陈振国 - 复旦大学 - 生物医学研究院

个人简介

工作经历青年研究员复旦大学生物医学研究院，复旦大学附属上海市第五人民医院兼职教授 (2017.07-今) 助理研究教授美国德克萨斯大学西南医学中心，(2016.05-2017.06) 博士后美国普渡大学，(2010.10-2016.04) 教育经历博士荷兰格罗宁根大学，物理系，(2006-2010) 硕士清华大学，化学系，(2001-2005) 学士同济大学，环境工程系，(1997-2001)

研究领域

课题组利用冷冻电子显微镜结构生物学方法研究病原微生物及相关复合物蛋白质的结构与功能，尤其是新发传染病病毒的全病毒结构，揭示其传染和传播等机制。并深入研究病毒-抗体复合物、病毒-小分子抑制剂复合物、病毒-蛋白药物复合物结构，揭示抗体及药物的中和及作用机制，为病毒疫苗研发和新型药物研发提供重要基础

近期论文

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Wang, Y.; Zhang, X.; Wang, Y.; Ma, Y.; Zhan, W.; Liu, J.; Zhang, M.; Liu, M.; Wang, Q.; Liu, Q.; Sun, T.; Zhu, T.; Wen, Y.; Sun, L*.; Zhao, J *.; Wu, F*.; Chen, Z.*; Huang, J*.; Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies. Cell Discovery 2022, (Accepted)(#Co-first authors, *co-corresponding authors) Zhan, W.; Tian, X.; Zhang, X.; Xing, S.; Song, W.; Liu, Q.; Hao, A.; Hu,Y., Zhang, M.; Ying, T.*;Chen, Z.*; Lan, F.*; Sun, L.*, Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes Omicron variant by disassembling the spike trimer. J Virol 2022, 96(16):e0048022. Li, C.; Zhan, W.; Yang, Z.; Tu, C.; Hu, G.; Zhang, X.; Song, W.; Du, S.; Zhu, Y.; Huang, K.; Kong, Y.; Zhang, M.; Mao, Q.; Gu, X.; Zhang, Y.; Xie, Y.; Deng, Q.; Song, Y.; Chen, Z.; Lu, L.; Jiang, S.; Wu, Y.*; Sun, L.*; Ying, T.*, Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022,185 (8), 1389-1401 e18. Wang, Y.; Zhan, W.; Liu J.; Wang, Y.; Zhang, X.; Zhang, M.; Han, L.; Ma, Y.; Lu, L.; Wen, Y.; Chen, Z.; Zhao, J. *; Wu, F. *; Sun, L. * and Huang, J. *, A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Research 2022, 32: 862–865. Liu, Z#. Xu, W#. Chen, Z#. Fu, W#. Zhan, W#. Gao, Y#. Zhou, J#. Zhou, Y. Wu, J. Wang, Q. Zhang, X. Hao, A. Wu, W. Zhang, Q. Li, Y. Fan, K. Chen, R. Jiang, Q. Mayer, C. Schoofs, T. Xie, Y. Jiang, S. Wen, Y. Yuan, Z*. Wang, K*. Lu, L*. Sun, L*. Wang, Q*. An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein & Cell 2022, 13(9): 655–675. Wang, W#. Wang, Z#. Yang, X#. Gao, Y#. Zhang, X#. Wang, W. Zhao, L. Zhang, J. Jing, Q. Xu, Q. Cao, L. Tian, Y. Sun, J. Sun, L. Jiang, L*. Chen, Z*. Wang, L*. The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discovery 2021, 7(1):94. Chen, Z*. Sun, L*. Zhang, Z*. Fokine, A. Padilla-Sanchez, V. Hanein, D. Jiang, W. Rossmann, M. and Rao, V. Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses. Proc Natl Acad Sci USA 2017. 114(39):E8184–E8193. Sirohi, D*. Chen, Z*. Sun, L. Klose, T. Rossmann, M. Kuhn, R. 3.8 Å Cryo-EM structure of Zika Virus. Science 2016.352(6284):467-470. Liu, Y. Hill, MG. Klose, T. Chen, Z. Watters, K. Bochkov, YA. Jiang, W. Palmenberg, AC. Rossmann, MG. Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.Proc Natl Acad Sci USA 2016. 113(32):8997-9002. Sun, L*. Zhang, X*. Gao, S*. Rao, P. Padilla-Sanchez, V. Chen, Z. Sun, S. Xiang, Y. Subramaniam, S. Rao, V. Rossmann, M. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nature Communications 2015. 6, 7548.