向荣 - 南开大学

个人简介

教育背景 1989.07-1992.07上海交通大学医学院（原上海第二医科大学）细胞生物学与实验核医学系，获医学科学博士学位 1986.07-1989.07重庆医科大学临床生物化学专业，获医学硕士学位 1978.02-1982.02重庆医科大学，获医学学士学位工作经历 2007.3-2019.7南开大学医学院，院长，博士生导师 2007.3-2008.12美国Scripps研究所免疫系，副教授(AssociateProfessor) 2001.5-2007.3美国Scripps研究所免疫系，助理教授(AssistantProfessor) 1999.5-2001.5美国Scripps研究所免疫系，资深博士后(SeniorPostdoc) 1996.5-1999.5美国Scripps研究所免疫系，博士后(Postdoc) 1992.7-1996.5复旦大学上海医学院（原上海医科大学），助教，副教授主持主要科研项目对发展中国家科技援助项目“中泰生物疫苗转化医学中心”，起止年月：2015.12-2018.11，项目负责人；国家重大科学研究计划（973计划）“肿瘤干细胞在实体肿瘤发展中的调控机制研究”，起止年月：2013.01-2017.12，首席科学家；国家国际科技合作专项“新型乳腺癌早期预警系统的建立及防治方法的合作研究”，起止年月：2012.06-2015.05，项目负责人。

研究领域

（1）肿瘤微环境与肿瘤干细胞之间相互调控的分子机制及肿瘤转移和复发过程研究；（2）肿瘤特异性抑制小分子药物的研发及靶向药物载体的研究；（3）新型肿瘤蛋白疫苗和DNA疫苗及抗肿瘤融合蛋白的研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.ZhangZ.,YinJ.,YangJ.,ShenW.,ZhangC.,MouW.,LuoJ.,YanH.,SunP.,LuoY.,TianY.,XiangR.miR-885-5psuppresseshepatocellularcarcinomametastasisandinhibitsWnt/β-cateninsignalingpathway.Oncotarget.2016Oct12.doi:10.18632/oncotarget.12602. 2.Zhao,Shuangtao;Dong,Xiaoli;Shen,Wenzhi;Ye,Zhen;Xiang,Rong;Machinelearning-basedclassificationofdiffuselargeB-celllymphomapatientsbyeightgeneexpressionprofiles.CancerMedicine,2016May,5(5):837-52. 3.YeZhen,GuoChunlei,ShenWenzhi,ZhaoShuangtao,LuoNa,WangRongrong,LuoXiaohe,NiuHaiying,LuoDehong,JiangShan,TanXiaoyue,XiangRong.Clinicopathologicsignificanceoflegumainoverexpressionincancer:asystematicreviewandmeta-analysis.ScientificReports,2015Nov26,5(16599). 4.ChangA,ChenY,ShenW,GaoR,ZhouW,YangS,LiuY,LuoY,ChuangTH,SunP,LiuC,XiangR.Ifit1ProtectsAgainstLipopolysaccharideandD-galactosamine-InducedFatalHepatitisbyInhibitingActivationoftheJNKPathway.JournalofInfectiousDiseases.2015Nov1,212(9):1509-1520. 5.Xu,Y.,Zhang,S.,Niu,H.,Ye,Y.,Hu,F.,Chen,S.,Li,X.,Luo,X.,Jiang,S.,Liu,Y.,Chen,Y.,Li,J.,Xiang,R.&Li,N.STIM1acceleratescellsenescenceinaremodeledmicroenvironmentbutenhancestheepithelial-to-mesenchymaltransitioninprostatecancer.ScientificReports,2015Aug10,5(11754). 6.ZeLiu,MinXiong,JunboGong,YanZhang,NanBai,YunpingLuo,LuyuanLi,YuquanWei,YanhuaLiu,XiaoyueTan&RongXiang.Legumainprotease-activatedTAT-liposomecargofortargetingtumorsandtheirmicroenvironment.NatureCommunications,2014Jun27,5:4280. 7.ChenS,LiX,LuD,XuY,MouW,WangL,ChenY,LiuY,LiX,LiLY,LiuL,StupackD,ReisfeldRA,XiangR&LiN.SOX2regulatesapoptosisthroughMAP4K4-Survivinsignalingpathwayinhumanlungcancercells.Carcinogenesis.2014Mar;35(3):613-23. 8.LiX,XuY,ChenY,ChenS,JiaX,SunT,LiuY,LiX,XiangR,LiN.SOX2promotestumormetastasisbystimulatingepithelial-to-mesenchymaltransitionviaregulationofWNT/β-cateninsignalnetwork.CancerLetters.2013Aug19;336(2):379-89. 9.BaiN,ZhangC,LiangN,ZhangZ,ChangA,YinJ,LiZ,LuoN,TanX,LuoN,LuoY,XiangR,LiX,ReisfeldRA,StupackD,LvD,LiuC.Yes-associatedprotein(YAP)increaseschemosensitivityofhepatocellularcarcinomacellsbymodulationofp53.CancerBiology&Therapy.2013Jun;14(6):511-20. 10.LiuZ,LvD,LiuS,GongJ,WangD,XiongM,ChenX,XiangR,TanX.Alginicacid-coatedchitosannanoparticlesloadedwithlegumainDNAvaccine:effectagainstbreastcancerinmice.PLoSOne.2013;8(4):e60190. 11.ZhangC,BaiN,ChangA,ZhangZ,YinJ,ShenW,TianY,XiangR,LiuC.ATF4isdirectlyrecruitedbyTLR4signalingandpositivelyregulatesTLR4-triggedcytokineproductioninhumanmonocytes.Cellular&MolecularImmunology.2013Jan;10(1):84-94. 12.SuW,WangL,ZhouM,LiuZ,HuS,TongL,LiuY,FanY,KongD,ZhengY,HanZ,WuJC,XiangR,LiZ.Humanembryonicstemcell-derivedendothelialcellsascellulardeliveryvehiclesfortreatmentofmetastaticbreastcancer.CellTransplantation.2013;22(11):2079-90. 13.ManqianZhou,LinaWang,WeijunSu,LinglingTong,YanhuaLiu,FanYan,YizhouZheng,HuiZhao,RongXiang,ZongjinLi.Assessmentoftherapeuticefficacyofliposomemediatedgenedeliverybymolecularimagingforcancertherapy.JournalofBiomedicalNanotechnology.2012Oct;8(5):742-50. 14.SiChen;YingxiXu;YananChen;XuefeiLi;WenjunMou;LinaWang;YanhuaLiu;RalphA.Reisfeld;RongXiang;DanLv;NaLi.SOX2generegulatesthetranscriptionalnetworkofoncogenesandinhibitstumorigenesisofhumanlungcancercells.PLoSOne.2012;7(5):e36326. 15.LinaWang,SiChen,MingnaZhang,NaLi,YananChen,WeijunSu,YanhuaLiu,DanLu,SanglinLi,YixuanYang,ZongjinLi,PengpengQu,HuaidongHu,RongXiang.Legumain:aBiomarkerfortheDiagnosisandPrognosisofHumanOvarianCancer.JournalofCellularBiochemistry.2012Aug;113(8):2679-86. 16.LuD,ChenS,TanX,LiN,LiuC,LiZ,LiuZ,StupackDG,ReisfeldRA,XiangR,Fra-1promotesbreastcancerchemosensitivitybydrivingcancerstemcellsfromdormancy.CancerResearch.2012Jul15;72(14):3451-6. 17.LinaWang,WeijunSu,ZeLiu,ManqianZhou,SiChen,YananChen,DanLu,YanhuaLiu,FanYan,JoesphC.Wu,RongXiang,ZongjinLi.CD44AntibodyTargetedLiposomeforMolecularImagingandTherapyofHepatocellularCarcinoma.Biomaterials.2012Jul;33(20):5107-14. 18.JiajiaHu,KunhuaQin,YanZhang,JunboGong,NaLi,DanLv,RongXiangandXiaoyueTan.DownregulationoftranscriptionfactorOct4inducesanepithelial-to-mesenchymaltransitionviaenhancementofCa(2+)influxinbreastcancercells.Biochemical&BiophysicalResearchCommunications.2011Aug12;411(4):786-91. 19.XianpeiJia,XuefeiLi,YingxiXu,ShuZhang,WenjunMou,YanhuaLiu,YinLiu,DanLv,Cheng-HuLiu,XiaoyueTan,RongXiangandNaLi.SOX2promotestumorigenesisandincreasestheanti-apoptoticpropertyofhumanprostatecancercell.JournalofMolecularCellBiology.2011Aug;3(4):230-8. 20.XiangR,LiaoD,ChengT,ZhouH,ShiQ,ChuangTS,MarkowitzD,ReisfeldRA,LuoY.DownregulationoftranscriptionfactorSOX2incancerstemcellssuppressesgrowthandmetastasisoflungcancer.BritishJournalofCancer.2011Apr26;104(9):1410-7. 21.SuW,ZhouM,ZhengY,FanY,WangL,HanZ,KongD,ZhaoRC,WuJC,XiangR,LiZ.Bioluminescencereportergeneimagingcharacterizehumanembryonicstemcell-derivedteratomaformation.JournalofCellularBiochemistry2011Mar;112(3):840–848.