周玉峰 - 复旦大学 - 生物医学研究院

个人简介

工作经历研究员，复旦大学生物医学研究院（2015.6-至今）研究员（双聘PI），复旦大学附属儿科医院（2015.6-至今）兼职助理教授，医学系，美国约翰霍普金斯大学（2015.5-2019.7）讲师，医学系，美国约翰霍普金斯大学（2011.7-2015.5）博士后，医学系，美国约翰霍普金斯大学（2007.12-2011.6）助理研究员，肿瘤和免疫系，美国杜克大学（2006.9-2007.11）医师，深圳市儿童医院（2000.7-2003.7）教育经历博士，儿科学，华中科技大学（2003.9-2006.6）硕士，儿科学，华中科技大学（1997.9-2000.6）学士，临床医学，潍坊医学院（1992.9-1997.7）所获人才项目上海市医学领军人才，上海市卫计委，2019 所获奖项上海市医学科技三等奖，上海市卫生健康委员会，2023 Signal Transduct Target Ther 杂志年度最佳论文奖，2022 中华医学会儿科分会第二届高影响力论文奖，2020 中华医学会呼吸病学分会高影响力论文奖，2020 广东省科技进步二等奖，广东省人民政府，2019 深圳市科技进步二等奖，深圳市人民政府，2019 重庆市科技进步三等奖，重庆市人民政府，2004

研究领域

主要研究环境和表观遗传学因素对免疫系统发育和功能的影响，包括：过敏性疾病、自身免疫性疾病、感染与炎症、肿瘤性疾病的免疫学发病机制和防治研究。研究方向包括：①非编码RNA与免疫调节；②环境和表观遗传学因素对免疫系统发育及功能的影响；③代谢重编程与免疫调节；④肿瘤免疫学；⑤免疫性疾病的细胞与基因治疗。在Nature Medicine，Nature Cell Biology，Nature Communications，Blood，Science Advances，Journal of Allergy and Clinical Immunology，Allergy，Cellular and Molecular Immunology和STTT等杂志发表论文90余篇。

近期论文

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Han X#, Liu L#, Huang S#, Xiao W#, Gao Y#, Zhou W, Zhang C, Zheng H, Yang L, Xie X, Liang Q, Tu Z, Yu H, Fu J, Wang L, Zhang X, Qian L*, Zhou Y*. RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis. Nature Communications 2023; 14:7328. Hu XL#, Xiao W#, Lei Y, Green A, Lee X, Maradana MR, Gao Y, Xie X, Wang R, Chennell G, Basson MA, Kille P, Maret W, Bewick GA, Zhou Y*, Hogstrand C*. Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier. Nature Communications 2023; 14:5431. Wei R#, Han X#, Li M, Ji Y, Zhang L, Christodoulou MI, Hameed Aga NJ, Zhang C, Gao R, Liu J, Fu J, Lu G, Xiao X, Liu X, Yang PC, McInnes IB, Sun Y, Gao P, Qin C*, Huang SK*, Zhou Y*, Xu D*. The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARgamma. Cellular and Molecular Immunology2023.Online ahead of print. Ying J#, Zhang C#, Wang Y, Liu T, Yu Z, Wang K, Chen W, Zhou Y*, Lu G*. Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis. Frontiers in Immunology 2023; 14:1172892. Liu T#, Zhang C#, Ying J, Wang Y, Yan G, Zhou Y*, Lu G*. Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Frontiers in Immunology 2023; 14:1134556. Liang Q#, Fu J#, Wang X, Liu L, Xiao W, Gao Y, Yang L, Yu H, Xie X, Tu Z, Huang S, Han X, Qian L*, Zhou Y*. circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma. Allergy 2023; 78:1459-1472. Liu KY#, Gao Y#, Xiao W#, Fu J#, Huang S, Han X, Hsu SH, Xiao X, Huang SK*, Zhou Y*. Multidimensional analysis of lung lymph nodes in a mouse model of allergic lung inflammation following pm2.5 and indeno[1,2,3-cd]pyrene exposure. Environmental Health Perspectives 2023; 131:37014. Yuan X#., Wang R#., Han B., Sun C., Chen R., Wei H., Chen L., Du H., Li G., Yang Y., Chen X., Cui L., Xu Z., Fu J., Wu J., Gu W., Chen Z., Fang X., Yang H., Su Z., Wu J., Li Q., Zhang M., Zhou Y., Zhang L., Ji G*., Luo F*. Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes. Nature Communications 2022; 13:6356. Yang L#, Fu J#, Han X#, Zhang C#, Xia L, Zhu R, Huang S, Xiao W, Yu H, Gao Y, Liang Q, Li W*, Zhou Y*. Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. Journal of Allergy and Clinical Immunology. 2022 Jun;149(6):2021-2033 Chen LL#, Morcelle C#, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D*.Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.Nature Cell Biology. 2022 Mar;24(3):353-363. Qiu Z., Zhu Z., Liu X., Chen B., Yin H., Gu C., Fang X., Zhu R., Yu T., Mi W., Zhou H., Zhou Y., Yao X*., Li W*. A dysregulated sebum-microbial metabolite-IL-33 axis initiates skin inflammation in atopic dermatitis. Journal of Experimental Medicine 2022; 219(10):e20212397 Xue P#, Huang S#, Han X#, Zhang C, Yang L, Xiao W, Fu J, Li H*, Zhou Y*. Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2.Cell Death and Differentiation. 2022 Jan;29(1):82-95. Yang L, Xie X, Tu Z, Fu J, Xu D*, Zhou Y*. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduction and Targeted Therapy. 2021 Jul 7;6(1):255. doi: 10.1038/s41392-021-00679-0. Xia L#, Wang X#, Liu L#, Fu J#, Xiao W, Liang Q, Han X, Huang S, Sun L, Gao Y, Zhang C, Yang L, Wang L, Qian L*, Zhou Y*. lnc-BAZ2B promotes M2 macrophage activation and inflammation in children with asthma through stabilizing BAZ2B pre-mRNA. Journal of Allergy and Clinical Immunology 2021; 147:921-32 e9. Li H#, Li X#, Zheng H, Liu L, Wu Y, Zhou Y, Meng X, Hong J, Cao L, Lu Y, Dong X, Xia M, Ding B, Qian L, Wang L, Zhou W, Gui Y, Kan H, Chen R*, Zhang X*. Ultrafine particulate air pollution and pediatric emergency-department visits for main respiratory diseases in Shanghai, China. Science of the Total Environment 2021; 775:145777. Zhang C#, Han X#, Yang L#, Fu J#, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, Luo F, Lu W, Zhou Y*. Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. Theranostics 2020; 10:10908-24. Yang L#, Han X#, Zhang C#, Sun C#, Huang S, Xiao W, Gao Y, Liang Q, Luo F, Lu W, Fu J*, Zhou Y*. Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. Frontiers in Immunology 2020; 11:576903. Yang L, Fu J, Zhou Y*. Research Progress in Atopic March. Frontiers in Immunology 2020; 11:1907. Sun L#, Fu J#, Lin SH#, Sun JL#, Xia L, Lin CH, Liu L, Zhang C, Yang L, Xue P, Wang X, Huang S, Han X, Chen HL, Huang MS, Zhang X, Huang SK, Zhou Y*. Particulate matter of 2.5 mum or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1alpha in an asthma model. Journal of Allergy and Clinical Immunology 2020; 145:402-14. Huang S#, Xue P#, Han X#, Zhang C, Yang L, Liu L, Wang X, Li H, Fu J*, Zhou Y*. Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis. Cell Death and Disease 2020; 11:408. Han X#, Huang S#, Xue P#, Fu J#, Liu L, Zhang C, Yang L, Xia L, Sun L, Huang SK, Zhou Y*. LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE. Science Advances 2019; 5:eaax9230. Zhang C, Fu J, Zhou Y*. A Review in Research Progress Concerning m6A Methylation and Immunoregulation. Frontiers in Immunology 2019; 10:922. Yu J#, Luo Y#, Zhu Z#, Zhou Y#, Sun L, Gao J, Sun J, Wang G, Yao X*, Li W*. A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. Journal of Allergy and Clinical Immunology 2019; 143:2108-19 e12. Wang HC, Wong TH, Wang LT, Su HH, Yu HY, Wu AH, Lin YC, Chen HL, Suen JL, Hsu SH, Chen LC, Zhou Y, Huang SK*. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cellular and Molecular Immunology 2019; 16:783-90. Wang E, Liu X, Tu W, Do DC, Yu H, Yang L, Zhou Y, Xu D, Huang SK, Yang P, Ran P, Gao PS*, Liu Z*. Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. Allergy 2019; 74:1675-90. Zhou Y#, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK*, Gao P*. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. Journal of Allergy and Clinical Immunology 2018; 141:350-64 e8. Yang L, Fu J, Zhou Y*. Circular RNAs and Their Emerging Roles in Immune Regulation.Frontiers in Immunology 2018; 9:2977. Xue P, Fu J, Zhou Y*. The Aryl Hydrocarbon Receptor and Tumor Immunity. Frontiers in Immunology 2018; 9:286. Sun L, Fu J, Zhou Y*. Metabolism Controls the Balance of Th17/T-Regulatory Cells. Frontiers in Immunology 2017; 8:1632. Qu J, Do DC, Zhou Y, Luczak E, Mitzner W, Anderson ME, Gao P. Oxidized CaMKII promotes asthma through the activation of mast cells. JCI Insight 2017; 2:e90139. Kawasaki H, Chang HW, Tseng HC, Hsu SC, Yang SJ, Hung CH, Zhou Y, Huang SK*. A tryptophan metabolite, kynurenine, promotes mast cell activation through aryl hydrocarbon receptor. Allergy 2014; 69:445-52. Zhou Y, Tung HY, Tsai YM, Hsu SC, Chang HW, Kawasaki H, Tseng HC, Plunkett B, Gao P, Hung CH, Vonakis BM, Huang SK*. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 2013; 121:3195-204. Zhou Y#, Kawasaki H#, Hsu SC, Lee RT, Yao X, Plunkett B, Fu J, Yang K, Lee YC, Huang SK*. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nature Medicine 2010; 16:1128-33.