黄蓬 - 中山大学 - 肿瘤防治中心

个人简介

黄蓬，博士、博士生导师，广东省创新领军人才，现任中山大学肿瘤防治中心教授。1982年12月毕业于中山医科大学临床医学系，1990年获得美国德州大学生物医学研究生院理学博士学位，1995受聘于美国肿瘤学排名第一的德州大学MD Anderson癌症中心，2007成为该中心的终身正教授，并获得Ashbel Smith Endowed Professor 冠名教授荣誉称号。

研究领域

肿瘤代谢生物学和抗癌新药研发，他在肿瘤细胞的线粒体功能失调、糖酵解及能量代谢异常、氧化还原/活性氧的研究以及研发相应的抗癌新药等

近期论文

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Yuan S, Wang F, Chen G, Zhang H, Feng L, Wang L, Colman H, Keating MJ, Li X, Xu RH, Wang J, Huang P*.Effective elimination of cancer stem cells by a novel drug combination strategy. Stem Cells 2013 31(1):23-34. (IF 7.781) Xu RH, Huang P*. A new role for PHD in chemotherapy. Cancer Cell. 2012 22(2): 143-144. (IF 26.566). Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P*. K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res. 2012 22(2):399-412. (IF 8.19) Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P*. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 2012;10(5):e1001326. (IF 11.452) Zhang W., Trachootham D., Liu J., Chen G., Pelicano H., Garcia-Prieto C., Lu W., Burger J. A., Croce C. M., Plunkett W., Keating M. J., Huang P*. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat. Cell Biol. 2012. 14(3). 276-286. (IF:19.488) Lu W., Pelicano H., Huang P*. Cancer metabolism: is glutamine sweeter than glucose?. Cancer Cell 2010. 18(3). 199-200.(IF: 26.566) Trachootham D., Alexandre J., Huang P*. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009. 8(7). 579-591. (IF: 29.008) Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P*.Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood. 2008 112(5):1912-1922. (IF 9.898) Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P. J., Achanta G., Arlinghaus R. B., Liu J., Huang P*. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 2006. 10(3). 241-252. (IF: 26.566) Huang P*., Feng L., Oldham E. A., Keating M. J., Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000. 407(6802). 390-395 (IF: 36.28)