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不对称催化合成新方法的开发及其在手性药物及中间体、活性天然产物合成中的应用。 具有生物活性杂环化合物的绿色合成新方法研究。 手性药物及其重要中间体的过程化学研究。

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Jun Deng, Xiao-Na Wang, and Richard P. Hsung*, Methods and Applications of Cycloaddition Reactions in Organic Syntheses (A Formal [3 + 3] Cycloaddition Approach to Natural Product Synthesis), John Wiley & Sons, Ltd. 2013, Chapter 12. Jun Deng, Richard P. Hsung*, Changhong Ko. Gassman’s Cationic [2 + 2] Cycloadditions Using Temporary Tethers. Organic Letters, 2012, 14, 5562-5565. John B. Feltenberger, Changhong Ko, Jun Deng, Sunil K. Ghosh, Richard P. Hsung*. Development of an Intramolecular Gassman's [2+2] Cycloaddition. Heterocycles, 2012, 84, 843-878. Jun Deng, Sermadurai Selvakumar & Mukund P. Sibi*, Zinc Trifluoromethanesulfonate (first update), The Encyclopedia of Reagents for Organic Synthesis [EROS], John Wiley & Sons, Ltd. 2011. Kyle A DeKorver, Whitney L Johnson, Yu Zhang, Richard P Hsung*, Hui-fang Dai, Jun Deng, Andrew G Lohse, Yan-Shi Zhang. N-Allyl-N-sulfonyl Ynamides as Synthetic Precursors to Amidines and Vinylogous Amidines. An Unexpected N-to-C 1,3-Sulfonyl Shift in Nitrile Synthesis. Journal of Organic Chemistry,2011, 76, 5092-5103. Chuan-Jin Hou, Wei-Lei Guo, Xiang-Ping Hu,* Jun Deng, Zhuo Zheng*. Chiral ferrocenyl phosphine-phosphoramidite ligands for Cu-catalyzed asymmetric conjugate reduction of alpha,beta-unsaturated esters. Tetrahedron: Asymmetry. 2011, 22, 195-199. Sai-Bo Yu, Xiang-Ping Hu*, Jun Deng, Dao-Yong Wang, Zheng-Chao Duan, Zhuo Zheng*. Enantioselective Ag(I)-catalyzed [3+2] cycloaddition of azomethine ylides using a chiral ferrocene-based phosphine–phosphoramidite ligand having a stereogenic P-center. Tetrahedron: Asymmetry, 2009, 20, 621-625. Dao-Yong Wang, Xiang.-Ping Hu*, Chuan-Jin Hou, Jun Deng, Zheng-Chao Duan, Jia-Di Huang, Zhuo Zheng*. Enantioselective Rh-catalyzed Hydrogenation of 3-Substituted 2-Phosphonomethyl-propenoates by a New Class of Chiral Ferrocenyl Diphosphine Ligands. Organic Letters, 2009, 11, 3226-3229. Dao-Yong Wang, Xiang-Ping Hu*, Jun Deng, Sai-Bo Yu, Zheng-Chao Duan, Zhuo Zheng*. Enantioselective Synthesis of Chiral ?-Aryl or??-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-type Ligand. Journal of Organic Chemistry, 2009, 74, 4408-4410. Zheng-Chao Duan, Xiang-Ping Hu*, Jun Deng, Sai-Bo Yu, Dao-Yong Wang, Zhuo Zheng*. Asymmetric synthesis of chiral glutaric acid derivatives via Rh-catalyzed enantioselective hydrogenation. Tetrahedron: Asymmetry, 2009, 20, 588-592. Jun Deng, Xiang-Ping Hu*, Jia-Di Huang, Sai-Bo Yu, Dao-Yong Wang, Zheng-Chao Duan, Zhuo Zheng*. Enantioselective Synthesis of ?2 -Amino Acids via Rh-Catalyzed Asymmetric Hydrogenation with BoPhoz-Type Ligands: Important Influence of an N-H Proton in the Ligand on the Enantioselectivity. Journal of Organic Chemistry, 2008, 73, 2015-2017. Jun Deng, Xiang-Ping Hu*, Jia-Di Huang, Sai-Bo Yu, Dao-Yong Wang, Zheng-Chao Duan, Zhuo Zheng*. Enantioselective Synthesis of???-Aryl-???-amino Acid Derivatives via Cu-Catalyzed Asymmetric 1,4-Reductions of ??-Phthalimido-Substituted ??,???-Unsaturated Carboxylic Acid Esters. Journal of Organic Chemistry,2008, 73, 6022-6024. Dao-Yong Wang, Jia-Di Huang, Xiang-Ping Hu*, Jun Deng, Sai-Bo Yu, Zheng-Chao Duan, Zhuo Zheng*. Readily Available Chiral Phosphine-Aminophosphine Ligands for Highly Efficient Rh-Catalyzed Asymmetric Hydrogenation of ?-Enol Ester Phosphonates and ??-Enamido Phosphonates. Journal of Organic Chemistry, 2008, 73, 2011-2014. Sai-Bo Yu, Xiang-Ping Hu*, Jun Deng, Jia-Di Huang, Dao-Yong Wang,Zheng-Chao Duan, Zhuo Zheng*. Ferrocene-based phosphine-triazine ligands for highly efficient Suzuki-Miyaura cross-coupling reaction of aryl chlorides. Tetrahedron Letters 2008, 49, 1253-1256. Min Qiu, Xiang-Ping Hu*, Dao-Yong Wang, Jun Deng, Jia-Di Huang, Sai-Bo Yu, Zheng-Chao Duan, Zhuo Zheng*. Chiral 1,2,3,4-Tetrahydro-1-naphthylamine-?Derived Phosphine-Phosphoramidite Ligand (THNAPhos): Application in Highly Enantioselective Hydrogenation of Functionalized C=C Bonds. Advanced Synthesis & Catalysis, 2008,350, 1413-1418. Dao-Yong Wang, Xiang-Ping Hu*, Jia-Di Huang, Jun Deng, Sai-Bo Yu, Zheng-Chao Duan, Xue-Feng Xu, Zhuo Zheng*. Highly Enantioselective Synthesis of ??-Hydroxy Phosphonic Acid Derivatives by Rh-Catalyzed Asymmetric Hydrogenation with Phosphine- Phosphoramidite Ligands. Angew. Chem. Int. Ed. 2007, 46, 7810-7813. Jun Deng, Zheng-Chao Duan, Jia-Di Huang, Xiang-Ping Hu*, Dao-Yong Wang, Sai-Bo Yu, Xue-Feng Xu, Zhuo Zheng*. Rh-Catalyzed Asymmetric Hydrogenation of ?-Phthalimido-Substituted ?,??-Unsaturated Carboxylic Acid Esters: An EfficientEnantioselective Synthesis of ??-Aryl-???-amino Acids. Organic Letters, 2007, 9, 4825-4828. Huang, Hanmin, Liu, Xiongcai, Deng Jun, Qiu, Min, Zheng, Zhuo*. Rhodium-Catalyzed Enantioselective Hydrogenation of ??-Phthalimide Acrylates to Synthesis of ?2 -Amino Acids. Organic Letters, 2006, 8, 3359-3362.

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