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研究领域

主要从事药物固体形态的研究,运用超分子化学原理和晶体工程技术研究药物的固体形态,以达到改善药物水溶性、渗透性、稳定性、生物利用度等性质的目的。

近期论文

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1. Yan Yan,Jia-Mei Chen(*),Tong-Bu Lu,Thermodynamics and Preliminary Pharmaceutical Characterization of Melatonin–Pimelic Acid Cocrystal Prepared by a Melt Crystallization Method,CrystEngComm,2015,17(3):612-620。 2. Jia-Mei Chen,Song Li,Tong-Bu Lu(*),Pharmaceutical Cocrystals of Ribavirin with Reduced Release Rates,Crystal Growth & Design,2014,14(12):6399-6408。 3. Jia Yao,Jia-Mei Chen(*),Yi-Bo Xu,Tong-Bu Lu(*),Enhancing the Solubility of 6-Mercaptopurine by Formation of Ionic Cocrystal with Zinc Trifluoromethanesulfonate: Single-Crystal-to-Single-Crystal Transformation,Crystal Growth & Design,2014,14(10):5019-5025。 4. Song Li,Jia-Mei Chen(*),Tong-Bu Lu(*),Synthon Polymorphs of 1 : 1 Co-crystal of 5-Fuorouracil and 4-Hydroxybenzoic Acid: Their Relative Stability and Solvent Polarity Dependence of Grinding Outcomes,CrystEngComm,2014,16(28):6450-6458。 5. Jia-Xi Song,Yan Yan,Jia Yao,Jia-Mei Chen(*),Tong-Bu Lu(*),Improving the Solubility of Lenalidomide via Cocrystals,Crystal Growth & Design,2014,14(6):3069-3077。 6. Jia Yao,Yong-Hui Mo,Jia-Mei Chen(*),Tong-Bu Lu(*),New Approach to Reduce the Overhigh Plasma Concentration of Captopril by the Formation of Zinc Coordination Polymer,Crystal Growth & Design,2014,14(5):2599-2604。 7. Wen-Juan Ma,Jia-Mei Chen,Long Jiang,Jia Yao,Tong-Bu Lu(*),The Delivery of Triamterene by Cucurbit[7]uril: Synthesis, Structures and Pharmacokinetics Study,Molecular Pharmaceutics,2013,10(12):4698-4705。 8. Qian Tao,Jia-Mei Chen(*),Tong-Bu Lu,Two Polymorphs and One Hydrate of a Molecular Salt Involving Phenazopyridine and Salicylic Acid,CrystEngComm,2013,15(39):7852-7855。 9. Yan Yan,Jia-Mei Chen(*),Tong-Bu Lu(*),Simultaneously Enhancing the Solubility and Permeability of Acyclovir by Crystal Engineering Approach,CrystEngComm,2013,15(33):6457-6460。 10. Na Geng,Jia-Mei Chen(*),Zi-Jian Li,Long Jiang,Tong-Bu Lu(*),Approach of Cocrystallization to Improve the Solubility and Photostability of Tranilast,Crystal Growth & Design,2013,13(8):3546-3553。 11. Jia-Mei Chen,Tong-Bu Lu(*),New Crystalline Forms of Mebendazole with n-Alkyl Carboxylic Acids: Neutral and Ionic Status,Chinese Journal of Chemistry,2013,31(5):635-640。 12. Lin-Lin Xu,Jia-Mei Chen(*),Yan Yan,Tong-Bu Lu(*),Improving the Solubility of 6-Mercaptopurine via Cocrystals and Salts,Crystal Growth & Design,2012,12(12):6004-6011。 13. Zi-Zhou Wang,Jia-Mei Chen(*),Tong-Bu Lu(*),Enhancing the Hygroscopic Stability of S-Oxiracetam via Pharmaceutical Cocrystals,Crystal Growth & Design,2012,12(9):4562-4566。 14. Jia-Mei Chen,Zi-Zhou Wang,Chuan-Bin Wu,Song Li,Tong-Bu Lu(*),Crystal Engineering Approach to Improve the Solubility of Mebendazole,CrystEngComm,2012,14(19):6221-6229。 15. Qian Tao,Jia-Mei Chen(*),Lei Ma,Tong-Bu Lu(*),Phenazopyridine Cocrystal and Salts That Exhibit Enhanced Solubility and Stability,Crystal Growth & Design,2012,12(6):3144-3152。 16. Bing-Xin Zhao,Ying Wang(*),Dong-Mei Zhang,Xiao-Jun Huang,Liang-Liang Bai,Yan Yan,Jia-Mei Chen,Tong-Bu Lu,Yi-Tao Wang,Qing-Wen Zhang(*),Wen-Cai Ye(*),Virosaines A and B, Two New Birdcage-Shaped Securinega Alkaloids with an Unprecedented Skeleton from Flueggea virosa,Organic Letters,2012,14(12):3096-3099。 17. Yan Yan,Jia-Mei Chen(*),Na Geng,,Tong-Bu Lu(*),Improving the Solubility of Agomelatine via Cocrystals,Crystal Growth & Design,2012,12(5):2226-2233。 18. Jia-Mei Chen,Chuan-Bin Wu,Tong-Bu Lu(*),Application of Supramolecular Chemistry on Pharmaceutical Cocrystals,Chemical Journal of Chinese Universities,2011,32(9):1996-2009。 19. Sai-Li Zheng,Jia-Mei Chen(*),Wei-Xiong Zhang,Tong-Bu Lu(*),Structures of Polymorphic Agomelatine and Its Cocrystals with Acetic Acid and Ethylene Glycol,Crystal Growth & Design,2011,11(2):466-471。

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