个人简介
袁海心，特聘教授，博士生导师。2002年毕业于中国科学技术大学，获理学学士学位；2009年毕业于中国科学院上海生化细胞研究所，获生物化学与分子生物学博士学位；2009-2014年在美国加州大学圣迭戈分校做博士后，从事细胞生长与细胞自噬的调控机制研究。2014年11月受聘于复旦大学生物医学研究院，任青年研究员/PI；2019年12月晋升为研究员/PI。2022年1月加入重庆医科大学生命科学研究院。
袁海心教授关注细胞代谢与死亡调控机制的研究，已发表学术论文近40篇（总影响因子逾500），其中通讯及一作论文22篇。获得国家自然科学基金面上项目（4项）、国家科技重大专项和国家重点研发计划等资金支持，并入选上海高校特聘教授（东方学者）、上海市人才发展资金、重庆市留创计划（重点项目）以及重庆医科大学重大科技人才项目“揭榜挂帅”（A类）等人才计划。
EDUCATION EXPERIENCE
1998-2002 Undergraduate student in the School of Life Sciences, University of Science and Technology of China (USTC), Hefei, China, B.S.
2002-2008 Graduate student in the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China, Ph.D.
(Biochemistry and Molecular Biology, Mentor: Zhengjun Chen, Ph.D.)
WORKING EXPERIENCE
2009/09-2014/08 Postdoctoral fellow in Moores Cancer Center, University of California at San Diego, USA (Mentor: Kun-Liang Guan, Ph.D.)
2014/11-2019/11 Associate Professor, Institutes of Biomedical Sciences, Fudan University
2016/12-2019/12 Associate Professor, Shanghai Fifth People’s Hospital, Fudan University
2019/12-2021/12 Professor, Institutes of Biomedical Sciences, Fudan University
2020/01-2021/12 Principle Investigator, Shanghai Fifth People’s Hospital, Fudan University
2022/01-present Professor, Institute of Life Sciences, Chongqing Medical University
近期论文
查看导师最新文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Liu JP#, Cen SY#, Xue Z, Wang TX, Gao Y, Zheng J, Zhang C, Hu J, Nie S, Xiong Y, Guan KL, Yuan HX*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem Biol. 2022, 17(12):3389-3406.
Sun SJ#, Ai Y#, Duan KL, Zhang JY, Zhang C, Sun YP, Xiong Y, Guan KL, and Yuan HX*. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene 2022, 41:5385-5396.
Wang TX#, Duan KL#, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C*, Guan KL and Yuan HX*. Tanshinone functions as a coenzyme that confers gain-of-function of NQO1 to suppress ferroptosis. Life Sci Alliance 2022, 6:e202201667.
Hu M#, Bao R#, Lin M#, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, and Yuan HX*. ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene 2022, 41:4547-4559.
Liu P#, Sun SJ#, Ai Y#, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M*, and Yuan HX*. Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance. Cell Death Dis. 2022, 13:205. (*co-corresponding)
Bao R, Meng Y, Zhang H, Yang C, Li W, Zhang C, Zhang J, Sun R, Li Z, Jiang W, Zhang C, Zhang C*, Yuan HX*, and Dang Y*. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death Dis. 2021, 12:972. (*co-corresponding)
Liu P#, Liu JP#, Sun SJ#, Gao Y, Ai Y, Chen X, Sun Y, Zhou M, Liu Y, Xiong Y, and Yuan HX. CBFB-MYH11 fusion sequesters RUNX1 in cytoplasm to prevent DNMT3A recruitment to target genes in AML. Front Cell Dev Biol. 2021, 9:675424.
Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J*, and Yuan HX*. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020, 40:1378-1394. (*co-corresponding)
Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, and Yuan HX. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019, 10:755.
Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, and Yuan HX. ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019, 476:2239-2254.
Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, and Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018, 9:508.
Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH*, Yuan HX*, and Xiong Y*. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 2018, 37:1637-1653. (*co-corresponding)
Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, and Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017, 284: 3619-3636.
Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y*, Yuan HX*, and Guan KL*. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Res. 2017, 77: 2413-2423. (*co-corresponding)
Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y*, Yuan HX*, and Guan KL*. Thromboxane A2 Activates YAP/TAZ to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016, 291: 18947-18958. (*co-corresponding)
Yuan HX* and Guan KL*. Structural insights of mTOR complex 1. Cell Res. 2016, 26: 267-268. (*co-corresponding)
Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, and Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Gene Dev. 2015, 29: 2362-2376.
Yuan HX and Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015, 5: 1127-1129.
Yuan HX, Russell RC, and Guan KL. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 2013, 9: 1983-1995.
Yuan HX, Xiong Y, and Guan KL. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013, 49: 379-387.
Yuan H#, Zhang H#, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, and Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2009, 49: 240-249. (#co-first)
Yuan H, Zhang L, Liu A, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang Y, and Chen Z. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J. Proteome Res. 2006, 5: 299-307.
京公网安备 11010802027423号