孙剑 - 天津大学 - 药物科学与技术学院

个人简介

Education Background： Doctoral degree| Academy of Military Medical Sciences, Beijing, Chi| 2006 Positions & Employments： 2002.9- Tianjin University | Associate Professor 1999.9-2002.6 City College, City University of New York (CUNY) | Research associate 1994.9-1999.6 Hunter Colllege, CUNY | Research assistant, 1989.9-1991.6 Capital Institute of Medicine (Beijing, China) | Assistant Professor Honors & Awards： 2015 Tianjin best advisor for PSIP (Project of Student Innovation and Practice)

研究领域

Several peptibodies inhibiting B lymphocyte stimulator (BLyS), a critical factor for B cell maturation and survival, are currently tested in cell culture and SLE animal models in this lab. The strategy in this group is to design cytokine antagonist peptides using computer-aided design, fuse the peptides with human IgG Fc to form peptibodies by gene engineering, and analyze their activity in vitro and in vivo. Because overexpression of BLyS is involved in pathogenesis and development of autoimmune diseases and B cell malignances, the BLyS antagonists designed and analyzed may be potential therapeutic reagents for these diseases. The research in the group of Sun involves investigation of B cell development and B cell related diseases. In recent years, immunotherapies with antibodies to depleting B cells are widely used in autoimmune diseases and B cell lymphoma.

近期论文

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Jiang, Y., Sun, J. & Wei, J. Distinct binding mode of BAFF antagonist antibodies belimumab and tabalumab, analyzed by computer simulation. J Mol Model 28, 292 (2022). https://doi.org/10.1007/s00894-022-05142-7 New therapeutic strategies based on biasing IL-2 mutants for cancers and autoimmune diseases Jin Dongfu,Jiang Yaxin,Chang Lu,Wei Jing,Sun Jian Page:108935 ISSN:1567-5769 2022 Container-title:International Immunopharmacology Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia BioMed Research International 2022-04-15 | Journal article | Author DOI: 10.1155/2022/5504475 Part of ISSN: 2314-6141 Part of ISSN: 2314-6133 CONTRIBUTORS: Xiaolei Song; xiaojing wu; zhang zihan; Cui zhangxiu; Yong Zheng; jian sun Analysis of the molecular mechanism of SARS-CoV-2 antibodies Jin Dongfu,Wei Jing,Sun Jian Page:45-52 ISSN:0006-291X 2021 Container-title:Biochemical and Biophysical Research Communications Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy Zhao Haodi,Wei Jing,Sun Jian Page:107101 ISSN:1567-5769 2020 Container-title:International Immunopharmacology Overview of anti-BCMA CAR-T immunotherapy for multiple myeloma and relapsed/refractory multiple myeloma Deming Feng, Jian Sun First published: 29 May 2020 https://doi.org/10.1111/sji.12910 Study on the Mechanism of Selective Interaction of BR3 and BCMA with BAFF and APRIL Protein & Peptide Letters 2020-11-16 | Journal article DOI: 10.2174/0929866527666200413101757 CONTRIBUTORS: Luoman Li; Yaxin Jiang; LiLi Su; Deming Feng; Jing Wei; Jian Sun Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics Journal of Materials Chemistry B 2019 | Journal article DOI: 10.1039/C8TB03351J CONTRIBUTORS: Yuehua Wang; Zihua Wang; Yixia Qian; Linyang Fan; Chunyan Yue; Fei Jia; Jian Sun; Zhiyuan Hu; Weizhi Wang Boosting the Theranostic Effect of Liposomal Probes toward Prominin-1 through Optimized Dual-Site Targeting Analytical Chemistry 2019-06-04 | Journal article DOI: 10.1021/acs.analchem.9b00622 CONTRIBUTORS: Yuehua Wang; Fei Jia; Zihua Wang; Yixia Qian; Linyang Fan; He Gong; Aiqin Luo; Jian Sun; Zhiyuan Hu; Weizhi Wang Construction of small molecular CTLA4 analogs with CD80-binding affinity Liu Fang,Su LiLi,Chen Ziteng,Feng Deming,Wei Jing,Sun Jian Page:694-700 ISSN:0006-291X 2019 Container-title:Biochemical and Biophysical Research Communications