个人简介
教育经历
1999/09-2002/07天津医科大学,医学博士
1996/09-1999/07天津医科大学,医学硕士
1991/09-1996/07天津医科大学,医学学士
工作经历
2017/12-今南开大学医学院,教授
2009/06-2010/10美国密歇根大学,访问学者
2005/12-2017/12南开大学医学院,副教授
2002/07-2005/12南开大学医学院,讲师
承担课题项目:
1.国家自然科学基金,81671179,利用斑马鱼模型研究白细胞介素7受体在髓鞘脱失和形成中的作用机制,2017/01-2020/12,主持。
2.国家自然科学基金,81301080,小胶质细胞调控Müllerglia基础上感光细胞再生的机制,2014/01-2016/12,主持。
3.国家自然科学基金,81250017,利用转基因斑马鱼研究小胶质细胞在视网膜感光细胞损伤及再生中的作用,2013/01-2013/12,主持。
4.国家科技支撑计划,2012BAI08B06,视神经炎的临床研究——斑马鱼动物模型研究(子项目),2012/01-2014/12,子项目主持。
5.天津市应用基础与前沿技术研究计划,15JCYBJC24400,利用转基因斑马鱼筛选髓鞘损伤中的关键调控基因,2015/04-2018/03,主持。
6.天津市应用基础与前沿技术研究计划,08JCYBJC07100,甲状腺相关性眼病的分子遗传学研究,2008/04-2011/03,主持。
7.教育部留学回国人员科研启动基金,2012-1707,小胶质细胞在视网膜发育和损伤再生中的调控作用,2013/01-2015/12,主持。
讲授课程
1.口腔组织病理学
2.病理学
3.病理学实验
荣誉和奖励
1.纳米氧化钛颗粒对斑马鱼胚胎和视网膜发育的作用,第十三届“挑战杯”天津市大学生课外学术科技作品竞赛特等奖,优秀指导教师,2015
2.医学与人类健康,大学素质教育优秀通选课,获奖人:李玉皓、刘文、张京玲、王德坤,中国高等教育学会大学素质教育研究分会,2014
3.第九届天津市青年教师教学基本功大赛,优秀奖,2008
研究领域
1.人类疾病斑马鱼模型构建与机制研究;
2.纳米材料的生物毒性评价及体内外成像。
近期论文
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Ya-KunDou,YangChen,Xi-WenHe,Wen-YouLi*,Yu-HaoLi*,YuKuiZhang.Synthesisofwater-dispersibleMn2+functionalizedsiliconnanoparticlesunderroomtemperatureandatmosphericpressureforfluorescenceandmagneticresonancedual-modalityimaging.AnalChem,2017;89:11286-11292.(*Correspondingauthor)
XudanLei,ShijiaoCai,YangChen,JianlinCui,YajieWang,ZongjinLi,YuhaoLi*.Downregulationofinterleukin7receptorcontributestothedemyelinationofcentralnervoussystem.Oncotarget,2017;8(17):28395-28407.
Ya-jieWang,Shi-jiaoCai,Jian-linCui,YangChen,XinTang*,Yu-haoLi*.Correlationbetweenphotoreceptorinjury-regenerationprocessandbehaviorinazebrafishmodel.NeuralRegenRes,2017;12(5):795-803.
WeiLiu,Yong-MeiWang,Yu-HaoLi,Shi-JiaoCai,Xue-BoYin*,Xi-WenHe,Yu-KuiZhang.Fluorescentimaging-guidedchemotherapy-and-photodynamicdualtherapywithnanoscaleporphyrinmetal–organicframework.Small,2017;13(17):1603459.
Ji-ChunYang,YangChen,Yu-HaoLi,andXue-BoYin*.MagneticResonanceImaging-GuidedMulti-DrugChemotherapyandPhotothermalSynergisticTherapywithpHandNIR-StimulationRelease.ACSappliedmaterials&interfaces,2017;9(27):22278-22288.
HuiZhang,Yu-HaoLi,YangChen,Man-ManWang,Xue-ShengWang,Xue-BoYin*.FluorescenceandMagneticResonanceDual-ModalityImaging-GuidedPhotothermalandPhotodynamicDual-TherapywithMagneticPorphyrin-MetalOrganicFrameworkNanocomposites.SciRep-Uk,2017;7:44153.
Hong-LiYe,Shi-JiaoCai,SiLi,Xi-WenHe,Wen-YouLi*,Yu-HaoLi*,Yu-KuiZhang.One-potmicrowavesynthesisofwater-dispersible,highfluorescencesiliconnanoparticlesandtheirimagingapplicationsinvitroandinvivo.AnalChem,2016;88:11631-11638.
YanSun,GongZhang,ZiziHe,YajieWang,JianlinCui*,YuhaoLi*.Effectsofcopperoxidenanoparticlesondevelopingzebrafishembryosandlarvae.IntJNanomed,2016;11:905-918.
Xu-DanLei,YanSun,Shi-JiaoCai,Yang-WuFang,Jian-LinCui*,Yu-HaoLi*.Roleoftumornecrosisfactor-alphainzebrafishretinalneurogenesisandmyelination.IntJOphthalmol,2016;9(6):831-837.
YangwuFang,XudanLei,XiangLi,YananChen,FeiXu,XizengFeng*,ShihuiWei*,YuhaoLi*.AnovelmodelofdemyelinationandremyelinationinaGFP-transgeniczebrafish.BiolOpen,2015;4(1):62-68.
Yan-FeiKang,Yang-WuFang,Yu-HaoLi,WenLi,Xue-BoYin*.Nucleus-stainingwithbiomolecule-mimickingnitrogen-dopedcarbondotspreparedbyafastneutralizationheatstrategy.ChemCommun(Camb).2015;51(95):16956-16959.
Yan-FeiKang,Yu-HaoLi,Yang-WuFang,YangXu,Xiao-MiWei,Xue-BoYin*.Carbonquantumdotsforzebrafishfluorescenceimaging.SciRep,2015;5:11835.
YajieWang,ZiziHe,YangwuFang,YangXu,YananChen,GuanqunWang,YongqiangYang,ZhuoYang*,YuhaoLi*.Effectoftitaniumdioxidenanoparticlesonzebrafishembryosanddevelopingretina.IntJOphthalmol,2014;7(6):917-923.
Qian-QianShi‡,YuhaoLi‡,YangXu,YueWang,Xue-BoYin*,Xi-WenHeandYu-KuiZhang.High-yieldandhigh-solubilitynitrogen-dopedcarbondots:formation,fluorescencemechanismandimagingapplication.RSCAdvances,2014;4:1563-1566.(‡Equalcontribution)
YikeYuan,YaguangZhang,ShaohuaYao*,HuashanShi,XiHuang,YuhaoLi,YuquanWei,ShuoLin.ThetranslationinitiationfactorEif3iupregulatesvascularendothelialgrowthfactorA,acceleratescellproliferation,andpromotesangiogenesisinembryonicdevelopmentandtumorigenesis.JBiolChem,2014;289(41):28310-28123.
YangXu,Yu-HaoLi,YueWang,Jian-LinCui,Xue-BoYin*,Xi-WenHe,Yu-KuiZhang.13C-engineeredcarbonquantumdotsforinvivomagneticresonanceandfluorescencedual-response.Analyst,2014;139(20):5134-5139.
Xiao-MiWei,YangXu,Yu-HaoLi,Xue-BoYin*,Xi-WenHe.Ultrafastsynthesisofnitrogen-dopedcarbondotsvianeutralizationheatforbioimagingandsensingapplications.RSCAdv,2014;4:44504-44508.
YangXi,DongyanChen,LeiSun,YuhaoLi*,LeiLi*.Characterizationofzebrafishmutantswithdefectsinbonecalcificationduringdevelopment.BiochemBiophysResCommun,2013;440:132-136.
TaoHuang,JianlinCui,LeiLi,PeterF.Hitchcock,YuhaoLi*.Theroleofmicrogliaintheneurogenesisofzebrafishretina.BiochemBiophysResCommun,2012;421:214-220.
学术兼职
1.国家自然科学基金委,基金项目同行评议专家
2.天津市免疫学会,会员