邹永 - 中山大学

个人简介

1988年毕业于在四川大学化学系有机化学专业，获学士学位。1988年至1990年在成都油脂化工总厂工作。1993毕业于华西医科大学药学院药物化学专业，获硕士学位。1997年毕业于华西医科大学药学院药物化学专业，获博士学位。1997年至1999年在中国科学院上海药物研究所博士后流动站从事博士后研究工作。1999年至2014年在中国科学院广州化学研究所（于2001年12月整体转制为中科院广州化学有限公司）工作，历任副研究员、研究员、教授、博士生导师。2001年12月-2009年8月任中科院广州化学有限公司副总经理。2001年12月-2004年3月及2009年8月-2012年7月任中科院广州化学有限公司董事。2009年10-11月赴美国伊利诺理工大学(IIT)进修和培训。2014年3月，入选中山大学引进人才，现任中山大学药学院教授、博士生导师。工作经历担任广东省人民政府驻企业科技特派员并担任大型制药企业技术顾问并保持长期合作，任广东省化学学会理事、中国药学会高级会员、广东省药学会会员、广东高校手性药物工程技术研究中心技术委员会委员。曾担任九三学社广州化学研究所支社主委（2002.03-2014.03）、广东省第九届青年联合会委员、广州市天河区第五届、第六届政协常委。

研究领域

主要从事中枢神经系统药物、抗肿瘤药物、心脑血管病药物及老年病药物的创新设计与合成；二苯乙烯类系列天然产物及衍生物的研究开发；新型前体药物的开发；特色可再生资源的多样化转化及高值化利用；药物及天然产物绿色合成工艺及方法学研究；仿制药物及功能性医药精细化学品的合成及开发

近期论文

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Qianzhong Zhang, Yi Jiang, Yinwu Li, Xianheng Song, Xiang Luo, Zhuofeng Ke, Yong Zou*. Design, synthesis, and physicochemical study of a biomass-derived CO2 sorbent 2, 5-furan-bis(iminoguanidine). iScience, 2021, 24(4): 102263 (Invited Paper). Jianheng Li#, Baijiao An#, Xianheng Song, Qianzhong Zhang, Chun Chen, Shuxian Wei, Runzhu Fan, Xingshu Li, Yong Zou*. Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors. Eur. J. Med. Chem., 2021, 212, 113019. Zefeng Zhu, Chun Chen, Jingxing Jiang, Qianzhong Zhang, Zhibo Du, Shuxian Wei, Xianheng Song, Jie Tang, Jinping Lei, Zhuofeng Ke, Yong Zou*. Synthesis and biological evaluation of suffrutines A, B and their N-fused analogues. Org. Chem. Front., 2020, 7(9): 1122–1131. Xiang Luo, Xianheng Song, Wenfang Xiong, Jianheng Li, Mingkang Li, Zefeng Zhu, Shuxian Wei, Albert S. C. Chan, Yong Zou*. Copper-Catalyzed C-H Carbamoyloxylation of Aryl Carboxamides with CO2 and Amines at Ambient Conditions. Org. Lett., 2019, 21(7): 2013−2018 (Highlighted by Synfacts 2019, 15(05), 0504). Xianheng Song, Xiang Luo, Jianfei Sheng, Jianheng Li, Zefeng Zhu, Zhibo Du, Hui Miao, Meng Yan, Mingkang Li, and Yong Zou*. Copper-Catalyzed Intramolecular Cross Dehydrogenative Coupling Approach to Coumestans from 2'-Hydroxyl-3-arylcoumarins. RSC Adv., 2019, 9(30): 17391-17398. Xihua Huang#, Jie Liu#, Jianfei Sheng, Xianheng Song, Zhibo Du, Mingkang Li, Xuejing Zhang, Yong Zou*. Decarboxylation of α, β-unsaturated aromatic lactones: Synthesis of E-ortho- hydroxystilbenes from 3-arylcoumarins or isoaurones. Green Chem., 2018, 20(4): 804-808 (Back cover, Hot articles of 2018). Wen-Tao Wei, Jian-Fei Sheng, Hui Miao, Xiang Luo, Xian-Heng Song, Ming Yan, and Yong Zou*. Transition-Metal-Free Synthesis of Acridones via Base-Mediated Intramolecular Oxidative C-H Amination. Adv. Synth. Catal., 2018, 360(11): 2101-2106. Hui Cheng, Yong Zou, Xiang Luo, Xian-Heng Song, Zhen Yang. Enzymatic synthesis of catechol-functionalized polyphenols with excellent selectivity and productivity. Process Biochem., 2018, 70: 90–97. Jianfei Sheng, Zhihong Liu, Ming Yan, Xue-jing Zhang, Dejian Wang, Jun Xu and Ensheng Zhang, Yong Zou*. Biomass-involved Synthesis of N-Substituted benzofuro[2,3-d] pyrimidine-4-amines and Biological Evaluation as Novel EGFR Tyrosine Kinase Inhibitors. Org. Biomol. Chem., 2017, 15(23): 4971-4977. Jianfei Sheng, Tianlong Xu, Ensheng Zhang, Xuejing Zhang, Wentao Wei, and Yong Zou*. Synthesis of Coumestrol and Aureol. J. Nat. Prod. 2016 79 (10): 2749-2753. Dejian Wang, Ensheng Zhang, Tianlong Xu, Jianfei Sheng, Yong Zou*. Sequential C–C, C–O, and C–N Bond-Forming Reaction of Methyl (–)-3-Dehydroshikimate, Malononitrile, and Bromoalkanes: Simple Synthesis of 2-(Alkylamino)-3-cyanobenzofurans from a Biomass- Derived Substrate. Synlett, 2016, 27(2): 287–293. Tianlong Xu, Ensheng Zhang, Dejian Wang, Yan Wang, and Yong Zou*. Cu-catalyzed Consecutive Hydroxylation and Aerobic Oxidative Cycloetherification under Microwave Conditions: Entry to 2-Arylbenzofuran-3-carboxylic Acids. J. Org. Chem., 2015, 80(9): 4313-4324. Ensheng Zhang, Xue-jing Zhang, Wen Wei, Dejian Wang, Yuchen Cai, Tianlong Xu, Ming Yan and Yong Zou*. A biomass-involved strategy for the synthesis of N-arylated dibenzo[b,e][1,4]oxazepin-11(5H)-ones, acridones, 7, 12-dihydrodibenzo[b,e][1,4]oxazocin- 6H-ones and dibenzo[b,f]azepin-10(11H)-ones. RSC Adv., 2015, 5(7): 5288-5294. Hang Yang, Qing Xia, Yong Zou, Kefeng Wang, Wenqi Jiang* and Yuchen Cai*. M410, a combretastatin A4 analogue, disrupts microtubules and inhibits HIF-1α in human breast cancer cells. Oncology Reports, 2015, 34: 334-340. Mingyang Li, Ying Xie, Yong Ye, Yong Zou, Huanfeng Jiang, Wei Zeng*. Cu(I)-Catalyzed Transannulation of N-Heteroaryl Aldehydes or Ketones with Alkylamines via C(sp3)–H Amination. Org. Lett., 2014, 16 (23): 6232–6235. Ensheng Zhang, Xuejing Zhang, Yuchen Cai, Dejian Wang, Tianlong Xu, Jun Li, Ming Yan and Yong Zou*. Biomass-involved, facile and one-pot synthesis of N-aryl-2(3H)-benzo- xazolones from methyl 3-Dehydroshikimiate. RSC Adv., 2014, 4(73): 39020-39029. Ensheng Zhang, Tianlong Xu, Wen Wei,Tongkun Huang, Mu Yuan, Wei Zeng, Yong Zou*. Cascade Reaction between Methyl 3-Dehydroshikimate, Arylamines, and 2-Chloroalkyl Esters under Microwave Conditions: A Practical and Biomass-Based Synthesis of N-Aryl-1,4- benzoxazin-3-ones. Synthesis 2014, 46(9): 1167-1176. Ensheng Zhang, Tianlong Xu, Dejian Wang, Tongkun Huang, Mu Yuan, Jun Li, Yong Zou*. Consecutive reactions between methyl 3-dehydroshikimiate, amines and 1, 2-dichloroalkanes under microwave conditions: A practical, one-pot construction of N-substituted dihydrobenzoxazines. RSC Adv., 2014, 4(20): 10022-10027. Rui-Meng Yang, Yong Zou, Dan-Ping Huang, Sheng‑Sheng Lai, Xiang‑Dong Xu, Xin‑Hua Wei, Han-Zheng Chang, Tong‑Kun Huang, Li Wang, Wen-Jie Tang, Xin-Qing Jiang. In vivo assessment of the vascular disrupting effect of M410 by DCE-MRI biomarker in a rabbit model of liver tumor. Oncology Reports 2014, 32(2): 709-715. De-Dong Li, Lan-Xue Zhao, Eleftherios Mylonakis, Gan-Hai Hu, Yong Zou, Tong-Kun Huang, Lan Yan, Yan Wang*, Yuan-Ying Jiang*. In vitro and in vivo activity of pterostilbene against Candida albicans biofilms. Antimicrob. Agents Chemother., 2014 58(4): 2344-2355.