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个人简介

工作经历 双聘研究员,复旦大学附属华山医院,神经外科(2016.6-今) 研究员,复旦大学,生物医学研究院(2012.12-今) 副研究员,复旦大学,生物医学研究院(2009.1-2012.11) 博士后,香港科技大学,生物化学系(2008.2-2008.12) 教育经历 博士,香港科技大学,生物化学系(2003.9-2008.1) 学士,复旦大学,化学系(1999.9-2003.7) 所获人才项目 国家优秀青年科学基金,国家自然科学基金,2014 新世纪优秀人才,教育部,2012 青年拔尖人才,上海市委组织部,2016 曙光学者,上海市教委,2014 青年科技启明星,上海市科委,2010

研究领域

聚焦细胞极化与神经干细胞分化发育中的关键科学问题,在Cell、Nat Cell Biol、Mol Cell、EMBO J、Nat Commun等国际专业期刊发表SCI论文50篇。近期的主要发现为:1)神经干细胞不对称分裂与调控:系统阐明了不对称分裂关键蛋白质机器的模块组装机制,发现蛋白相分离驱动保守的Par3复合物和细胞命运决定因子极性分布,而Par3相分离凝聚体被顶部子细胞继承后通过偶联Notch通路以实现干性传送,率先提出了相分离调控细胞极化的新概念;2)蛋白质稳态维系:系统阐明了Nedd4家族泛素连接酶的活性调控机理,探讨了其活性失调导致的蛋白异常分布对新生神经元迁移的影响,进而发现Nedd4家族的长链泛素化活性受到其相分离能力的调节,为理解蛋白稳态的精细调控提供了新的切入点。曾主持国家重大科学研究计划课题1项、国家重点研发计划课题1项、国家自然科学基金项目6项。现任中国生物物理学会理事,中国细胞生物学会细胞结构与细胞行为专业分会副会长。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Li J, Zhu K, Gu A, Zhang Y, Hu R, Hu W, Lei Q-Y, Wen W*. (2023) Feedback regulation of ubiquitination and phase separation of HECT E3 ligases. Proceedings of the National Academy of Sciences of the United States of America 120, e2302478120. Xu J, Deng X, Gu A, Cai Y, Huang Y, Zhang W, Wen W*, Yunli Xie*. (2023) Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. Cell Reports 42, 112677. Li D, Huang S, Chai Y, Zhao R, Gong J, Zhang QC, Ou G*, Wen W*. (2023)A Paternal Protein Facilitates Sperm RNA Delivery to Regulate Zygotic Development. Science China-Life Sciences 66, 2342-2353. Mayr C*, Mittag T*, Tang T-YD*, Wen W*, Zhang H*, Zhang H*. (2023) Frontiers in biomolecular condensate research. Nature Cell Biology 25, 512-514. (Invited viewpoint) Zhang H*, Ji X*, Li P*, Liu C*, Lou J*, Wang Z, Wen W*, Xiao Y, Zhang M*, Zhu X*. (2020) Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Science China-Life Sciences63, 953-985. (Invited review) Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*. (2020) Par complex cluster formation mediated by phase separation. Nature Communications11, 2266. Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W*. (2019) A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.Nature Communications10, 3162. Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, Long J, Zhang M, Cai Y*, Wen W*.(2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nature Communications9, 737. Yao W, Shan Z, Gu A, Fu M, Shi Z, Wen W*. (2018) WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex. Journal of Biological Chemistry293, 16697-16708. Chen X, Liu Z, Shan Z, Yao W, Gu A, Wen W*.(2018) Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/α-adaptin complex. Journal of Biological Chemistry293, 4149-4158. Zhu K, Shan Z, Chen X, Cai Y, Cui L, Yao W, Wang Z, Shi P, Tian C, Lou J, Xie Y, Wen W*. (2017) Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO Report18, 1618-1630. Zhu K, Shan Z, Zhang L, Wen, W*. (2016) Phospho-Pon binding mediated fine-tuning of Plk1 activity.Structure24, 1110-1119. Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y*, Wen W*, Wang W*. (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nature Communications6, 8381. Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W*, Wen W*. (2013) Structural and biochemical characterization of the interaction between LGN and Frmpd1. Journal of Molecular Biology425, 1039-1049. Zhu J, Shang Y, Xia C, Wang W, Wen W*, Zhang M*. (2011) Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules EMBO Journal30, 4986-4997. Liu W#, Wen W#, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M*. (2011) The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell145, 1088-1101. (#: co-first authors) (Cover article) Zhu J#, Wen W#, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W*, Zhang M*. (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Molecular Cell43, 418-431. (#: co-first authors) Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Ong YS, Hoai TTT, Hong W, Zhang M*. (2010) Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6. Molecular Cell37, 383-395.

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