胡晋川 - 复旦大学 - 生物医学研究院

个人简介

工作经历青年研究员复旦大学，生物医学研究院/上海市第五人民医院，(2018.1-今) 研究助理美国北卡罗莱纳大学教堂山分校，(2017.6-2017.12) 博士后美国北卡罗莱纳大学教堂山分校，(2012.6-2017.5) 教育经历博士中国科学院微生物研究所，(2004-2012) 学士北京大学，生命科学学院，(2000-2004)

研究领域

课题组致力于开发和利用新的高通量测序技术来检测和研究各种DNA碱基损伤与修复，包括紫外线和顺铂等造成的DNA加合物损伤、8-oxo-dG和AP位点等DNA氧化损伤，以及对应的核苷酸切除修复与碱基切除修复途径。课题组长胡晋川在2015年诺贝尔化学奖得主Aziz Sancar教授实验室做博士后期间，主导开发了Damage-seq和XR (eXcision Repair) -seq方法，分别能以单碱基分辨率检测人类基因组上各种DNA加合物损伤和核苷酸切除修复的发生位置。目前，课题组的研究方向主要包括：1）核苷酸切除修复的分子机制，尤其是转录偶联核苷酸切除修复的分子机制；2）染色质环境中氧化损伤形成与修复的规律，及其参与转录调控的机制；在此基础上，还将研究损伤与修复在相关疾病发生发展中的作用。

近期论文

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Yongchang Zhu#, Yuanqing Tan#, Lin Li#, Yuening Xiang, Yanchao Huang, Xiping Zhang, Jiayong Yin, Jie Li, Fei Lan, Maoxiang Qian*, Jinchuan Hu*. Genome-wide mapping of protein–DNA damage interaction by PADD-seq. Nucleic Acids Research, 2023, 51(6): e32. Yanchao Huang#, Cem Azgar#, Mengdie Yin, Yi-Ying Chiou, Laura A. Lindsey-Boltz, Aziz Sancar, Jinchuan Hu*, Ogun Adebali*. Effects of replication domains on genome-wide UV-induced DNA damage and repair. PLoS Genetics, 2022, 18(9): e1010426. Jiao An#, Mengdie Yin#, Jinchuan Hu*. G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome: methodologies and crosstalk. Genome Instability & Disease, 2022, 3: 241–254. Xiping Zhang, Mengdie Yin, Jinchuan Hu*. Nucleotide Excision Repair: A Versatile and Smart Toolkit. Acta Biochimica et Biophysica Sinica, 2022, 54(6): 807-819. Sizhong Wu, Yanchao Huang, Christopher P Selby, Meng Gao, Aziz Sancar*, Jinchuan Hu*. A new technique for genome-wide mapping of nucleotide excision repair without immunopurification of damaged DNA. Journal of Biological Chemistry, 2022, 298(5): 101863. Liudan Jiang#, Jiayong Yin#, Maoxiang Qian#, Shaoqin Rong, Shengqi Zhang, Kejing Chen, Chengchen Zhao, Yuanqing Tan, Jiayin Guo, Hao Chen, Siyun Gao, Tingting Liu, Yi Liu, Bin Shen, Jian Yang, Yong Zhang, Fei-Long Meng, Jinchuan Hu*, Honghui Ma*, Yi-Han Chen*. UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution. Journal of the American Chemical Society, 2022, 144(3): 1323–1331. Jiao An#, Mengdie Yin#, Jiayong Yin#, Sizhong Wu, Christopher P Selby, Yanyan Yang, Aziz Sancar, Guo-Liang Xu, Maoxiang Qian*, Jinchuan Hu*. Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites. Nucleic Acids Research, 2021, 49(21): 12252-12267. Jinchuan Hu#, Wentao Li#*, Ogun Adebali, Yanyan Yang, Onur Oztas, Christopher P. Selby, Aziz Sancar*. Genome-wide mapping of nucleotide excision repair with XR-seq. Nature Protocols, 2019, 14(1): 248-282. Jinchuan Hu, Christopher P Selby, Sheera Adar, Ogun Adebali, Aziz Sancar*. Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans. Journal of Biological Chemistry, 2017, 292(38):15588-15597. Jinchuan Hu#, Ogun Adebali#, Sheera Adar, Aziz Sancar*. Dynamic maps of UV damage formation and repair for the human genome. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(26): 6758-6763. Jinchuan Hu, Sheera Adar*. The cartography of UV-induced DNA damage formation and DNA repair. Photochemistry and Photobiology, 2017, 93 (1): 199-206. Jinchuan Hu, Jason D Lieb, Aziz Sancar*, Sheera Adar*. Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(41): 11507-11512. Sheera Adar#, Jinchuan Hu#, Jason D Lieb*, Aziz Sancar*. Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(15): E2124-E2133. Jinchuan Hu#, Sheera Adar#, Christopher P Selby, Jason D Lieb*, Aziz Sancar*. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes & Development, 2015, 29(9): 948-960. Jinchuan Hu, Jun-Hyuk Choi, Shobhan Gaddameedhi, Michael G Kemp, Joyce T Reardon, Aziz Sancar*. Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo. Journal of Biological Chemistry, 2013, 288(29): 20918–20926. Jinchuan Hu, Li Guo, Kangyun Wu, Bing Liu, Shiwei Lang, Li Huang*. Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus. Nucleic Acids Research, 2012, 40(8): 3470-3483.