何祥火 - 复旦大学 - 生物医学研究院

个人简介

工作经历研究员，复旦大学，生物医学研究院及附属肿瘤医院-肿瘤研究所（2014.01-至今）研究员，上海市肿瘤研究所，癌基因及相关基因国家重点实验室（2008.12-2013.12）副研究员，上海市肿瘤研究所，癌基因及相关基因国家重点实验室（2006.04-2008.11）博士后，美国UT MD安德森癌症中心，分子与细胞肿瘤学系（2003.08-2006.04）助理研究员，上海市肿瘤研究所，免疫室（1998.07-2000.08）教育经历博士，复旦大学，上海医学院（2000-2003）硕士，华东师范大学，生物系（1995-1998）学士，华东师范大学，生物系（1991-1995）所获人才项目中青年科技创新领军人才,科技部,2016 上海市医学领军人才,上海市卫计委,2015 国家杰出青年科学基金,国家自然科学基金,2011 上海市优秀学术带头人,上海市科委,2011 上海市曙光学者,上海市教委,2011 上海市卫计委优秀学科带头人,上海市卫计委,2011 新世纪优秀人才,教育部,2010 浦江人才计划,上海市科委,2006 所获奖项自然科学二等奖（第一完成人），教育部，2012 医学科技奖二等奖（第一完成人），上海市医学会，2011 第五届吴孟超医学科技奖（一等奖），吴孟超医学科技基金会，2011 第十三届银蛇奖（二等奖），上海市卫计委，2011 明治生命科学奖（优秀奖），国家人类基因组南方研究中心，2011

研究领域

研究领域为肿瘤分子生物学，主要从事消化系恶性肿瘤发生与转移的分子机理研究，研究方向包括：1.非编码RNA功能及分子机制；2. RNA可变剪接异常及调控机制；3.转录重编程及表观调控机制。课题组长何祥火主持和参与多项国家和省部级项目，包括科技部重大研究计划、国家自然科学基金重大项目、重大研究计划、重点项目、面上项目、上海市科委重点项目等。迄今为止，已在国内外学术刊物上发表论文120余篇，包括Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Advanced Science, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research等，论文被引11,200余次，H-index为53（至2022-09）（ORCID:0000-0001-8872-668X; Web of Science ResearcherID:I-1497-2014）。

近期论文

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Li H, Song J, He Y, Liu Y, Liu Z, Sun W, Hu W, Lei Q, Hu X, Chen Z*, He X.* CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway. Advanced Science. 2022 Jul;9(21):e2105126. Liang L, Huan L, Wang J, Wu Y, Huang S, He X.* LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation. Cell Discovery.2021 Dec 14;7(1):118. Li Z, Lu X, Liu Y, Zhao J, Ma S, Yin H, Huang S, Zhao Y*, He X.* Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the HDAC6-TRIM28-ZNF354C Corepressor Complex. Hepatology.2021 May; 73(5):1764-1782. Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li C, Lai H, Chen Z, Meng Z, Guo W*, He X.*, Huang S*. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Advanced Science. 2021 May 1;8(13):2001701. Ding J, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y*, He X.*Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma. Hepatology, 2020 Nov;72(5):1666-1681. Hu Z, Dong L, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X.* Splicing Regulator p54nrb/NONO Enhances Carcinogenesis via Oncogenic Isoform Switch of BIN1 in Hepatocellular Carcinoma. Hepatology. 2020 Aug;72(2):548-568. Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang Y*, He X.*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology. 2020 Jan;71(1):259-274. Li S, Hu Z, Zhao Y, Huang S, He X.*Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology. 2019 Jan;69(1):359-375. Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q*, Zhao Y*, He X.*The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun. 2018 Apr 20;9(1):1572. Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y*, He X.* Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway. Hepatology. 2018 Jan;67(1):171-187. Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X,* Huang S*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016 Apr 6;7:11215. Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X.* MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology. 2015 Nov;149(6):1587-1598.e11. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X,* Huang S*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015 Aug;25(8):981-4. Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X.* MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology. 2015 Oct;62(4):1132-44. Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q, Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H*, Dong K*, He X.* Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology. 2014 Nov;60(5):1686-96. Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J*, He XH*, Fan J*. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology. 2014 May; 146(5): 1397-407. Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X.* Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res. 2014 Feb;24(2):204-17. Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X.* Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology. 2013 Aug;58(2):654-66. Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X.* Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology. 2011 Dec;54(6):2064-75. Jia D, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X.* Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology. 2011 Oct; 54(4): 1227-36. Zhao Y, Wang X, Wang T, Hu X, Hui X, Yan M, Gao Q, Chen T, Li J, Yao M, Wan D, Gu J*, Fan J*, He X.* Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology. 2011 Feb;53(2):493-503. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X.* MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology. 2010 Nov; 52(5): 1731-40. Huang S, Wu S, Ding J, Lin J, Wei L, Gu J, He X.* MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Res. 2010 Nov;38(20):7211-8. Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X.* Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol. 2010 Apr;12(4):390-9. Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M, Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X.* MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma. Hepatology. 2010 Mar;51(3):846-56.