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Li C, Chi H, Deng S, Xu K, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J(*). THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy. J Immunother Cancer. 2021 Aug;9(8):e002443.
Chushu Li, Han Yao, Huanbin Wang, Jing-Yuan Fang, Jie Xu(*), Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity. Oncogene. 2020. DOI: 10.1038/s41388-020-01592-6
Jie Xu (*), Jean-Philippe Brosseau, and Hubing Shi, Targeted degradation of immune checkpoint proteins: emerging strategies for cancer immunotherapy. Oncogene. 2020; DOI: 10.1038/s41388-020-01491-w
Xu, J (*). (2020). Regulation of Cancer Immune Checkpoints. Springer Nature. Hardcover ISBN: 9811532656. Pages 1-653. (*Book Editor)
Wang, Huanbin(#); Yao, Han; Li, Chushu; Shi, Hubing; Lan, Jiang; Li, Zhaoli; Zhang, Yao; Liang, Lunxi; Fang, Jing-Yuan; Xu, Jie(*), HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity. Nature Chemical Biology, 2019 (1): 42~50. (highly cited)
Han Yao; Jiang Lan; Chushu Li; Hubing Shi; Jean-Philippe Brosseau; Huanbin Wang; Haojie Lu; Caiyun Fang; Yao Zhang; Lunxi Liang; Xiaolin Zhou; Chaojun Wang; Yu Xue; Yun Cui; Jie Xu (*), Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours, Nature Biomedical Engineering, 2019; 3(5):414. (highly cited)
Liang L(#), Wang H(#), Shi H, Li Z, Yao H, Bu Z, Song N, Li C, Xiang D, Zhang Y, Wang J, Hu Y, Xu Q, Ma Y, Cheng Z, Wang Y, Zhao S, Qian J, Chen Y, Fang JY, Xu, J (*), A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity, Cell Chemical Biology, 2018, 25(6): 761~774
Qian J, Li Y, Yao H, Tian H, Wang H, Ai L, Xie Y, Bao Y, Liang L, Hu Y, Zhang Y, Wang J, Li C, Tang J, Chen Y, Xu, J (*), Fang JY(*). ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. Signal Transduction & Targeted Therapy. 2017; 2:17003
Wang, Huanbin(#); Yao, Han(#); Li, Chushu; Liang, Lunxi; Zhang, Yao; Shi, Hubing; Zhou, Chongzhi; Chen, Yingxuan; Fang, Jing-Yuan; Xu, Jie (*), PD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation, Oncoimmunology, 2017, 6(7): e1327494
Zhang, Y.(#); Hu, Y.(#); Wang, J-L; Yao, H.; Wang, H.; Liang, L.; Li, C.; Shi, H.; Chen, Y.; Fang, J-Y; Xu, J.(*), Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp, Oncogene, 2017, 36(39): 5473~5483
Yao, Han(#); Wang, Huanbin; Li, Chushu; Fang, Jing-Yuan; Xu, Jie; Xu, J (*), Cancer Cell-intrinsic PD-1 and implications in Combinatorial immunotherapy, Frontiers in Immunology, 2018, 9(1774): 0~1774. (highly cited)
Xie, Yuan-Hong(#); Gao, Qin-Yan; Zou, Tian-Hui; Chen, Hui-Min; Yu, Si-Yi; Qiu, Yi-Wen; Gu, Wei-Qi; Chen, Xiao-Yu; Cui, Yun; Sun, Danfeng; Xu, Jie; Chen, Ying-Xuan; Fang, Jing-Yuan; Cai, Guo-Xiang; Cai, San-Jun; Sun, Xiao-Ming; Liu, Zhan-Ju; Cai, SJ(*); Xu, J (*); Chen, YX(*); Fang, JY(*), Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies, EBioMedicine, 2017, 25: 32~40
Wang H(#); Liang L; Fang JY; Xu J (*), Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers, Oncogene, 2016, 35(304): 2011~2019. (highly cited)
Liang L(#); Fang JY(*); Xu J (*), Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy, Oncogene, 2016, 35(12): 1475~1482. (highly cited)
Qian, Jin(#); Kong, Xuan(#); Deng, Niantao; Tan, Patrick; Chen, Haoyan; Wang, Jilin; Li, Zhaoli; Hu, Ye; Zou, Weiping; Xu, Jie (*); Fang, Jing-Yuan(*), OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer, Gut, 2015, 64(1): 37~48
Wang, Jilin(#); Qian, Jin(#); Hu, Ye; Kong, Xuan; Chen, Haoyan; Shi, Qinghua; Jiang, Long; Wu, Chenming; Zou, Weiping; Chen, Yingxuan; Xu, Jie (*); Fang, Jing-Yuan(*), ArhGAP30 promotes p53 acetylation and function in colorectal cancer, Nature Communications, 2014, 5: 5735
Hu, Ye(#); Wang, Jilin; Qian, Jin; Kong, Xuan; Tang, Jieting; Wang, Yingchao; Chen, Haoyan; Hong, Jie; Zou, Weiping; Chen, Yingxuan; Xu, Jie (*); Fang, Jing-Yuan(*), Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer, Cancer Research, 2014, 74(23): 6890~6902. (highly cited)
Xuan Kong, Jin Qian, Li-Sha Chen, Ying-Chao Wang, Ji-Lin Wang, Haoyan Chen, Yu-Rong Weng, Shu-Liang Zhao, Jie Hong, Ying-Xuan Chen, Weiping Zou, Jie Xu (*), Jing-Yuan Fang(*), Synbindin in Extracellular Signal-Regulated Protein Kinase Spatial Regulation and Gastric Cancer Aggressiveness, JNCI:Journal of the National Cancer Institute, 2013, 105(22):1738-49
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