包建民 - 天津大学 - 药物科学与技术学院

研究领域

（1）高效微管电泳技术：随着将毛细管技术拓宽到微管级，毛细电泳技术的应用范围大大地提高了。在这一全新的平台上将可以作很多新课题的研究工作。（2）新型中药筛选平台: 建立一个以微芯片为基础, 以高效微管电泳技术为核心的中药筛选平台的。（3）新型高效分离技术的开发及其在药物研发中的应用：研究和开发各种以电泳和色谱为基础的新型技术。其目的是提高效率，增加产出，和减少劳动强度。

近期论文

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Bao, J., Silicone elastomers and their applications in medicine, the Collection of Graduate Student Papers, Shandong University, 1985,1: 122. Towns, J. K., Bao, J. and Regnier, F. E., Synthesis and evaluation of epoxy polymer phases for the analysis of proteins by capillary zone electrophoresis, J. Chromatogr. A, 1992, 599: 227-237. Bao, J. and Regnier, F. E., Ultramicro enzyme assays in a capillary electrophoretic system, J. Chromatogr. A, 1992, 608: 217-224. Bao, J., Homogeneous enzyme assays in capillary eletrophoresis, Ph.D. thesis, Purdue University, 1993, 234 pp. Univ. Microfilm Int., Order No. DA9513154, AN 1995: 738613. Miller, K., Leesong, I., Bao, J., Regnier, F. E. and Lytle, F. E., Electrophoretically mediated microanalysis of leucine aminopeptidase in complex matrices using time-resolved laser-induced fluorescence detection, Anal. Chem., 1993, 65: 3267-3270. Corey, A.*, Agnew, J., Bao, J., Bryson, P., Comer, P., Griffth, S., and Li, J. Effect of age and gender on azimilide pharmacokinetics after a single oral dose of azimilide dihydrochloride, J. Clin. Pharmacol., 1997, 37: 946-953. Bao, J.*, J. Fijima, and N. Danielson, Determination of minute enzymatic activities by means of capillary electrophoretic techniques, J. Chromatogr. B, 1997, 699: 481-497. Bao, J., Capillary electrophoretic immunoassays, J. Chromatogr. B, 1997, 699: 463-480. Bao, J.*, Parekh, N. and Shuja, A., Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis, J. Chromatogr. B., 1998, 720: 129-140. Bao, J., Separation of proteins by capillary electrophoresis using an epoxy based hydrophilic coating, J. Liq. Chromatogr. Relat. Technol., 2000, 23: 61-78. Danielson, N. D., Gallagher, P. A. and Bao, J. J.*, Chemical reagents and derivatization procedures in drug analysis, Encyclopedia of Anal. Chem., 2000, 7042-7076. Bao, J. J.* and Liu, Y. D., New multi-dimensional electrophoretic separation systems for genome and proteome studies,Frontiers of Biotechnology and Pharmaceuticals, 2000, 1: 1-13. Bao, J. J., Recent Development in the fabrication and applications of polymer microchips, Frontiers of Biotechnology and Pharmaceuticals, 2000,. Bao, J., Silica capillaries: epoxy coating, Encyclopedia of Chromatography, 2001, 4 (259): 774-776. Starkey, D. E., Han, A, Bao, J.J., Ahn, C. H., Wehmeyer, K.R.*, Prenger, M.C., Halsall, H.B., and Heineman, W.R., Fluorogenic assay for beta-glucuronidase using microchip-based capillary electrophoresis, J. Chromatogr. B., 2001, 762: 33-41. Dai, H. J., Parker, C. N., and Bao, J. J.*, Characterization and inhibition study of MurA enzyme by capillary electrophoresis, J. Chromatogr. B 2001,776: 123-132. Bao, J., Validation and application of a HPLC method for the quantitative analysis of azimilide and its metabolite in mouse blood, Frontiers of Biotechnology and Pharmaceuticals, 2002, 3. Dai, J., Tu, J., Anderson, L. N., Wehmeyer, K. R.*, Bao, J. J., and Liu, C. S., and Quay, B.,High-Throughput Separations: Using Multiplexed Capillary Electrophoresis with Laser-Induced Fluorescence Detection, a) LC*GC North America, 2002,20 (7), 606-617. b) Pharma Genomics, 2002, 26-57. Tu, J, Anderson, L. N, Dai, J., Peters, K., Carr, A., Loos, P., Buchanan, D., Bao, J. J., Liu, C. and Wehmeyer, K. R.*, Application of Multiplexed Capillary Electrophoresis with Laser Induced Fluorescence (MCE/LIF) Detection for the Rapid Measurement of Endogenous Extracellular Signal-Regulated Protein Kinase (ERK) Levels in Cell Extracts, J. Chromatogr. B., 2003, 789: 323-335. Starkey, D. E., Abdelaziez, Y., Ahn, C. H., Tu, J., Anderson, L., Wehmeyer, K.R.*, Izzo, N. J., Carr, A. N., Peters, K. G, Bao, J.J., Halsall, H.B., and Heineman, W.R., Determination of endogenous extracellular signal-regulated protein kinase by microchip capillary electrophoresis, Anal. Biochem., 2003, 316: 181-191. Bao, J.*, Villena, J., Wlasichuck, K. and Schmidt, D., High throughput determination of log d values by lc/ms method, in Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications, Analysis and purification methods in combinatorial chemistry, 2003, 435-455. Wu, J., Guo, Y. and Bao*, J., Applications of Electrospray in the Preparation of Nanomaterials, Bulletin of Materials, Special Volume for Nano and New Material, 2005, 19( 4): 8-11. Ding*, G., Tang, A. , Wang, J., Cong, R.., Bao, J., Direct Enantioseparation of Pantoprazole Sodium by High Performance Liquid Chromatography (HPLC) on Teicoplanin-bonded Chiral Stationary Phase, Chinese J. of Chromatogr., 2006, 24 (1):46-48. Ding*, G., Tang, A. , Wang, J., Cong, R.., Bao, J., Preparation of Teicoplanin-bonded Chiral Stationary Phase and its Application on Enantioseparation in Reversed Chromatography, Chinese Anal. Chem.，2006,34(3) 338-342. Y. Liu，G. Ding，J. Wu and J. Bao, New Flash Chromatography, Analytical Instruments, 2006.1, 12-15.