华国强 - 复旦大学 - 肿瘤研究所

个人简介

2008毕业于中国科学院生物物理研究所获肿瘤生物学博士学位。2009至2014年在美国纪念斯隆凯特琳肿瘤研究中心(Memorial Sloan-Kettering Cancer Center)从事肠道干细胞损伤再生。2015年至今受聘复旦大学上海医学院和复旦大学附属肿瘤医院组建干细胞再生生物学实验室。课题组目前研究的重点是癌症患者的个性化精准治疗和组织损伤再生。与传统研究手段不同，课题组依托于最新的干细胞类器官（organoid）培养技术(正常组织类器官和肿瘤类器官)，并在此基础进行多种抗肿瘤药物和正常组织促再生新药的高通量筛选。建立患者来源的直肠癌类器官样本库，并通过临床试验验证直肠癌类器官能预测患者体内的放化疗效果。先后在国际知名杂志Cell Stem Cell、International Journal of Radiation Oncology/Biology/Physics、Stem Cell Reports、Ebiomedicine、Protein & Cell、Cancer Research、Cancer Letters、Carcinogenesis、中国科学等杂志上发表研究工作, 其中Cell Stem Cell的文章被ESI评为高被引用文章。

研究领域

肿瘤类器官为基础的个性化精准治疗类器官为基础的高通量促再生药物筛选肠道上皮损伤再生修复机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Ye Yao#, Xiaoya Xu#, Lifeng Yang#, Ji Zhu, Juefeng Wan, Lijun Shen, Fan Xia, Guoxiang Fu, Yun Deng, Mengxue Pan, Qiang Guo, Xiaoxue Gao, Yuanchuang Li, Xinxin Rao, Yi Zhou, Liping Liang，Yaqi Wang, Jing Zhang, Hui Zhang, Lixing Zhang，Junjie Peng, Sanjun Cai, Chen Hu，Jianjun Gao, Hans Clevers, Zhen Zhang*, Guoqiang Hua*. Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer. Cell Stem Cell. 2020 Jan 2; 26(1):17-26. Yuanchuang Li#, Xinxin Rao#, Peiyuan Tang, Shengzhi Chen, Qiang Guo, Guoxiang Fu, Mengxue Pan, Liping Liang, Ye Yao, Xiaoxue Gao, Yi Zhou, Zhen Zhang, Xiaoya Xu, Jianjun Gao*, Guoqiang Hua*. Bach2 deficiency promotes intestinal epithelial regeneration by accelerating DNA repair in intestinal stem cells. Stem Cell Reports. 2021, Jan, Vol16: 1-14. Hu X#, Zhang L#, Li Y#, Ma X, Dai W, Gao X, Rao X, Fu G, Wang R, Pan M, Guo Q, Xu X, Zhou Y, Gao J, Zhang Z, Cai S*, Peng J*, Hua G*. Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signaling. EBioMedicine. 2020 Jun; 56:102800. Guoxiang Fu#, Shengzhi Chen#, Liping Liang, Peiyuan Tang, Xinxin Rao, Mengxue Pan, Xiaoya Xu, Qiang Guo, Yuanchuang Li, Ye Yao, Yi Zhou, Jun Gao, Shaobo Mo, Sanjun Cai, Junjie Peng, Zhen Zhang, Hans Clevers, Jianjun Gao, Guoqiang Hua*. SIRT1 Inhibitors Mitigate Radiation-induced GI Syndrome by Enhancing Intestinal-Stem-Cell Survival. Cancer letters. 2021 Mar 31; 501:20-30. Rao X#, Tang P#, Li Y#, Fu G, Chen S, Xu X, Zhou Y, Li X, Zhang L, Mo S, Cai S, Peng J, Zhang Z, Gao J, Hua G*. CBP/P300 Inhibitors Mitigate Radiation-Induced GI Syndrome by Promoting Intestinal Stem Cell-Mediated Crypt Regeneration. Int J Radiat Oncol Biol Phys. 2021 Feb 3: S0360-3016. Li Y#, Li J#, Wang R#, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G*, Peng J*, Yu FX*. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma. Protein Cell. 2020 Apr; 11(4):292-298. Li Y#, Wang R#, Huang D#, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S*, Hua G*, Peng J*. A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application. Carcinogenesis. 2020 Jul 14; 41(7):993-1004. Guo Q#, Chen S, Rao X, Li Y, Pan M, Fu G, Yao Y, Gao X, Tang P, Zhou Y, Xu X, Gao J*, Hua G*. Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. Am J Transl Res. 2019 Aug 15; 11(8):4789-4799. Li Y#, Tang P#, Cai S, Peng J, Hua G*. Organoid based personalized medicine: from bench to bedside. Cell Regen. 2020 Nov 2; 9(1):21.