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个人简介

教育经历 2014/11-2015/11英国诺丁汉大学,访问学者 2008/05-2008/08美国Huahai US Co., Ltd.,Senior Research Fellow 2003/09-2006/06四川大学,获得药剂学博士学位; 1995/09-1998/06华西医科大学(现四川大学),获得药剂学硕士学位 1991/09-1995/06华西医科大学(现四川大学),获得药学学士学位 工作经历 2017/1至今中山大学药学院教授 2016/4-2017/4滇西应用技术大学傣医药学院副院长(挂职) 2010/1-2017/1中山大学药学院副教授 1998/7-2010/1中山大学药学院(系)助教、讲师

研究领域

菌膜靶向递药系统;肿瘤靶向递药系统;生物大分子口服给药

近期论文

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LI Xuewen, HUANG Meixiang, LO Kakei, CHEN Wei-Li, HE Yingyan He, XU Yongli, ZHENG Huizhen, HU Haiyan*(共同通讯), WANG Jun * . Anti-Diabetic E↵ect of a Shihunine-Rich Extract of Dendrobium loddigesii on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK–GLUT4–PPARα.Molecules, 2019, 24, 2673.IF: 3.098 CHEN Xiaonan, LI Pengyu, SHEN Yuanna, Zou Yiqing, YUAN Gang*, HU Haiyan*(共同通讯). Rhamnolipid-involved antibiotics combinations improve the eradication of Helicobacter pylori biofilm in vitro: A comparison with conventional triple therapy. Microbial Pathogenesis, 2019, 131, 112-119 SHEN Yuanna, LI Pengyu, CHEN Xiaonan, Zou Yiqing, LI Huatian, YUAN Gang, HU Haiyan* (通讯作者). Activity of Sodium Lauryl Sulfate, Rhamnolipids, and N-Acetylcysteine Against Biofilms of Five Common Pathogens. Microbial Drug Resistance, 2019, https://doi.org/ 10.1089/mdr.2018.0385 LI Pengyu, CHEN Xiaonan, SHEN Yuanna, ZOU Yiqing, YUAN Gang, HU Ping, HU Haiyan*(通讯作者). Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. JControl Release, 2019, 300: 52-63. IF: 7.877 SONG Jia, LIN Chuchu, YANG Xuan, XIE Yanqi, HU Ping, LI Huatian, ZHU Wenbo, HU Haiyan*(通讯作者). Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways. JControl Release, 2019, 294:27-42 IF: 7.877 WANG Yalong, HUANG Huizhi, ZOU Haijuan, TIAN Xuyan, HU Jun, QIU Pengxin, HU Haiyan*(通讯作者), YAN Guangmei. Liposome Encapsulation of Oncolytic Virus M1 To Reduce Immunogenicity and Immune Clearance in Vivo. Mol Pharm, 2019, 16(2):779-785 IF: 4.556 LI Xuewen, CHEN Huiping, HE Yingyan, CHEN Weili, CHEN Jianwen, GAO Lu, HU Haiyan*(共同通讯),WANG Jun*. Effects of Rich-Polyphenols Extract of Dendrobium loddigesii on Anti-Diabetic, Anti-Inflammatory, Anti-Oxidant, and Gut Microbiota Modulation in db/db Mice. Molecules, 2018, 23(12), 3245 IF:3.098 CHENHuiping, LIXuewen, XUYongli, LOKakei, ZHENGHuizhen, HUHaiyan *(共同通讯), WANGJun*, LINYongcheng. Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay. Molecules, 2018, 23(5), 1185 IF:3.098 ZHOU Huanbin, CHEN Jiashu, LI Shunyi, ZHANG Jianpan, ZHU Chun’e, RAN Hao, LUO Meihua, PAN Xin*, HU Haiyan*(共同通讯), WU Chuanbin. Preparation of Acid‐Resistant Microcapsules with Shell‐Matrix Structure to Enhance Stability of Streptococcus Thermophilus IFFI 6038. J Food Sci, 2017, 82(8):1978-1984 GUO Qin, CAI Jie, LI Pengyu, XU Dongling, NI Xiaomin, WEN Hui, LIU Dan, LIN Suizhen , HU Haiyan*(通讯作者). Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design, Dev &Therapy, 2016, 10: 3789-3798 TUO Jue, XIE Yanqi, SONG Jia, CHEN Yizhen, GUO Qin, LIU Xin, NI Xiaomin, XU Dongling, HUANAG Huizhi, YIN Sheng, ZHU Wenbo, WU Jun, HU Haiyan*(通讯作者). Development of a novel berberine-mediated mitochondria-targeting nano-platform for drug-resistant cancer therapy. JMaterial Chem B, 2016, 4: 6856-64 IF: 4.872 LI Pengyu, SONG Jia, NI Xiaomin, GUO Qin, WEN Hui, Qiuyun Zhou, SHEN Yuanna, HUANG Yijun, QIU Pengxin, LIN Suizhen, HU Haiyan*(通讯作者). Comparison in toxicity and solubilizing capacity of hydroxypropyl-β-cyclodextrin with different degree of substitution. Int J Pharmaceut, 2016,513: 347–356 IF:3.994 XING Qiao, Song Jia, YOU Xiuhua, XU Dongling, WANG Kexin, SONG Jiaqi, GUO Qin, LI Pengyu Li, WU Chuanbin, HU Haiyan*(通讯作者). Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously. Int J Pharmaceut,2016, 511: 709–718 IF:3.994 WANG Youqiong, TANG Lipeng, YIN Wei, CHEN Jiesi, LENG Tiandong, ZHENG Xiaoke, ZHU Wenbo, ZHANG Haipeng, QIU Pengxin, YANG Xiaoxiao, YAN Guangmei, HU Haiyan*(通讯作者). Simultaneous Determination of Seven Neuroactive Steroids Associated with Depression in Rat Plasma and Brain by High Performance Liquid Chromatography–Tandem Mass Spectrometry. Anal Sci,2016, 32(9):981-8 CAI Jie, HUANG huizhi, SONG Weijuan, HU Haiyan*(通讯作者), CHEN Jiesi, ZHANG Liyan, LI Pengyu, WU Rui, WU Chuanbin. Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro. Int J Pharmaceut, 2015, 495 (2): 728-737 IF: 3.994 CHEN Yizhen, TUO Jue, HUANG Huizhi, LIU Dan, YOU Xiuhua, MAI Jialuo, SONG Jiaqi, XIE Yanqi, WU Chuanbin and HU Haiyan*(通讯作者). Optimized mixed oils remarkably reduce the amount of surfactants in microemulsions without affecting oral bioavailability of ibuprofen by simultaneously enlarging microemulsion areas and enhancing drug solubility. Int J Pharmaceut, 2015, 487(1-2):17-24 IF: 3.994 TANG Lipeng, WANG Youqiong, LENG Tiandong, SUN Huanhuan, ZHOU Yuehan, ZHU Wenbo, QIU Pengxin, ZHANG Jingxia, LU Bingzheng, YAN Min, CHEN Wenli, SU Xinwen, YIN Wei, HUANG Yijun, HU Haiyan* (共同通讯), YAN Guangmei*. Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels. Steroids, 2015, 98:166-72 WANG Yalong, JIANG Han, HUANG Huizhi, XIE Yanqi, ZHAO Yunsi, YOU Xiuhua, TANG Lipeng, WANG Youqiong, YIN Wei, QIU Pengxin, YAN Guangmei and HU Haiyan*(通讯作者). Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. JSep Sci, 2015, 38(5): 796-803 FU Shengnan, XIE, Yanqi, TUO Jue, WANG Yalong, ZHU Wenbo, WU Sihan, YAN Guangmei, HU Haiyan*(通讯作者). Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells MEDCHEMCOMM, 2015. 6(1), 164-173 HUANG Meihong, SONG Jiaqi,LU Bingzheng, HUANG Huizhi, CHENG Yizhen, YIN Wei, ZHU Wenbo, SU Xinwen, WU Chuanbin, HU Haiyan*(通讯作者). Synthesis of taurine–fluorescein conjugate and evaluation of its retina-targeted efficiency in vitro. Acta Pharmaceutica Sinica B, 2014, 4, 447-453 IF:5.970

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