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研究领域

主要从事肿瘤免疫相关基础研究,在基因调控与遗传改造及基因敲除等技术方面有丰富的工作经验。

近期论文

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1. Wang H, Wang HS, Zhou BH, Li CL, Zhang F, Wang XF, Zhang G, Bu XZ, Cai SH, Du J. Epithelial-Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer. PLoS One. 2013;8(2):e56664. doi: 10.1371/journal.pone.0056664.(通信作者) 2. Fang R, Zhang G, Guo Q, Ning F, Wang H, Cai S, Du J. Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma. Cancer Lett. 2013;22(1). doi:pii: S0304-3835(13)00043-8. 10.1016/j.canlet.2013.01.014. (通信作者) 3. Jiang GM, Wang HS,Zhang F, Zhang KS, Liu ZC, Fang Rui, Wang H, Cai SH, Du J. Histone deacetylase inhibitors induction of epithelial-mesenchymal transitions via up-regulation of Snail facilitates cancer progression. Biochimica et Biophysica Acta - Molecular Cell Research. 2012. doi: 10.1016/j.bbamcr.2012.12.002. (通信作者) 4. Liu H, Zhou BH, Qiu X, Wang HS, Zhang F, Fang R, Wang XF, Cai SH, Du J, Bu XZ. T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells. Free Radical Biology & Medicine. 2012;DOI j.freeradbiomed.2012.10.537.(通信作者) 5. Wang HS, Chen ZJ, Zhang G, Ou XL, Yang XL, Wong CK, Giesy JP, Du J, Chen SY, A Novel Micro-Linear Vector for In Vitro and In Vivo Gene Delivery and Its Application for EBV Positive Tumors. PLoS One. 2012;7(10):e47159. doi: 10.1371/journal.pone.0047159.(通信作者) 6. Zhang P, Jiang GM, Gao J, Li LL, Du J and Jiao XY. SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK/STAT1 signaling pathway in gallbladder carcinoma cells. Oncology Reports. 2013, 29: 269-275. doi: 10.3892/or.2012.2073.(通信作者) 7. Wang HS, Sthiannopkao S, Du J, Chen ZJ, Kim KW, Yasin MS M, Hashim JH, Wong ChK C, Wong MH. Daily intake and human risk assessment of organochlorine pesticides (OCPs) based on C ambodian market basket data. Journal of Hazardous Materials. 2011, 192: 1441-1449. doi: 10.1016/j.jhazmat.2011.06.062.(第三作者) 8. 由振源,陈丹扬,刘楚琪,袁慧敏,王红胜,杜军. 利用TNF-α诱导建立结肠癌细胞HCT116体外侵袭模型. 中国细胞生物学学报 2012, 34(10): 1004–1009. (通信作者) 9. 严力韬, 张帆,王昊,权美玉,杜军. 抗Nodal单克隆抗体的制备及夹心ELISA试剂盒的研制. 重庆理工大学学报(自然科学). 2012,26(9)31-34. (通信作者) 10. 方瑞, 郭强, 严力韬, 杜军. Nodal信号调控及在肿瘤治疗中的应用价值. 中华肿瘤防治杂志. 2012,19:872-876. (通信作者) 11. Wang HS, Chen ZJ, Ho KL, Ge LC, Du J, Lam MH, Giesy JP, Wong MH, Wong CK Hydroxylated and methoxylated polybrominated diphenyl ethers in blood plasma of humans in Hong Kong. Environment International. 2012, 47:66-72. doi: 10.1016/j.envint.2012.06.004. 12. Yang XL, Rutnam ZJ, Jiao Cw, Wei D, Xie YZ, Du J, *Zhong L, Yang BB. An anti-let-7 sponge decoys and decays endogenous let-7 functions. Cell Cycle. 2012, 16(11):3097–3108. DOI:10.4161/cc.21503. 13. Qiao RR, Zeng JF, Jia QJ, Du J, Shen L, *Gao MY. Magnetic Iron Oxide Nanoparticle-an Important Cornerstone of MR Molecular Imaging of Tumors. Acta Physico-Chimica Sinica. 2012, 5(28):993–1011. DOI:10.3866/PKU.WHXB201203023 14. Zuo YL, Yu Y, Wang S, Shao WY, Zhou BH, Lin L, Luo ZY, Huang RG, Du J. *Bu XZ. Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNF alpha-induced nuclear factor-kappa B activation inhibition. European Journal of Medicinal Chemistry. 2012, 50:393–404. DOI:10.1016/j.ejmech.2012.02.023. 15. 张欢, 方瑞, 黄思超, 杨倩之, 杜军, 蔡绍晖. 稳定表达重组小鼠FAPα蛋白细胞株的构建. 生物技术通报. 2012,5:93-98 16. 马伟峰, 杨飞华, 赵海山, 杜军, 蔡绍晖. FAPα酶激活式靶向抗肿瘤前药:Z-GP-Dox对斑马鱼的毒性评价. 中国生物工程杂志. 2012, 07:37-42 17. 乔瑞瑞, 曾剑峰, 贾巧娟, 杜军, 沈琳, 高明远. 磁性氧化铁纳米颗粒——通向肿瘤磁共振分子影像的重要基石. 物理化学学报. 2012, 05:993-1011 18. Wang HS, Du J, Ho K, Leung HM, Lam MHW, Giesy JP, Wong CKC, Wong MH. Exposure of Hong Kong Residents to PBDEs and Their Structure Analogues through Market Fish Consumption. Journal of Hazardous Materials. 2011, 192:374-380. DOI: dx.doi.org/10.1016/j.jhazmat.2011.05.036.(第二作者) 19. Wang HS, Du J, Leung H, Leung AOW, Liang P, Giesy JP, Wong CKC, Wong MH. Distribution and Source Apportionments of Polychlorinated Biphenyls (PCBs) in Mariculture Sediments from the Pearl River Delta, South China. Marine Pollution Bulletin. 2011, 63:516-522. DOI: 10.1016/j.marpolbul.2011.02.009.(第二作者) 20. Yi YM, Zhang G, Zeng J, Huang SC, Li LL, Fang R, Jiang GM, Bu XZ, Cai SH, and Du J. FAPτ-MT elicits effective antitumor response by targeting indolamine-2,3-dioxygenase in antigen presenting cells. Cancer Biology & Therapy. 2011, 11(10) 1-8.(通信作者)

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