文石军 - 中山大学

研究领域

目前主要研究方向是针对肿瘤细胞异常的代谢以及表观遗传进行酶抑制剂的设计与合成研究、以及探索新的合成方法来构建重要的抗肿瘤药物分子、使用基于小分子片段和天然产物策略进行组蛋白修饰酶、己糖激酶II、GAPDAH、和NAD(P)H抑制剂的研究。

近期论文

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1. Zhu D, Wu Y, Wu B, Luo B, Ganesan A, Pi R, Wu F-H, Huang P, Wen S*. Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes. Organic Letters 2014, online, DOI: 10.1021/ol5006714.（IF 6.14） 2. Li M, Luo B, Liu Q, Hu Y, Ganesan A, Huang P, Wen S*. Synthesis of N-acyl-N,O-acetals Mediated by Titanium Ethoxide. Org. Lett. 2014, 16, 10-13.（IF 6.14） 3. Zhu D, Liu Q, Luo B, Chen M, Pi R, Huang P, Wen S*. Synthesis of Carbazoles via One-Pot Copper-Catalyzed Amine Insertion into Cyclic Diphenyleneiodoniums as a Strategy to Generate a Drug-Like Chemical Library. Adv. Synth. Catal. 2013, 355, 2172-2178.（IF 5.54） 4. Zhu D, Chen M, Li M, Luo B, Zhao Y, Huang P, Xue F, Rapposelli A, Pi R, Wen S*. Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity. Eur. J. Med. Chem. 2013, 68, 81-88.（IF 3.50） 5. Guan R, Xu X, Chen M, Hu H, Ge H, Wen S*, Zhou S, Pi R. Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors. Eur. J. Med. Chem. 2013, 70, 613-622.（IF 3.50） 6. Wen S, Zhu D, Huang P. Targeting Cancer Cell Mitochondria as a Therapeutic Approach, Future Med. Chem., 2013, 5(1):53-67.（IF 3.31） 7. Zhou B, Zuo Y, Li B, Wang H, Liu H, Wang X, Qiu X, Hu Y, Wen S, Du J, Bu X. Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analogue AC17 Causes NF-κB Inhibition and p53 Reactivation in Human Lung Cancer Cells. Mol Cancer Ther. 2013, 12(8):1381-92.（IF 5.23） 8. Li X, Lu W, Hu Y, Wen S, Qian C, Wu W, Huang P. Effective inhibition of nasopharyngeal carcinoma in vitro and in vivo by targeting glycolysis with oxamate. Int. J. Oncol. 2013, 43(5): 1710-1718.（IF 2.40） 9. Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE 3rd, Sherman DR, Boshoff HI, Mizrahi V. Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening. Chem Biol. 2012, 27, 19(7), 844-54.（IF 5.83） 10. Tiffon, C., Adams, J., van der Fits, L., Wen, S., Townsend, P., Ganesan, A., Hodges, E., Vermeer, M., Packham, G. The histone deacetylase inhibitors Vorinostat and Istodax downmodulate IL10 expression in cutaneous T-cell lymphoma cells British Journal of Pharmacology, 2011, 162, 1590-1602.（IF 4.41） 11. Hung, A.W., Silvestre, H.L., Wen, S., Ciulli, A., Blundell, T.L., Abell, C. Application of fragment growing and fragment linking to the discovery of novel inhibitors of Mycobacterium tuberculosis pantothenate synthetase Angew. Chem. Int. Ed. 2009, 48, 8452-8456.（IF 13.46） 12. Heikkila, T.J., Surade, S., Silvestre, H.L., Dias, M.V.B., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A.H., Osborne, D., Abell, C., Blundell, T.L. Fragment-based drug discovery in academia: experiences from a tuberculosis programme NATO Security through Science Series C: Environmental Security, 2009, 21-36. 13. Wen, S., Packham, G., Ganesan, A., Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor J Org Chem, 2008, 73, 9353-9361.（IF 4.56） 14. Wen, S., Carey, K., Nakao, Y., Fusetani, N., Packham, G., Ganesan, A., Total Synthesis of Azumamide A and Azumamide E, Evaluation as Histone Deactylase Inhibitors, and Design of a More Potent Analogue Organic Letters 2007, 9 (6), 1105-1108. （IF 6.14） 15. Yurek-George, A., Cecil, A., Mo, A.H.K., Wen, S., Rogers, H., Maeda, S., Yoshida, M., Packham, G., Ganesan, A., The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor, J. Med. Chem., 2007; 50(23); 5720-5726.（IF 5.61） 16. Wen, S.-J., Hu, T.-S., Yao, Z.-J., Macrocylization Studies and Total Synthesis of Cyclomarin C, an Anti-inflammatory Marine Cyclopeptide, Tetrahedron, 2005, 61 (21), 4931-4938.（IF 2.80） 17. Wen, S.-J., Yao, Z.-J., Total Synthesis of Cyclomarin C. Organic Letters 2004, 6 (16) 2721-2724.（IF 6.14） 18. Wen, S.-J.; Zhang, H.-W.; Yao, Z.-J. Synthesis of a fully protected (2S, 3R)-N-(1',1'-dimethyl-2'- propenyl)-3-hydroxy-tryptophan from tryptophan Tetrahedron Lett. 2002, 43 (30) 5291-5294.（IF 2.40）