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Jinhui Hu, Tingting Pan, Baijiao An, Zhengcunxiao Li , Xingshu Li*, Huang, Ling*. Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease. Eur. J. Med. Chem., 2019, 512− 526.
Jinhui Hu, , Ya-Dan Huang, Tingting Pan, Tianhua Zhang , Tao Su, Xingshu Li , Hai-Bin Luo, * Ling Huang,*. Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease. ACS Chem. Neurosci, 2019, 10, 537−551.
Tingting Pan, Shishun Xie, Yan Zhou, Huijin Hu, Haibin Luo, Xingshu Li, Ling Huang *. Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo [3,4-b] pyridine hybrids. Bioorg. Med. Chem. Lett, 2019, 29 (16), 2150-2152
Zhiren Wang, Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu Li,* Ling Huang,* and Albert S. C. Chan. Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline–Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2018, 61, 1871-1894.
Baijiao An, Bo Wang, Jinhui Hu, Shaoyu Xu, Ling Huang,* Xingshu Li,* and Albert S. C. Chan. Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents. J. Med. Chem. 2018, 61, 2571-2588.
Jinhui Hu, Baijiao An, Tingting Pan, Zhengcunxiao Li, , Huang, Ling*, Xingshu Li. Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease, Bioorg Med Chem, 2018, 26, 5718-5729.
Chuan-Jun Lu, Jinhui Hu, Zechen Wang, Shishun Xie, Tingting Pan, LingHuang*, Xingshu Li. Discovery of boron-containing compounds as Aβ aggregationinhibitors and antioxidants for the treatment of Alzheimer's disease, MedChemComm, 2018, 9, 1862-1870.
Shun Zhang, Baijiao An, Jiayan Li, Jinhui Hu, Ling Huang,* Xingshu Li * and Albert S. C. Chan. Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents. Org. Biomol. Chem., 2017, 15, 7404 – 7410.
Jun Yan, Jie Chen, Shun Zhang, Jinhui Hu, Ling Huang,* and Xingshu Li*. Synthesis, Evaluation, and Mechanism Study of Novel IndoleChalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo. J. Med. Chem. 2016, 59, 5264−5283.
Tao Su, Tianhua Zhang, Shishun Xie, JunYan, Yinuo Wu, Xingshu Li, Ling Huang,* and Hai-Bin Luo *. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease. Sci. Rep. 2016, (6), 1-14. Zhiren Wang, Wenrui Li, Yali Wang, Xiruo Li, Ling Huang,* Xingshu Li*. Design, synthesis and evaluation of clioquinol-ebselen hybrids as multi-target-directed ligands against Alzheimer's disease. RSC Adv. 2016, 7139-7158.
Yali Wang, Yang Sun, Yueyan Guo, Zechen Wang, Ling Huang*, Xingshu Li. Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives. J. Enzyme. Inhib. Med. Chem. 2016, 31(3), 389-397.
Zhiren Wang, Yali Wang, Bo Wang, Wenrui Li, Ling Huang,* and Xingshu Li*. Design, Synthesis and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multi-Target-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease. J. Med. Chem. 2015, 8616–8637.
Zhiren Wang, Yali Wang, Wenrui Li, Zhihong Liu, Zonghua Luo, Yang Sun, Ruibo Wu, Ling Huang,* and Xingshu Li*. Computer-assisted designed “selenoxy–chinolin”: a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation. Dalton Trans., 2015, 44, 20913-25.
Jun Yan, Yueyan Guo, Yali Wang, Fei Mao, Ling Huang*, ,Xingshu Li *. Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents. Eur. J. Med. Chem. 2015, 95, 220-229.
Jun Yan, Yanqing Pang, Jie Chen, Jianfei Sheng, Jinhui Hu, Ling Huang,* and Xingshu Li*. Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents. RSC Adv. 2015, 98527-98537.
Jie Chen, Jun Yan, Jinhui Hu, Yanqing Pang, Ling Huang*, Xingshu Li*. Synthesis, Biological Evaluation and Mechanism Study of Chalcone Analogues as Novel Anti-cancer Agents. RSC Adv. 2015, 5, 68128-68135.
Shishun Xie, Jie Chen, Xiruo Li, Tao Su, Yali Wang, Zhiren Wang, Ling Huang*, Xingshu Li*. Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease. Bioorg. Med. Chem., 2015, 23, 3722–3729.
Jinhui Hu, Jun Yan, Jie Chen, Yangqing Pan, Ling Huang*, ,Xingshu Li *.Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents. MedChemComm., 2015,6, 318-1327.
Tao Su, Shishun Xie, Bifu Li, Jun Yan, Ling Huang,* Xingshu Li*. Copper-catalyzed three-component one-pot synthesis of substituted 2-aryl-1,3-benzoselenazoles. Synlett. 2015, 26, 215-220.
Fei Mao, Jianheng Li, Hui Wei, Ling Huang,* Xingshu Li*. Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease. J. Enzyme. Inhib. Med. Chem. 2015, 995-1001. Zhiren Wang , Yali Wang, Wenrui Li, Fei Mao, Yang Sun, Ling Huang*, ,Xingshu Li *. Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease. ACS Chem. Neurosci. 2014, 5, 952− 962.
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