高清志 - 天津大学 - 药物科学与技术学院

个人简介

Education Experience： 1994 Ph. D. Nagoya University, JP 1994-1999 Postdoctoral Stanford University, USA Professional Experience： 1994-2001 Research Scientist Tokyo, JAPAN 1999-2000 Postdoctoral fellow Stanford University, California, USA 2001-2009 Senior Research Scientist XenoPort, Inc. California, USA 2009-今 Professor Tianjin University, Tianjin, CHINA 2010-今 Director Tianjin Key Laboratory

研究领域

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

近期论文

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Synthesis and Biological Profiling of Novel Strigolactone Derivatives for Arabidopsis Growth and Development Journal of Agricultural and Food Chemistry 2023-08-30 | Journal article DOI: 10.1021/acs.jafc.3c02135 CONTRIBUTORS: Zhaoyong Kang; Yujie Yan; Ruirui Lu; Xiaoqi Dong; Jun Xu; Dong Zheng; Suhua Li; Qingzhi Gao; Shengnan Liu Sunitinib-based Proteolysis Targeting Chimeras (PROTACs) reduced the protein levels of FLT-3 and c-KIT in leukemia cell lines Zhai Jiadai,Li Chuang,Sun Bingxia,Wang Sinan,Cui Yuting,Gao Qingzhi,Sang Feng Page:129041 ISSN:0960-894X 2022 Container-title:Bioorganic & Medicinal Chemistry Letters Proteolysis Targeting Chimeras (PROTACs) Based on Promiscuous Kinase Inhibitor Synergistically Induce Cancer Cell Apoptosis Through Multiple Mechanisms ChemistrySelect 2022-10-26 | Journal article DOI: 10.1002/slct.202203463 CONTRIBUTORS: Jiadai Zhai; Chuang Li; Sinan Wang; Bingxia Sun; Yuting Cui; Qingzhi Gao; Feng Sang An Unrevealed Molecular Function of Corannulene Buckybowl Glycoconjugates in Selective Tumor Annihilation by Targeting the Cancer-Specific Warburg Effect Shengnan Liu, Ziru Sun, Min Liang, Weijie Song, Ru Zhang, Yunli Shi, Yujun Cui,* and Qingzhi Gao* Page:2105315 ISSN:2198-3844 2021 Container-title:Advanced Science DOI: 10.1002/advs.202105315 Progress on COVID-19 chemotherapeutics Zhang Ru,Sun Ziru,Liu Shengnan,Gao Qingzhi ISSN:0023-074X Container-title:Chinese Science Bulletin 2021 抗肿瘤缺氧诱导因子-1的小分子抑制剂 Development of Hypoxia Inducible Factor-1 Small Molecule Inhibitors as Antitumor Agents 王欣瑜, 赵富平, 张儒, 孙子茹, 刘胜男, 高清志化学进展2021, Vol. 33Issue (12): 2259-2269DOI: 10.7536/PC201141 Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery Chemical Communications 2021 | Journal article DOI: 10.1039/D1CC04169J CONTRIBUTORS: Yang Li; Shengnan Liu; Min Liang; Yujun Cui; Hongxia Zhao; Qingzhi Gao A GLUT1 inhibitor-based fluorogenic probe for Warburg effect-targeted drug screening and diagnostic imaging of hyperglycolytic cancers Analytica Chimica Acta 2021-07 | Journal article DOI: 10.1016/j.aca.2021.338593 CONTRIBUTORS: Shunjie Zhang; Xinyu Wang; Ru Zhang; Yujun Cui; Heming Zhang; Weijie Song; Xiaohan Hou; Shibo Fu; Qingzhi Gao; Shengnan Liu 小分子荧光探针在绿色农药开发中的应用 Application of Small-Molecule Fluorescent Probes in the Development of Green Pesticides 侯晓涵, 刘胜男, 高清志化学进展2021, Vol. 33Issue (6): 1035-1043DOI: 10.7536/PC200659 A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging Liu Shengnan,Song Weijie,Cui Yujun,Sun Ziru,Huang Zhenhua,Gao Qingzhi ISSN:1359-7345 Container-title:Chemical Communications 2021