研究领域
1. 遗传药理学
2. 药物代谢与药动学
3. 药物相互作用
近期论文
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1. Li JL, Wang XD, Chen SY, Liu LS, Fu Q, Chen X, Teng LC, Wang CX, Huang M. Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective. Pharmacogenomics J. 2010 Jun 1. doi:10.1038/tpj.2010.42.
2. Li JL, Wang XD, Wang CX, Fu Q, Liu LS, Huang M, Zhou SF. Rapid and simultaneous determination of tacrolimus (FK506) and diltiazem in human whole blood by liquid chromatography-tandem mass spectrometry: application to a clinical drug-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):111-118.
3. Wang XD, Li JL[共同第一作者], Su QB, Deng XY, Lu Y, Chen J, Zhang JX, Zhao LZ, Zuo Z, Chan E, Chen X, Chowbay B, Xue CC, Huang M, Zhou SF. A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese. Curr Drug Metab. 2007 Dec;8(8):778-786.
4. Wang XD, Li JL, Su QB, Guan S, Chen J, Du J, He YW, Zeng J, Zhang JX, Chen X, Huang M, Zhou SF. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. Brit J Clin Pharmacol. 2009 Feb;67(2):255-261.
5. Wang XD, Li JL, Lu Y, Chen X, Huang M, Chowbay B, Zhou SF.Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):534-544.
6. Wang YX, Wang CX, Li JL, Wang XD, Zhu GL, Chen X, Bi HC, Huang M. Effect of genetic polymorphisms of CYP3A5 and MDR1 on Cyclosporine concentration during the early stage after renal transplantation in Chinese Patients co-treated with diltiazem. Eur J Clin Pharmacol. 2009 Mar;65(3):239-247.
7. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu LJ, Wang YT, Huang M. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm. 2010;389(1-2):114-121.
8. Wang XD, Deng XY, Chen J, Li JL, Chen X, Zhao LZ, Lu Y, Chowbay B, Su QB, Huang M, Zhou SF. Single nucleotide polymorphisms of the pregnane X receptor gene in Han Chinese and a comparison with other ethnic populations. Pharmacology. 2008;81(4):350-354.
9. Qin XL, Bi HC, Wang CX, Li JL, Wang XD, Liu LS, Chen X, Huang M. Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr. 2010;24(4):399-405.
10. Cen HJ, Zeng WT, Leng XY, Huang M, Chen X, Li JL, Huang ZY, Bi HC, Wang XD, Zhou RN, Zheng QS, Zhao LZ. CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement. Brit J Clin Pharmacol. In press
11. 李嘉丽, 王雪丁, 王长希, 黄民. 合并使用地尔硫卓或五酯片对肾移植患者他克莫司药动学的影响的比较. 2008, 第十一次全国临床药理学学术大会, 会议论文. 优秀论文一等奖
12. 李嘉丽, 王长希, 黄民. CYP3A5、MDR1基因多态性对地尔硫卓与他克莫司相互作用影响的研究. 2009, 广东省药理学会第六次会员大会, 会议论文. 优秀论文三等奖
13. 李嘉丽, 黄民.CYP3A5、MDR1基因多态性与他克莫司在肾移植病人体内血药浓度的相关性研究. 2007, 广东省药理学会2007学术年会，会议论文.
14. 赖泳，李嘉丽，王雪丁，董寿堂，李辉，黄民. 多药抗药基因1C3435T在中国佤族、白族和藏族人群中的基因多态性. 中国药理学与毒理学杂志.2009,23(3):208-213.
15. 王一西，李嘉丽，邓小莹，黄民. 基因多态性对器官移植中免疫抑制剂疗效影响的研究进展. 中国临床药理学杂志.2008,24(1):78-82.
16. 王雪丁，李嘉丽，郭颖，邓小莹，黄民. 中国健康汉族人孕烷X受体的基因多态性. 中国临床药理学杂志.2006,22(6):444-447.
17. 王长希，李嘉丽，陈思阳，陈立中，刘龙山，滕立臣，费继光，邓素雄，李军，邱江，陈国栋，黄民. 在不同CYP3A5基因型肾移植受体中地尔硫卓对他克莫司药代动力学的影响.2008, 中国器官移植峰会，学术论文. 优秀论文二等奖
18. 王雪丁，邓小莹，李嘉丽，陈杰，黄民.中国汉族人孕烷X受体基因NR1I2的单核苷酸多态性. 中国药理学与毒理学杂志.2006,20(6):479-483.
19. 滕立臣，王长希，陈立中，李嘉丽，费继光，邓素雄，邱江，李军，陈国栋. 受者CYP3A5基因多态性对肾移植术后早期血他克莫司浓度的影响. 中华器官移植杂志.2009,30(5):261-263
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