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1. Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-quadruplex DNA，J. Med. Chem., 2009, 52，2825-2835. 2. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation, J. Med. Chem. 2008, 51, 6381- 6392. 3. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives，J. Med. Chem. 2007, 50, 1465-1474. 4. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase，J. Med. Chem. 2005, 48, 7315. 5. Senesence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503. 6. Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells, Leukemia, 2007, 1-3. 7. G-quadruplexes: a target for anti-cancer drug design,ChemMedChem，2008, 3, 690-713. 8. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors, Bioorg. Med. Chem., 2008, 16, 8035-8041. 9. Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives, Bioorg. Med. Chem. 2008, 16, 4617-4325. 10. 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc, Bioorg. Med. Chem., 2008, 16, 7582-7591. 11. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA, Bioorg. Med. Chem.2007, 15, 5493-5501. 12. Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands, Bioorg. Med. Chem. Lett, 2009, 19, 3414-3417. 13. Synthesis and antimultidrug resistance evaluation of icariin and its derivatives, Bioorg. Med. Chem. Lett, 2009, 19, 4237-4240. 14. Inhibition of thioredoxin reductase by curcumin analogs, Biosci. Biotech. Biochem., 2008, 72, 2214-2218. 15. Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors, Bioorg. Med. Chem., 2008, 16, 3790-3793. 16. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines, Heterocycles, 2008, 75, 1773-1778. 17. Oxoisoaporphine Alkaloid Derivatives: Synthesis, DNA Binding Affinity and Cytotoxicity, Eur. J. Med. Chem., 2008, 43, 973-980. 18. Synergetic inhibition of metal ions and genistein on a-glucosidase，FEBS Letters, 2004, 576, 46-50. 19. Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetycholinesterase inhibitors, Bioorg. Med. Chem. Lett. 2007, 17, 3765-3768. 20. Synergetic inhibition of genistein and a-glucose on a-glucosidase，Bioorg. Med. Chem. Lett. 2004, 14, 2947-2950.