罗海彬 - 中山大学

个人简介

教育经历 1995.09－1999.07厦门大学化学系，学士 1999.09－2002.07厦门大学化学系，硕士 2002.10－2005.12香港浸会大学化学系，博士工作经历 2005.12－2006.12香港浸会大学化学系，博士后 2006.11－2011.12中山大学药学院药物化学 2008.07－2008.10弗吉尼亚大学医学院，访问学者 2009.06－2009.09弗吉尼亚大学医学院，访问学者 2011.12－迄今中山大学药学院，教授 2012.06－2014.04中山大学药学院，院长助理 2012.08－迄今中山大学药学院，博导 2014.04－迄今中山大学药学院，副院长

研究领域

从事抗老年性痴呆、肺动脉高压、糖尿病、哮喘等药物靶标结构生物学和发现研究，重点构建基于靶标磷酸二酯酶（PDE）的药物筛选体系，并进行相关的药物分子设计、有机合成和作用机制研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wu, D.W.; Zhang, T.H.; Chen, Y.; Huang, Y.; Geng, H.; Yu, Y.; Zhang, C., Lai, Z.W.; Wu, Y.; Guo, X.; Chen, J. W.*; Luo, L.-B.* Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension. J. Med. Chem. 2017, DOI: 10.1021/acs.jmedchem.7b00523. Huang, Y.; Liu, X.; Wu, D.; Tang, G.; Lai, Z.; Zheng, X. *; Yin. S. *; Luo, H.-B. * The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata. Biochem. Pharmacol. 2017, 130, 51-59. Zhang, C.; Feng, L.J.; Huang, Y.; Wu, D.; Li, Z.; Zhou, Q.; Wu, Y. *; Luo, H.-B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. J. Chem. Inf. Model. 2017, 57, 355-364. Cai, Y. H. #; Guo, Y. #; Li, Z.; Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun, Z.; Luo, H.-B.; Yin, S.*; Wu, Y*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur. J. Med. Chem. 2016, 114, 134-140. Wu, Y.; * Cheng, J.; Wu, D.; Gu, Q.; Luo, Z.Y.; Luo, H.-B.* Palladium-catalyzed C–H bond carboxylation of acetanilides: an efficient usage of N,N-dimethyloxamic acid as the carboxylate source. Chem. Commun. 2016, 52, 1286-1289. PMID: 26616015 Su, T.; Zhang, T.; Xie, S.; Yan, J.; Wu, Y.; Li, X.; Huang, L.*; Luo, H.-B. *. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease. Sci. Rep. 2016, 6:21826. PMID: 26911795 Wu, Y.*; Sun, L.; Chen, Y.; Zhou, Q.; Huang, J.W.; Miao, H.; Luo, H.-B.* Palladium-Catalyzed Decarboxylative Acylation of N-Nitrosoanilines with α-Oxocarboxylic Acids. J. Org. Chem. 2016, 81(3):1244-1250. PMID: 26746881 Li, Z.; Wu, Y., Feng, L.J.; Wu, R.*; Luo, H.-B.* Ab Initio QM/MM Study Shows a Highly Dissociated SN2 Hydrolysis mechanism for the cGMP-specific phosphodiesterase-5. J. Chem. Theory Comput. 2015, 10, 5448-5457. Huang, M.; Shao, Y.; Hou, J.; Cui, W.; Liang, B.; Huang, Y.; Li, Z.; Wu, Y.; Zhu, X.; Liu, P.; Wan, Y.*; Ke. H.*; Luo, H.-B.* Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol. Pharmacol. 2015, 88(5):836-845. PMID: 26316540 Zhou, J.; Wu, R.*; Luo, H.-B.* Inhibition mechanism of SAHA in HDAC: a revisit. Phys. Chem. Chem. Phys. 2015, 17(44):29483-29488. PMID: 26497064 Li, Z.; Lu, X.; Feng, L.J.; Gu, Y.; Li, X.; Wu, Y.;* Luo, H.-B.* Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds. Mol. Biosyst. 2015, 15, 115-125. PMID: 25328054. Shao, Y.X.; Huang, M.; Cui, W.; Feng, L.J.; Wu, Y.; Cai, Y.; Li, Z.; Zhu, X.; Liu, P.; Wan, Y.;* Ke, H.*; Luo, H.-B.* Discovery of a phosphodiesterase-9A inhibitor as a potential hypoglycemic agent. J. Med. Chem. 2014, 57, 10304-130313. PMID: 25432025. Shang, N.N.; Shao, Y.X.; Cai, Y.H.; Guan, M.; Huang, M.; Cui, W.; He, L.; Yu, Y.J.; Huang, L.; Li, Z.; Bu, X. Z.*; Ke, H.*; Luo, H.-B.* Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochem. Pharmacol.2014, 89: 86-98. PMID:24565909 Wu, Y.; Feng, L.J.; Lu, X.; Kwong, F.Y.*; Luo, H.-B.* Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones. Chem. Commun. 2014, 50(97), 15352-15354. PMID: 25348462 Zhou, J., Xie, H.; Liu, Z.;Luo, H.-B.*; Wu, R.* Structure-Function Analysis of the Conserved Tyrosine and Diverse π-Stacking among Class I Histone Deacetylases: A QM (DFT)/MM MD Study. J. Chem. Inf. Model. 2014, 54(11), 3162-3171. PMID: 25360823 Liu, X.(#); Luo, H.-B.(#,并列第一作者); Huang, Y.Y.; Bao, J.M.; Tang, G.H.; Chen, Y.Y.; Wang, J.; Yin, S. Selaginpulvilins A-D, New phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella Pulvinata. Org. Lett. 2014, 162, 282-285. PMID: 24328835. Cheng, Z.B.; Lu, X.; Bao, J. M.; Han, Q.; Tang, G.H.; Gan, L.S. *; Luo, H.-B.*; Yin, S.* (±)-Torreyunlignans A.D, Rare 8-9’ Linked Neolignan Enantiomers as Phosphodiesterase-9A Inhibitors from Torreya yunnanensis. J. Nat. Prod. 2014, 77, 2651−2657. Cheng, Z.B.; Deng, Y.L.; Fan, C.Q.; Han, Q.H.; Lin, S.L.; Tang, G.H.; Luo, H.-B.*; Yin, S.* Prostaglandin Derivatives: Nonaromatic Phosphodiesterase-4 Inhibitors from the Soft Coral Sarcophyton ehrenbergi. J. Nat. Prod. 2014, 77, 1928–1936. PMID: 25075977 Lin, T.T.; Huang, Y.Y.; Tang, G.H.; Cheng, Z.B.; Liu, X.; Luo, H.-B.*; Yin, S.* Prenylated Coumarins: Natural Phosphodiesterase-4 Inhibitors from Toddalia asiatica. J. Nat. Prod. 2014, 77: 955-962. PMID:24597921 Liu, Y.N.; Huang, Y.Y.; Bao, J.M.; Cai, Y.H.; Guo, Y.Q.; Liu, S.N.; Luo, H.-B.*; Yin, S.* Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria Ferruginea. Fitoterapi 2014, 94: 177-182. PMID:24594242