俞瑾 - 复旦大学 - 基础医学院

个人简介

1997年本科毕业于上海医科大学药理专业，2005年获复旦大学上海医学院中西医结合基础硕士学位，2011年获复旦大学中西医结合基础博士学位。1997年留校工作，历任助教（1997-）、讲师（2002-），副教授（2009-），教授（2022-），其中，2006年6月-2007年9月在美国New York Blood Center / Lindsey F. Kimball Institute做访问学者，2014年破格担任博士生导师。

研究领域

抑郁症及针刺抗抑郁的神经生物学机制研究工作聚焦于1）抑郁症的神经环路机制；2）小胶质细胞-神经元-星形胶质细胞Crosstalk在应激致抑郁中的作用；3）针刺改善抑郁的神经炎症机制；4）新型抗抑郁药和抑郁症非药物疗法的研发；5）用于神经调控的无线光遗传学器件的研发等。先后主持国家自然科学基金面上项目4项，担任1项国家重点研发项目子课题的复旦负责人。在Blood, Psychol Sci, J Neuroinflamm, Brit J Pharmacol, Antioxidants, Neurobiol Dis等SCI期刊发表第一或通讯作者论文20余篇，总被引千余次。

近期论文

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Chen LQ, Lv XJ, Guo QH, Lv SS, Lv N, Xu WD, Yu J*, Zhang YQ*. Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. Br J Pharmacol. 2023 Apr;180(8):1090-1113. Yang L, Shi LJ, Shen SY, Yang JY, Lv SS, Wang ZC, Huang Q, Xu WD, Yu J*, Zhang YQ*. Toward Antifragility: Social Defeat Stress Enhances Learning and Memory in Young Mice Via Hippocampal Synaptosome Associated Protein 25. Psychol Sci. 2023 Apr 11:9567976231160098. Zhang JR, Yin SY, Shen ZQ, Li B, Zhang YQ, Yu J*. Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome. Brain Res Bull. 2023 Apr;195:130-140. Han QQ*, Shen SY, Chen XR*, Pilot A, Liang LF, Zhang JR, Li WH, Fu Y, Le JM, Chen PQ, Yu J*. Minocycline alleviates abnormal microglial phagocytosis of synapses in a mouse model of depression. Neuropharmacology. 2022 Dec 1;220:109249. Li HY, Wang J, Liang LF, Shen SY, Li W, Chen XR, Li B, Zhang YQ*, Yu J*. Sirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol. Antioxidants (Basel). 2022 Sep 23;11(10):1886. Shen SY, Yu R, Li W, Liang LF, Han QQ, Huang HJ, Li B, Xu SF, Wu GC, Zhang YQ*, Yu J*. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice. Neurobiol Dis. 2022 Jul; 169:105743. Wang J, Li HY, Shen SY, Zhang JR, Liang LF, Huang HJ, Li B, Wu GC, Zhang YQ*, Yu J*. The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats. J Steroid Biochem Mol Biol. 2021 Mar;207:105807. Han QQ, Huang HJ, Wang YL, Yang L, Pilot A, Zhu XC, Yu R, Wang J, Chen XR, Liu Q, Li B, Wu GC, Yu J*. Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:11-20. Huang HJ, Chen XR, Han QQ, Wang J, Pilot A, Yu R, Liu Q, Li B, Wu GC, Wang YQ, Yu J*. The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice. Neuropharmacology. 2019 Sep 1;155:31-43. Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL*, Yu J*. G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. Behav Brain Res. 2019 Feb 1;359: 845-852. Wang YL, Han QQ, Gong WQ, Pan DH, Wang LZ, Hu W, Yang M, Li B,Yu J*, Liu Q*. Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats. J Neuroinflammation. 2018 Jan 17;15(1):21. Yue N, Li B, Yang L, Han QQ, Huang HJ, Wang YL, Wang J, Yu R, Wu GC, Liu Q*, Yu J*. Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression. Front Mol Neurosci. 2018 May 31;11:149. Huang HJ, Zhu XC, Han QQ, Wang YL, Yue N, Wang J, Yu R, Li B, Wu GC, Liu Q*, Yu J*. Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents. Behav Brain Res. 2017 May 30;326:33-43. Han QQ, Yang L, Huang HJ, Wang YL, Yu R, Wang J, Pilot A, Wu GC, Liu Q, Yu J*. Differential GR Expression and Translocation in the Hippocampus Mediates Susceptibility vs. Resilience to Chronic Social Defeat Stress. Front Neurosci. 2017 May 23;11:287. Yue N, Huang H, Zhu X, Han Q, Wang Y, Li B, Liu Q, Wu G, Zhang Y*, Yu J*. Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation. 2017 May 10;14(1):102. 英文专著(参编一章) Yu, J*, Li, W. Beneficial Effect of Acupuncture on Depressive Disorders. In: Xia, Y. (eds) Advanced Acupuncture Research: From Bench to Bedside. Springer, Cham (2022).