魏静 - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 2001-2004 Master of Engineering Pattern Recognition and Intelligence System Tianjin University, CN 2004-2007 Doctor of Engineering Medicinal Chemistry Tianjin University CN Professional Experience： 2007-今 lecturer Tanjin University , China 1995-2001 Physician Laboratorian of Center for Disease Control and Prevention, Hexi District, Tianjin Honors and Awards：魏静，四乙酰核糖和二乙酰阿昔洛韦合成的新工艺，天津市人民政府，科技进步奖，二等奖，2009。（赵康、陈维瑜、魏静、杜云飞、王松青、苏艳芳、张秀东、陈炎泉）魏静，第十三届“挑战杯”天津市大学生课外学术科技作品竞赛优秀指导教师，天津市委员会、天津市科学技术委员会、天津市教育工作委员会等，2015。

研究领域

Wei’s research addresses mechanisms of drug activity with associated drug design. Computational approaches (e.g., molecular docking, pharmacophore modeling, quantitative structure-activity relationship (QSAR), molecular dynamics) are used to identify and characterize putative ligand binding sites, elucidate binding mechanisms, and guide rational design of potentially new drugs.

近期论文

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Distinct binding mode of BAFF antagonist antibodies belimumab and tabalumab, analyzed by computer simulation Jiang Yaxin,Sun Jian,Wei Jing ISSN:1610-2940 2022 Container-title:Journal of Molecular Modeling New therapeutic strategies based on biasing IL-2 mutants for cancers and autoimmune diseases Dongfu Jin , Yaxin Jiang , Lu Chang , Jing Wei , Jian Sun International Immunopharmacology，Volume 110, September 2022, 108935 Analysis of the molecular mechanism of SARS-CoV-2 antibodies Jin Dongfu,Wei Jing,Sun Jian Page:45-52 ISSN:0006-291X 2021 Container-title:Biochemical and Biophysical Research Communications Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy Zhao Haodi,Wei Jing,Sun Jian Page:107101 ISSN:1567-5769 2020 Container-title:International Immunopharmacology Study on the Mechanism of Selective Interaction of BR3 and BCMA with BAFF and APRIL Protein & Peptide Letters 2020-11-16 | Journal article DOI: 10.2174/0929866527666200413101757 CONTRIBUTORS: Luoman Li; Yaxin Jiang; LiLi Su; Deming Feng; Jing Wei; Jian Sun Construction of small molecular CTLA4 analogs with CD80-binding affinity Liu Fang,Su LiLi,Chen Ziteng,Feng Deming,Wei Jing,Sun Jian Page:694-700 ISSN:0006-291X 2019 Container-title:Biochemical and Biophysical Research Communications In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6 Yonghao Qi, Xuan Zhao, Jiaying Chen, Ambara R. Pradipta, Jing Wei, Haihua Ruan, Lijun Zhou, Richard P. Hsung & Katsunori Tanaka Bioscience, Biotechnology, and Biochemistry, Volume 83, Issue 6, 3 June 2019, Pages 1011–1026, https://doi.org/10.1080/09168451.2018.1559030 Study of the molecular mechanism of interleukin-2 mutein D10 binding to IL-2 receptors by molecular simulations Zhuo Mao,Xuegang Fu,Zeyun Dong,Xiaodong Jian,Jian Sun &Jing Wei Pages 973-980 | Received 01 Feb 2018, Accepted 15 Apr 2018, Published online: 27 Apr 2018 Cite this article https://doi.org/10.1080/08927022.2018.1467013 Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice Meng Xiaolu,Mao Zhuo,Li Xin,Zhong Dandan,Li Min,Jia Yingli,Wei Jing,Yang Baoxue,Zhou Hong Page:40305-40317 ISSN:1949-2553 2017 Container-title:Oncotarget N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β–activated kinase 1 activation Miao Li, Yonghao Qi, Jing Wei, Lulu Lu, Xuan Zhao and Lijun Zhou Page:101042831769596 ISSN:1010-4283 2017 Container-title:Tumor Biology