国肿瘤研究协会(AACR)会员 3.2010-至今中国抗癌协会会员 4.2005-2008美国生物物理学会(BiophysicsSociety)会员

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