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个人简介

教育经历 1998年9月-2001年7月医学博士,流行病学专业,复旦大学公共卫生学院 1995年9月-1998年7月医学硕士,流行病学专业,上海医科大学公共卫生学院 1987年9月-1992年7月医学学士,预防医学专业,安徽医科大学 工作经历 2021年10月-研究员,上海市重大传染病与生物安全研究院 2014年6月-副主任,治疗性疫苗国家工程实验室 2007年9月- 研究员,博士生导师,生物医学研究院&上海医学院,复旦大学 2003年8月-2007年8月副研究员,国际疫苗研究所(联合国UNDP) 2001年9月-2003年7月博士后,教育部医学分子病毒学实验室,复旦大学 1992年9月-1995年8月医师,结防科科员、科长,芜湖市结核病防治所 获得奖项 2001年国家科技进步二等奖,排名第二 2011年教育部自然一等奖,排名第六

研究领域

重要传染病及致瘤病毒相关的疫苗学研究 感染与免疫研究 治疗性疫苗等新型免疫治疗方法的临床研究

近期论文

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Wu D, Ye Y, Tang L, Wang AB, Zhang R, Qian ZH, Wang FZ, Zheng H, Huang C, Lv XY, Wang HF, Zhang YY, Pan JJ, Li YF, Lu MX, Wang CS, Ma YT, An ZJ, Rodewald LE, Yin ZD, Wang XY*, Wu ZY, Shao YM. A Case-Case Study on the Effect of Primary and Booster immunization with China-produced COVID-19 Vaccines on Prevention of Pneumonia and Viral Load among Vaccinated Persons infected by Delta and Omicron Variants. Emerg Microbes Infect 2022:1-15. Wang XY*, Mahmood SF, Jin F, Cheah WK, Ahmad M, Sohail MA, Ahmad W, Suppan VK, Sayeed MA, Luxmi S, Teo AH, Lee LY, Qi YY, Pei RJ, Deng W, Xu ZH, Yang JM, Zhang Y, Guan WX, Yu X. Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial. Emerg Microbes Infect 2022:1-44. Zhou HL, Chen LN, Wang SM, Tan M, Qiu C, Qiu TY, Wang XY*. Prevalence and Evolution of Noroviruses between 1966 and 2019, Implications for Vaccine Design. Pathogens 2021;10. Zhou HL, Bessey T, Wang SM, Mo ZJ, Barclay L, Wang JX, Zhang CJ, Ma JC, Qiu C, Zhao G, Li RC, Zhao YL, Jiang B, Wang XY*. Burden and etiology of moderate and severe diarrhea in children less than 5 years of age living in north and south of China: Prospective, population-based surveillance. Gut Pathog 2021;13:33. Wang JX, Chen LN, Zhang CJ, Zhou HL, Zhang YH, Zhang XJ, Hao ZY, Qiu C, Ma JC, Zhao YL, Zhong W, Tan M, Jiang X, Wang SM, Wang XY*. Genetic susceptibility to rotavirus infection in Chinese children: a population-based case-control study. Hum Vaccin Immunother 2021;17:1803-10. Chen Y, Zhao YL, Hao ZY, Zhang XJ, Ma JC, Zhang ZY, Zhang YH, Zhao G, Qiu C, Kilgore PE, Wang SM, Wang XY*. Long-term persistence of anti-HAV antibody conferred by a single dose of live-attenuated hepatitis A vaccine: Results from 17-year follow-up. J Viral Hepat 2021;28:1751-5. Wang JX, Zhou HL, Mo ZJ, Wang SM, Hao ZY, Li Y, Zhen SS, Zhang CJ, Zhang XJ, Ma JC, Qiu C, Zhao G, Jiang B, Jiang X, Li RC, Zhao YL, Wang XY*. Burden of viral gastroenteritis in children living in rural China: Population-based surveillance. Int J Infect Dis 2020;90:151-60. Wang XY, Wang B, Wen YM. From therapeutic antibodies to immune complex vaccines. NPJ vaccines 2019;4:2. Zhou X, Geng S, Zhang S, Zhao W, Zhao G, Wen Y, Wang X*, Wang B. Biomarkers distinguish HBeAg seroconverted from non-converted individuals in chronic hepatitis B patients treated with a therapeutic vaccine. Cytokine 2018;106:176-81. Wang XY, Wen YM. A "sandwich" strategy for functional cure of chronic hepatitis B. Emerging microbes & infections 2018;7:91. Chen Y, Zhou CL, Zhang XJ, Zhang YH, Hao ZY, Wang SM, Ma JC, Zhao G, Qiu C, Zhao YL, Wang B, Wang XY*. Immune memory at 17-years of follow-up of a single dose of live attenuated hepatitis A vaccine. Vaccine 2018;36:114-21. Zhou C, Li C, Gong GZ, Wang S, Zhang JM, Xu DZ, Guo LM, Ren H, Xu M, Xie Q, Pan C, Xu J, Hu Z, Geng S, Zhou X, Wang X, Zhou X, Mi H, Zhao G, Yu W, Wen YM, Huang L, Wang XY*, Wang B. Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients. Hum Vaccin Immunother 2017;30:1-8. Qiao N, Wang SM, Wang JX, Kang B, Zhen SS, Zhang XJ, Hao ZY, Ma JC, Qiu C, Zhao YL, Liu L, Wang XY. Variation analysis of norovirus among children with diarrhea in rural Hebei Province, north of China. Infect Genet Evol 2017;53:199-205. Li RC^, Liu LD^, Mo ZJ^, Wang XY^, Xia JL^, Zhang Y, Li YP, Mao Q, Wang J, Jiang L, Dong C, Che Y, Huang T, Jiang Z, Xie Z, Wang L, Liao Y, Liang Y, Nong Y, Liu J, Zhao H, Na R, Guo L, Pu J, Yang E, Sun L, Cui P, Shi H, Wang J, Li Q (2014) An inactivated enterovirus 71 vaccine in healthy children. N Engl J Med 370: 829-837. Xu DZ, Wang XY, Shen XL, Gong GZ, Ren H, Guo LM, Sun AM, Xu M, Li LJ, Guo XH, Zhen Z, Wang HF, Gong HY, Xu C, Jiang N, Pan C, Gong ZJ, Zhang JM, Shang J, Xu J, Xie Q, Wu TF, Huang WX, Li YG, Xu J, Yuan ZH, Wang B, Zhao K, Wen YM, for the YIC Efficacy Trial Study Team (2013) Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings. J Hepatol 59: 450-456. Wang XY, Yao X, Wan YM, Wang B, Xu JQ, Wen YM (2013) Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice. Immunol Lett 149: 88-92. Wang XY*, Riewpaiboon A, von Seidlein L, Chen XB, Kilgore PE, Ma JC, Qi SX, Zhang ZY, Hao ZY, Chen JC, ZY. X (2009) The potential cost-effectiveness of a rotavirus immunization program in rural China. Clin Infect Dis 49: 1202-1210. Wang XY*, Du L, Von Seidlein L, Xu ZY, Zhang YL, Hao ZY, Han OP, Ma JC, Lee HJ, Ali M, Han CQ, Xing ZC, Chen JC, Clemens J (2005) Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study. Am J Trop Med Hyg 73: 416-422. Lucas ME, Deen JL, von Seidlein L, Wang XY, Ampuero J, Puri M, Ali M, Ansaruzzaman M, Amos J, Macuamule A, Cavailler P, Guerin PJ, Mahoudeau C, Kahozi-Sangwa P, Chaignat CL, Barreto A, Songane FF, Clemens JD (2005) Effectiveness of mass oral cholera vaccination in Beira, Mozambique. N Engl J Med 352: 757-767. Xu ZY, Wang XY, Li RC, Meng ZD, Zhang Y, Gong J, Ma JC, Li YT, Zhao SJ, Li YP, Zhao YL, Huang QC, Luo D, Xia JL, Liu HB, Liu XL, Ouyang PY. [Immunogenicity and efficacy of two live attenuated hepatitis A vaccines (H(2) strains and LA-1 strains)]. Zhonghua Yi Xue Za Zhi 2002;82:678-81.

学术兼职

治疗性疫苗国家工程实验室副主任 国家免疫规划专家咨询委员会委员 国家药品监督管理局药品审评中心外聘专家 世界卫生组织免疫和疫苗相关实施研究咨询委员会委员(the Immunization and vaccines related implementation research advisory committee (IVIR-AC), Immunization, Vaccines and Biologicals (IVB), World Health Organization) 《Human Vaccines & Immunotherapeutics》副主编

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