刘荣花 - 复旦大学 - 生物医学研究院

个人简介

工作经历青年研究员复旦大学生物医学研究院(2018.2-至今) 博士后复旦大学生物学流动站（医口）(2015.07-2018.1) 教育经历博士复旦大学基础医学院免疫学(2010.09-2015.06) 学士河南师范大学生命科学学院生物科学(2006.09-2010.06) 所获人才项目上海市科技启明星计划（2019）上海市卫计委优秀青年医学人才培养计划（2018）所获奖项上海市自然科学奖二等奖（2020）中国免疫学会青年学者奖（2018）上海免疫学会优秀论文奖（2017）

研究领域

B淋巴细胞与肿瘤免疫调节。免疫系统维持机体内环境稳态，其功能异常涉及肿瘤、炎症和自身免疫等疾病发病和进展。B淋巴细胞主司抗体分泌、介导体液免疫。我们聚焦肿瘤中的B淋巴细胞，拟揭示B细胞功能异常参与肿瘤发生进展的分子基础，寻找肿瘤免疫清除的潜在靶点。已经证实B细胞在肿瘤中的双向功能，发现其效应性向调节性功能的偏移，提出了通过亮氨酸节制饮食控制Breg，阻止肠癌免疫逃逸的饮食干预思路。目前正在解析B细胞调节性功能的获得机制，寻找干预Breg的表观遗传与营养代谢靶点，助力肿瘤免疫治疗。

近期论文

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Wang Z#, Lu Z#, Lin S#, Xia J, Zhong Z, Xie Z, Xing Y, Qie J, Jiao M, Li Y, Wen H, Zhao P, Zhang D, Zhou P, Qian J, Luo F, Wang L, Yu H, Liu J, Gu J, Liu R*, Chu Y*. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Immunity. 2022; 55(6):1067-1081.e8. Lu Z#, Liu R#, Wang Y#, Jiao M#, Li Z, Wang Z, Huang C, Shi G, Ke A, Wang L, Fu Y, Xia J, Wen H, Zhou J, Wang X, Ye D, Fan J*, Chu Y*, Cai J*. Ten-eleven translocation-2 inactivation restrains IL-10-producing regμLatory B cells to enable antitumor immunity in hepatocellμLar carcinoma. Hepatology. 2022; doi: 10.1002/hep.32442. Xia J*, Xie Z*, Niu G, Lu Z, Wang Z, Xing Y, Ren J, Hu Z, Hong R, Cao Z, Han S, Chu Y, Liu R*, Ke C*. Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer. Immunology. 2022; doi: 10.1111/imm.13568. Zhong Z#, Nan K#, Weng M#, Yue Y, Zhou W, Wang Z, Chu Y, Liu R*, Miao C*. Pro- and Anti- Effects of Immunogloblin A- Producing B Cell in Tumors and Its Triggers. Front Immunol. 2021; 12:765044. Gu J#, Mao W#, Ren W#, Xu F, Zhu Q, Lu C, Lin Z, Zhang Z, Chu Y, Liu R*, Ge D*. Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex. Cancer letters. 2019; 443:125-134. Liu J#, Li Y, Lu Z, Gu J, Liang Y, Huang E, Wang Z, Zhang H, Wang L, Zhang D, Liu R*, Chu Y*. Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1. Immunology. 2019; 156(1):56-68. Xu F#, Gu J#, Lu C#, Mao W, Wang L, Zhu Q, Liu Z, Chu Y, Liu R*, Ge D*. Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. International journal of biological sciences. 2019; 15, 127-137. Liu R#, Lu Z#, Gu J#, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y*. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018; 154(3):637-651 Lu Z#, Liu J, Liu X, Huang E, Yang J, Qian J,3, Zhang D, Liu R*, Chu Y*. MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells and Contributes to Immune-mediated Organ Injury.Hepatology. 2017; 67(3):1027-1040 Liu R#, Gu J#, Jiang P, Zheng Y, Liu X, Jiang X, Huang E, Xiong S, Xu F, Liu G, Ge D*, Chu Y*. DNMT1-microRNA126 epigenetic circuit contributes to esophageal squamous cell carcinoma growth via ADAM9-EGFR-AKT signaling. Clin Cancer Res. 2015; 15; 21:854-863.