个人简介
Ph.D. (2011) University of California, Irvine
研究领域
Chemical Biology/Synthesis and Catalysis
Natural products and their synthetic derivatives have historically provided a rich source of pharmaceutical drug leads. Inspired by the application(s) of secondary metabolites in human disease, research in the Frederich laboratory focuses on developing new strategies and methods to prepare architecturally complex molecules that exhibit important biological activity in living systems. A critical aspect of this endeavor involves designing new reactions that build molecular complexity, thereby allowing us to approach challenging structures in a practical way. Access to targeted natural products and designed synthetic variants will open exciting avenues to explore their pharmacology. At this stage, exercises in molecular biology, biophysics and medicinal chemistry will become part of interdisciplinary research aimed at translating new discoveries in complex molecule synthesis to potentially new therapy for human disease.
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
James H. Frederich and Patrick G. Harran. "Modular Access to Complex Prodiginines: Total Synthesis of (+)-Roseophilin via its 2-Azafulvene Prototropisomer." J. Am. Chem. Soc. 2013, 135, 3788.
James H. Frederich, Patrick G. Harran, Mai Nguyen and Gordon Shore. "Mcl-1 Antagonists." US Patent 61947211, 2014.
James. H. Frederich, Jennifer K. Matsui, Randy O. Chang and Patrick G. Harran. "Substituted 2,2'-Bipyrroles and Pyrrolylfurans via Intermediate Isoxazolylpyrroles." Tetrahedron Lett. 2013, 54, 2645.
Jeffrey S. Cannon, James H. Frederich and Larry E. Overman. "Palladacycle Imidazoline-naphthalene Complexes: Synthesis and Catalytic Performance in Pd(II)-Catalyzed Reactions of Allylic Trichloroacetimidates." J. Org. Chem. 2012, 77, 1939.