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Cheng X.; Peng K.; Chen B.; Shu Y*. A teenager with auricular infection secondary to piercing.BMJ. 2023 Mar 16;380:e071715.
Li Q.#*; Cui C.#; Liao R.; Yin X.; Wang D.; Cheng Y.; Huang B.; Wang L.; Yan M.; Zhou J.; Zhao J.; Tang W.; Wang Y.; Wang X.; Lv J.; Li J.; Li H.*; Shu Y.*. The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice. Cell Mol Life Sci. 2023 May 13;80(6):148.
Liu Q#, Zhang X#, Huang H#, Chen Y#, Wang F, Hao A, Zhan W, Mao Q, Hu Y, Han L, Sun Y, Zhang M, Liu Z，Zhang W，Shu Y*, Sun L*, Chen Z*. Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger. Nat Commun. 2023. (Accepted)
Jiang L.#; Wang D.#; He Y.*; Shu Y.*. Advances in gene therapy hold promise for treating hereditary hearing loss. Mol Ther. 2023 Apr 5;31(4):934-950.
Tang H.#; Wang H.#; Wang S.#; Hu SW.#; Lv J.; Xun M.; Gao K.; Wang F.; Chen Y.; Wang D.; Wang W.*; Li H.*; Shu Y.*. Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin. Hum Genet. 2023 Feb;142(2):289-304.
Xiao, Q.#;Xu, Z.#;Xue, Y.#;Xu, C.#;Han, L.;Liu, Y.;Zhang, P.;Wang, F.;Zhang, R.; Han, S.;Wang, X.;Li, G. L.; Li, H*.; Yang, H*.; Shu, Y*., Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor. Science Translational Medicine, 2022 Jul 20;14(654):eabn0449.
Gu, X.#;Hu, X.#;Wang, D.#;Xu, Z.;Wang, F.;Li, D.;Li, G. L.;Yang, H.;Li, H*.;Zuo, E*.; Shu, Y*., Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice. Cell Res,2022 Jul;32(7):699-702
Zheng, Y.#;Liu, H.#;Chen, Y.#;Dong, S.#;Wang, F.;Wang, S.;Li, G. L.;Shu, Y*.; Xu, F. *, Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron2022,110 (2), 237-247.e4.
Zheng, Z.#;Li, G.#;Cui, C.#;Wang, F.;Wang, X.;Xu, Z.;Guo, H.; Chen, Y.;Tang, H.;Wang, D.;Huang, M.;Chen, Z. Y.;Huang, X.;Li, H.;Li, G. L.*;Hu, X.*; Shu, Y.*, Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing. Signal Transduct Target Ther2022,7 (1), 79.
Xue Y.#; Hu X.#; Wang D.#; Li D.#; Li Y.; Wang F.; Huang M.; Gu X.; Xu Z.; Zhou J.; Wang J.; Chai R.; Shen J.; Chen ZY.; Li GL.; Yang H.; Li H.*; Zuo E.*; Shu Y.*. Gene editing in a Myo6 semi-dominant mouse model rescues auditory function. Mol Ther. 2022 Jan 5;30(1):105-118.
Gu, X.#;Wang, D.#;Xu, Z.#;Wang, J.;Guo, L.;Chai, R.;Li, G.;Shu, Y.*; Li, H.*, Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing. Genome Biol2021,22 (1), 86.
Cui C.#; Wang D.#; Huang B.#; Wang F.#; Chen Y.; Lv J.; Zhang L.; Han L.; Liu D.; Chen ZY.; Li GL.; Li H.; Shu Y*. Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss, Mol Ther Nucleic Acids, 2022 Jul 20;29:400-412.
Wang J.; Wang C.; Wang Q.; Zhang Z.; Wang H.; Wang S.; Chi Z.; Shang L.*; Wang W.*; Shu Y.* Microfluidic Preparation of Gelatin Methacryloyl Microgels as Local Drug Delivery Vehicles for Hearing Loss Therapy. ACS Appl Mater Interfaces. 2022 Oct 19;14(41):46212-46223.
Tang H.; Wang D.; Shu Y*.Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants. Signal Transduct Target Ther. 2022 Aug 4;7(1):271.
Guo, Y.#;Han, L.#;Han, S.;Tang, H.;Wang, S.;Cui, C.;Chen, B.*;Li, H.*; Shu, Y.*, Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice. Mol Ther Nucleic Acids2022,28, 643-655.
Wang, J.;Zhao, L.;Gu, X.;Xue, Y.;Wang, S.;Xiao, R.;Vandenberghe, L.;Peng, K. A.;Shu, Y*.; Li, H*., Efficient delivery of adeno-associated virus (AAV) into inner ear in vivo via trans-stapes route in adult guinea pig. Human Gene Therapy,2022 Jul;33(13-14):719-728. (Cover story)
Zhang K.#; Cheng X.#; Zhao L.#; Huang M.; Tao Y.; Zhang H.; Rosenholm JM.; Zhuang M.; Chen ZY.; Chen B.*; Shu Y*. Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo. Mol Ther Methods Clin Dev. 2020 Jun 30;18:511-519.
Bing Wang; Tianwen Xin, Lang Shen, Kun Zhang, Dan Zhang, Hui Zhang, Jisheng Liu, Bing Chen*,Wenguo Cui*, Yilai Shu*. Acoustic transmitted electrospun fibrous membranes for tympanic membrane regeneration. Chemical Engineering Journal,27 March 2021,129536.
Yilai Shu#, Wenyan Li#, Mingqian Huang#, Yi-Zhou Quan#, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Zhengmin Wang, Huawei Li and Zheng-Yi Chen. Renewed proliferation in adult mouse cochlea and regeneration of hair cells, Nature communications. 2019 Dec 4;10(1):5530.
Cheng, X.;Liu, J.;Li, N.;Nisenbaum, E.;Sun, Q.;Chen, B.;Casiano, R.;Weed, D.;Telischi, F.;Denneny, J. C., 3rd;Liu, X. *; Shu, Y*., Otolaryngology Providers Must Be Alert for Patients with Mild and Asymptomatic COVID-19. Otolaryngol Head Neck Surg 2020, 162 (6), 809-810.
Zhang, K.; Fang, Y.; Wang, B.; Cheng, X.; Chen, B. *; Shu, Y*, Frequency-specific hearing results after stapes surgery for Chinese population otosclerosis with different degrees of hearing loss. Acta Otolaryngol2020, 140 (5), 356-360.
Wenwei Luo, Jingfang Wu, Kevin A. Peng , Qingzhong Li, Qiang Du,Jianghong Xu, Chunfu Dai, Fanglu Chi*, Yilai Shu*，Clinical characteristics of patients with papilloma in the external auditory canal，Laryngoscope，27-Aug-2020， 2020 Oct 8. doi: 10.1002/lary.29113
Yilai Shu#, Lijun Wang#, Xiaoting Cheng, Chayada Tangshewinsirikul, Weili Shi, Yasheng Yuan, Zhiqiang Yang, Huawei Li, Jun Shen*, Bing Chen*, Weiguo Zou* The p.Pro170Leu Variant in NOG Impairs Noggin Secretion and Causes Autosomal Dominant Congenital Conductive Hearing Loss Due to Stapes Ankylosis, Journal of Genetics and Genomics, 2019 Sep 20;46(9):445-449.
Jinghan Wang#, Jun Shen#, Luo Guo, Cheng Cheng, Renjie Chai, Yilai Shu* Huawei Li*. A humanized mouse model demonstrated that apparently autosomal dominant deafness caused by MYO6 p.C442Y is inherited in a semi-dominant pattern. Hearing research, 2019 Aug;379:79-88.
Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR*. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology. 2015 Jan;33(1):73-80.
Xiaoting Cheng#, Yanqing Fang, Yilai Shu*, Duo-Duo Tao, Yangwenyi Liu, Bing Wang, Yasheng Yuan, John J. Galvin, Qian-Jie Fu, Bing Chen* Music training can improve music and speech perception in pediatric Mandarin-speaking cochlear implant users. Trends in Hearing，2018 9:2331216518759214,
Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY*, Liu DR*. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221.
Shu Y#, Tao Y, Wang Z, Tang Y, Li H, Dai P, Gao G, Chen ZY*. Identification of Adeno-associated viral vectors (AAV) that target neonatal and adult mammalian inner ear cell subtypes. Human Gene Therapy. 27(9):687-99.2016 Jun 24. (Cover story)
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