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研究领域

主要从事药物设计和开发,生物药物设计应用研究。

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Wang Z, Iwasaki M, Ficara F, Lin C, Matheny C, Wong SH, Smith KS, Cleary ML. GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell 2010 June 15; 17(6):597-608 Comment in: Nat Rev Cancer. 2010 Aug; 10(8):529. Cancer Cell. 2010 Jun 15;17(6):529-31 Wang Z, Smith KS, Murphy M, Piloto O, Somervaille TC, Cleary ML. Glycogen synthase kinase-3 in MLL leukemia maintenance and targeted therapy. Nature 2008 Oct 30; 455(7217):1205-1209. Comment in: Cancer Cell. 2008 Nov 4;14(5):351-3. Espinosa I, Lee CH, Kim MK, Rouse BT, Subramanian S, Montgomery K, Varma S, Corless CL, Heinrich MC, Smith KS, Wang Z, Rubin B, Nielsen TO, Seitz RS, Ross DT, West RB, Cleary ML, van de Rijn MA novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol. 2008 32(2):210-8. Wilson WA, Wang Z, Roach PJ. Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p. Biochem Biophys Res Commun. 2005 Apr 1;329(1):161-7. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004. Jul;24(13):5639-49. Wilson WA, Wang Z, Roach PJ. Systematic Identifcation of the Genes Affecting Glycogen Storage in the Yeast Saccharomyces cerevisiae: Implication of the Vacuolar H+-ATPase. Molecular and Cellular Proteomics 2002.1(3): 232-242 Wilson WA, Wang Z, Roach PJ. Analysis of respiratory mutants reveals new aspect of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p. FEBS letters 2002. 515(1-3): 104-108 Wang Z, Wilson WA, Fujino M, Roach PJ. Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of the AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p. Mol. Cell. Biol. 2001. 21(17): 5742-5752 Wang Z, Wilson WA, Fujino M, Roach PJ. The Yeast Cyclins Pcl6p and Pcl7p are involved in the Control of Glycogen Storage by the Cyclin -Dependent Protein Kinase Pho85p. FEBS letters 2001. 506(3): 277-80 Jiang Y, Wang Z, Liu L, Shi Y. Screening For Mut+ and Mut s Transformants of Pichia with PCR Analysis. ACTA LASER BIOLOGY SINCA 1998. 7(3): 189-191

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