研究领域
主要研究领域为自身免疫性疾病,肿瘤的病理机制,以及针对这些难治性疾病的免疫治疗、生物治疗和创新药物的研发。
近期论文
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1. Li Q and McDevitt HO. The role of interferon alpha in initiation of type I diabetes in the NOD mouse. Clinical Immunol. 2011 Jul, 140(1):3-7
2. Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W, Perl A. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol. 2009 Feb 15;182(4):2063-73.
3. Li Q, Xu BH, Michie SA, Rubins KH, Schreiber RD and McDevitt HO. IFN-a initiates Type 1 diabetes in Non-obese Diabetic Mouse. Proc Natl Acad Sci USA. 2008 Aug 26; 105(34): 12439-44.
4. Chan BC, Ching AK, To KF, Leung JC, Chen S, Li Q, Lai PB, Tang NL, Shaw PC, Chan JY, James AE, Lai KN, Lim PL, Lee KK, Chui YL. BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma. Oncogene. 2008 Feb 21;27(9):1208-17.
5. Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL. BRE enhances in vivo growth of tumor cells. Biochem Biophys Res Commun. 2005 Jan 14;326(2):268-73.
6. Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL. A Death Receptor-Associated Antiapoptotic Protein, BRE, Inhibits Mitochondrial Apoptotic Pathway. J Biol Chem. 2004 Dec 10;279(50):52106-16.
7. Ching AK, Li Q, Lim PL, Chan JY, Chui YL. Expression of a conserved mouse stress-modulating gene, Bre: comparison with the human ortholog. DNA Cell Biol. 2003 Aug; 22(8):497-504.
8. Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL. Expression of human BRE in multiple isoforms. Biochem Biophys Res Commun. 2001 Nov 2; 288(3):535-45.