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个人简介

教育经历 1998/09-2003/06:复旦大学公共卫生学院,预防医学系,学士 2004/09-2009/06:复旦大学基础医学院,病理学系,博士 工作经历 2009/07-2011/03:复旦大学基础医学院,病理学系,讲师 2011/04-2015/11:复旦大学基础医学院,病理学系,副教授 2015/12-2021/07:复旦大学基础医学院,病理学系,教授 2021/08-至今:复旦大学药学院,药理学系,教授 承担科研项目情况 2014.1.1-2017.12.31国家自然科学基金面上项目:“CD70+亚群在乳腺癌肿瘤侵袭转移过程中作用机制研究”,75万元 2016.1.1-2019.12.31国家自然科学基金面上项目:“赖氨酸代谢介导TrkB+亚群参与三阴性乳腺癌复发转移的机制研究”,57万元 2019.1.1-2022.12.31 国家自然科学基金面上项目:“m6A修饰介导CDCP1+亚群参与Kras突变型大肠癌复发转移的机制研究”,63万元 获奖及荣誉 2019年中组部青年拔尖人才 2019年上海市优秀学术带头人 2019年复旦大学“卓越2025”人才培育计划 2015年上海市青年科技启明星 2013年上海市自然科学三等奖(第一完成人) 2014年河南省科技进步二等奖(第三完成人) 2016年全军科学技术进步二等奖(第三完成人)

研究领域

肿瘤代谢异质性 肿瘤多药耐药与侵袭转移

近期论文

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Gao W, Xu Y, Chen T, Du Z, Liu X, Hu Z, Wei D, Gao C, Zhang W, Li Q(*). Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas.PLoS Biol, 2019; 17(8): e3000425. Gao Y, Chen L, Du Z, Gao W, Wu Z, Liu X, Huang H, Xu D, Li Q(*). Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer.Cancer Res, 2019; 79(18): 4638-4649. Du Z, Liu X, Chen T, Gao W,Wu Z, Hu Z, Wei D, Gao C, Li Q(*). Targeting Sirt5-positive subpopulation overcomes multidrug resistance in wild-type Kras colorectal carcinomas. Cell Reports, 2018;22:2677-2689. Wu Z, Wei D, Gao W, Xu Y, Hu Z, Ma Z, Gao C, Zhu X, Li Q(*). TPO-induced metabolic reprogramming drives liver metastasis of colorectal cancer CD110+ tumor-initiating cells. Cell Stem Cell, 2015; 17: 47-59. Yin B, Ma ZY, Zhou ZW, Gao WC, Du ZG, Zhao ZH and Li QQ(*). The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model. Oncogene, 2015; 34: 761-770. Gao W, Chen L, Ma Z, Du Z, Zhao Z, Hu Z, Li Q(*). Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology, 2013; 145: 636-646. Zhuang D, Liu Y, Mao Y, Gao L, Zhang H, Luan S, Huang F, Li Q(*). TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.Int J Cancer, 2012; 130: 309-318. Xu JD, Cao XX, Long ZW, Liu XP, Furuya T, Xu JW, Liu XL, De Xu Z, Sasaki K, Li QQ(*). BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells.J Pathol, 2011; 223: 400-409. Li QQ, Sun YP, Ruan CP, Xu XY, Ge JH, He J, Xu ZD, Wang Q, Gao WC. Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival.Cancer Sci, 2011; 102: 400-406. Li QQ, Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, Wang WJ, Chen Q, Tang F, Liu XP, Xu ZD. Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death & Differ, 2011; 18: 16-25. Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, Tang F, Chen ZQ, Liu XP, Xu ZD. Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells.Clinical Cancer Res, 2009; 15: 2657-2665. Li QQ, Cao XX, Xu JD, Chen Q, Wang WJ, Tang F, Chen ZQ, Liu XP, Xu ZD. The role of P-glycoprotein/cellular prion protein interaction in multidrug-resistant breast cancer cells treated with paclitaxel. Cell Mol Life Sci, 2009; 66: 504-515.

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