个人简介
教学方面：研究生《现代组织化学》、《分子病理学》、《基础科研病理学》课程负责人，病理系及学院多项本科生课程教学；指导多名本科生科创及毕业课题；担任临床八年制，基础医学医学素养培训导师。主编本研通用教材《实用病理学技术及特殊染色方法》、《现代组织化学原理及技术》；参编系《病理学》教材。
科研方面：主持国家自然基金面上项目3项，上海市自然基金1项；参加了973重大项目，国家自然基金重点项目，上海市重点项目等。
主要研究方向为肿瘤分子病理，先后发表30余篇科研论文，以第一作者或通讯作者发表SCI论文15篇，包括 Nature communications, JCI, JNEN, Cancer Cell, Oncogene, J Neuro-oncology, Acta Neuropathologica等。
近期论文
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Li Z, Gu Z, Wang L, Guan Y, Lyu Y, Zhang J, Wang Y, Wang X, Xiong J, Liu Y*. Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway. Int J Mol Sci. 2023 May 27;24(11):9
Lan Wang, Bei Mao, Keyang Fan, Renqiang Sun, Jialong Zhang, Huazheng Liang, Ying Liu*. ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells. Fluids Barriers CNS. 2022 Sep 8;19(1):73.
Guan Y, Li J, Gong X, Zhu H, Li C, Mei G, Liu X, Pan L, Dai J, Wang Y, Wang E, Liu Y*, Wang X*. Safety and Efficacy of Hypofractionated Stereotactic Radiotherapy with Anlotinib Targeted Therapy for Glioblastoma at the First Recurrence: A Preliminary Report. Brain Sci. 2022 Apr 2;12(4):471. doi: 10.3390/brainsci12040471.
Yang X, Shen X, Li Z, Li W, Liu Y*. Reduction in immune cell number and loss of 5hmC are associated with lesion grade in cervical carcinogenesis. 3 Biotech. 2021 Nov;11(11):486. doi: 10.1007/s13205-021-03028-8.
Wang Z, Yuan Y, Ji X, Xiao X, Li Z, Yi X, Zhu Y, Guo T, Wang Y, Chen L, Liu Y*. The Hippo-TAZ axis mediates vascular endothelial growth factor C in glioblastoma-derived exosomes to promote angiogenesis. Cancer Lett. 2021; 513:1-13. doi: 10.1016/j.canlet.2021.05.002
Chenyue Xu, Luning Mao, Ji Xiong, Jianbo Wen, Yin Wang, Daoying Geng, Ying Liu*. TAZ Expression on Endothelial Cells Is Closely Related to Blood Vascular Density and VEGFR2 Expression in Astrocytomas. J Neuropathol Exp Neurol,2019 Feb 1;78(2):172-180
Xu YP(co-first author), Lv L(co-first author), Liu Y(co-first author), Smith MD, Li WC, Tan XM, Cheng M, Li Z, Bovino M, Aubé J, Xiong Y.Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. J Clin Invest. 2019 Jul 16;130. pii: 129317. doi: 10.1172/JCI129317.
Yuan Liu(co-first author), Ji-Zheng Guo(co-first author), Ying Liu(co-first author), Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu , Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu , Wei Gao , Li Zhou, Yi-Ping Wang , Weiguo Hu, Yuquan Wei, Canhua Huang, Qun-Ying Lei. Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. Nat Commun. 2018;9:4429.
Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A. Sadiq. Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine-induced blood brain barrier dysfunction via suppression of MLCK signaling pathway. Immun Inflamm Dis. 2018 Mar;6(1):72-80. doi: 10.1002/iid3.187.
Hui Yang (co-first author), Ying Liu(co-first author), Feng Bai, Jing-Ye Zhang, Sheng-Hong Ma, Jing Liu,Zu-De Xu, Hong-Guang Zhu, Zhi-Qiang Ling, Dan Ye, Kun-Liang Guan, Yue Xiong. Tumor development is associated with de crease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene, 2013,32,663-669.
6.Liu Y, Jiang W, Liu J, Zhao S, Xiong J, Mao Y, Wang Y. IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma. J Neurooncol. 2012 Sep;109(2):253-60.
Jia Z, Geng D, Xie T, Zhang J, Liu Y(corresponding author). Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci 2012;19(6):820-823.
Ke Rong-Hu, Xiong Ji, Liu Ying *(corresponding author). Adenosine A2a receptor induces GDNF expression by Stat3 signal in vitro. Neuroreport. 2012 Nov 14;23(16):958-62.
Wei Xu(co-first author), Hui Yang(co-first author),Ying Liu (co-first author),Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan, Shi-min Zhao, Yue Xiong. Oncometabolite 2-Hydroxyglutarate is a Competitive Inhibitorof a-Ketoglutarate-Dependent Dioxygenases. Cancer Cell. 2011,19: 17–30.
Ying Liu, Maya Mimuro, Mari Yoshida, Yoshio Hashizume, Hisayoshi Niwa, Shinichi Miyao, Nobuko Ujihira，Hiroyasu Akatsu. Inclusion-positive cell types in adult-onset intranuclear inclusion body disease: implications for clinical diagnosis. Acta Neuropathologica, 2008; 116: 615-623.
专著
刘颖, 刘秀萍主编. 实用病理学技术及特染方法. 第一版,上海,复旦大学出版社,2022年.
刘颖，朱虹光。现代组织化学原理及技术。 第三版，上海，复旦大学出版社，2017年。
张志刚，刘颖。病理学实验教程。第一版，复旦大学出版社，2012年。
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