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个人简介

教育经历 1995.09—2001.09 华中农业大学生物化学与分子生物学专业本硕连读生 2001.09—2004.07 中国医学科学院/北京协和医科大学病原生物学专业博士研究生 工作经历 2004.10—2012.2 美国宾夕法尼亚大学医学院博士后、助理研究员 2012.05—至今 复旦大学基础医学院 研究员,PI 2019.10—至今 基础医学院病原生物系、医学分子病毒学教育部/卫健委重点实验室 副主任 2020.10—至今 基础医学院共享仪器设备平台中心 主任 2021.04—至今 上海市重大传染病和生物安全研究院 双聘PI, 技术支撑中心 主任

研究领域

微环境与病毒(KSHV,EBV和HPV等)共诱发宿主细胞癌变机理及其靶向干预小分子药物和裂解肽的研发 缺氧微环境应激响应溶瘤病毒,基因递送系统的构建及其在不同瘤种治疗和疫苗应用研发 病毒急性(新冠)和慢性(疱疹)感染宿主关键限制性因子(蛋白修饰调控)的发现

近期论文

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Zhang S, Du S, Wang Y, Jia Y, Wei F, Zhang D, Cai Q, Zhu C. Rapid establishment of murine gastrointestinal organoids using mechanical isolation method. Biochem Biophys Res Commun. 2022 Jun 11;608:30-38. doi: 10.1016/j.bbrc.2022.03.151. Epub 2022 Mar 31. PMID: 35381426.2022-Zhang et al BBRC.pdf Banerjee S, Wang X, Du S, Zhu C, Jia Y, Wang Y, Cai Q. Comprehensive role of SARS-CoV-2 spike glycoprotein in regulating host signaling pathway. J Med Virol. 2022 Sep;94(9):4071-4087. doi: 10.1002/jmv.27820. Epub 2022 May 9. PMID: 35488404; PMCID: PMC9348444.2022-Shuvo et al-JMV.pdf Liu X, Zheng L, Wang T, Li Y, Wu B, Du S, Zhu Q, Zhu C, Wang Y, Zhang R, Wei F, Cai Q. A System Based on Novel Parainfluenza Virus PIV5-L for Efficient Gene Delivery of B-Lymphoma Cells.J Virol. 2022 Apr 27;96(8):e0025722. doi: 10.1128/jvi.00257-22. Epub 2022 Apr 4. PMID: 35373581; PMCID: PMC9044942.2022-Liu et al JVI.pdf Zhu G, Du S, Wang Y, Huang X, Hu G, Lu X, Li D, Zhu Y, Qu D, Cai Q, Liu L, Du M. Delayed Antiviral Immune Responses in Severe Acute Respiratory Syndrome Coronavirus Infected Pregnant Mice. Front Microbiol. 2022 Jan 21;12:806902. doi: 10.3389/fmicb.2021.806902. PMID: 35126335; PMCID: PMC8814454.2022-Du et al-Frontier Microb.pdf Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PMID: 33574281; PMCID: PMC7878750.2021-Zhu et al-NC.pdf Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q. Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANASIM-Associated Proteins in Hypoxia. mSystems. 2021 Dec 21;6(6):e0110921. doi: 10.1128/mSystems.01109-21. Epub 2021 Nov 2. PMID: 34726485; PMCID: PMC8562486.2021-Liu et al-mSystems.pdf Liu X, Zhu C, Wang Y, Wei F, Cai Q. KSHV Reprogramming of Host Energy Metabolism for Pathogenesis. Front Cell Infect Microbiol. 2021 May 12;11:621156. doi: 10.3389/fcimb.2021.621156. PMID: 34055662; PMCID: PMC8153180.2021-Liu et al-Frontier.pdf Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q. STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency. PLoS Pathog.2020 Mar 16;16(3):e1008447. doi: 10.1371/journal.ppat.1008447. PMID: 32176739; PMCID: PMC7105294.2020-Wang et al-PPA.pdf Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F, Wei F, Cai Q. Lactate Induces Production of the tRNAHis Half to Promote B-lymphoblastic Cell Proliferation. Mol Ther. 2020 Nov 4;28(11):2442-2457. doi: 10.1016/j.ymthe.2020.09.010. Epub 2020 Sep 6. PMID: 32966775; PMCID: PMC7647672.2020-Mo et al-Mol Ther.pdf Chen WL, Jin X, Wang M, Liu D, Luo Q, Tian H, Cai L, Meng L, Bi R, Wang L, Xie X, Yu G, Li L, Dong C, Cai Q, Jia W, Wei W, Jia L. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. JCI Insight. 2020 Feb 13;5(3):e131596. doi: 10.1172/jci.insight.131596. PMID: 32051337; PMCID: PMC7098789.2020-JCI insight.pdf Chunlei Wan, Jiahui Tai, Jie Zhang, Yi Guo, Qing Zhu, Ding Ling, Feng Gu, Jin Gan, Caixia Zhu, Yuyan Wang, Sijin Liu, Fang Wei and Qiliang Cai*.Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication[J].Cell Death and Disease (2019)10:392.DOI:10.1038/s41419-019-1624-z IF:5.72(PDF)2019-Wan et al-CDD.pdf Qing Zhu, Ling Ding, Zhenguo Zi,Shujun Gao, Chong Wang,Yuyan Wang,Caixia Zhu,Zhenghong Yuan, Fang Wei, Qiliang Cai*.Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis[J].Cell Reports,(2019),26, 3657–3671.DOI:10.1016/j.celrep.2019.02.106. IF:8.032(PDF)2019-Zhu et al-Cell Rep.pdf Gu F,Wang C,Wei F,Wang Y,Zhu Q,Ding L,Xu W,Zhu C,Cai C,Qian Z,Yuan Z,Robertson E,Cai Q*.STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus[J].PLoS Pathogens,(2018),14 (12): e1007416.DOI:10.1371/journal. ppat.1007416 IF:6.158(PDF)2018-Gu et al-PPA.pdf Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q*. Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth[J]. J Virol ,(2018) DOI: 10.1128/JVI.00033-18 IF:4.667 (PDF) Zhu C, Wang Y, Cai C, Cai Q*. Bacterial Infection and Associated Cancers. Adv Exp Med Biol, (2017). 1018: p. 181-191. DOI: 10.1007/978-981-10-5765-6_11 IF:1.881 (PDF) Liang Q, Wang K, Wang B*, Cai Q* HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3. Sci Rep,(2017). 7: p. 44705. DOI: 10.1038/srep44705 IF:4.259 (PDF) Zhu Q, Gu F, Zhu C, Wang Y, Wei F*, Cai Q* Interplay Between Microenvironmental Abnormalities and Infectious Agents in Tumorigenesis. Adv Exp Med Biol, (2017). 1018: p. 253-271. DOI: 10.1007/978-981-10-5765-6_16 IF:1.881 (PDF) Cai Q*, Yuan Z. Overview of Infectious Causes of Human Cancers. Adv Exp Med Biol, 2017. 1018: p. 1-9. DOI: 10.1007/978-981-10-5765-6_1 IF:1.881 (PDF) Wang Y, Banerjee S*, Ding L, Cai C, Wei F*, Cai Q* The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers[J]. Virol Sin, 2017. 32(5): p. 357-368. DOI: 10.1007/s12250-017-4081-9 (PDF) Wang C, Zhu C, Wei F, Gao S, Zhang L, Li Y, Feng Y, Tong Y, Xu J, Wang B, Yuan Z, Robertson ES, Cai Q*. Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency[J]. PLoS Pathogens,(2017),13(1):e1006124. doi: 10.1371/journal.ppat.1006124 影响因子IF: 7.003 *通讯作者(PDF) Gan J, Qiao N, Strahan R, Zhu C, Liu L, Verma SC, Wei F, Cai Q* Manipulation of ubiquitin/SUMO pathways in human herpesviruses infection. Reviews in medical virology.(2016) doi: 10.1002/rmv.1900. [Epub ahead of print] 影响因子IF:4.308 *通讯作者(PDF) Zhu C, Zhu Q, Wang C, Zhang L, Wei F, Cai Q*Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review). International journal of oncology.(2016) doi: 10.3892/ijo.2016.3633. 影响因子IF:3.018 *通讯作者(PDF) Mo X, Zhu C, Gan J, Wang C, Wei F, Gong W,Cai Q* Prevalence and correlates of Mycoplasma genitalium infection among prostatitis patients in Shanghai, China. Sexual health.(2016)doi: 10.1071/SH15155. [Epub ahead of print] 影响因子IF:1.225 *通讯作者(PDF) Wei F, Zhu Q, Ding L, Liang Q, Cai Q*Manipulation of the host cell membrane by human γ-herpesviruses EBV and KSHV for pathogenesis. Virologica Sinica. (2016) *通讯作者(PDF) Wang C, Wei F, Cai Q* Deregulation of IL-4/IL-13-induced STAT6 signaling in viral oncogenesis. Oncology Communications.(2015) 1:e1131. doi: 10.14800 *通讯作者(PDF) Wei F, Gan J, Wang C, Zhu C and Cai Q* Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA. Front. Microbiol. (2016) 7:334. doi: 10.3389/fmicb.2016.00334 影响因子IF: 3.989 *通讯作者(PDF) Wang C, Zhu C, Wei F, Zhang L, Mo X, Feng Y, Xu J, Yuan Z, Robertson E5, Cai Q*, Constitutive activation of IL-13/STAT6 contributes to KSHV-associated PEL cell proliferation and survival. Journal of Virology, (2015)[Epub ahead of print]. 影响因子IF: 5.4 *通讯作者(PDF) Gan J, Wang C, Jin Y, Guo Y, Xu F, Zhu Q, Ding L, Shang H, Wang J, Wei F,Cai Q*, Robertson ES . Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA. Proteomics,(2015)15(12):2023-37. 影响因子IF: 5.4 *通讯作者(PDF) Zhang L, Zhu C, Guo Y, Lu J, Qin J, Wang J, Verma SC, Shan H, Robertson ES, Cai Q* . Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-Jk. Journal of Virology, (2014) 88(12):6873-84. 影响因子IF: 5.4 *通讯作者(PDF) Cai Q*, Cai S, Zhu C, Verma SC, Choi JY, Robertson ES . A SUMO2-interacting motif within LANA is essential for KSHV latency. PLoS Pathogens, (2013) 9(10):e1003751. 影响因子IF: 9.2 *通讯作者(PDF) Cai Q*, Shuovomoy A, Cervini A, Lu J, Hislop AD, Dzeng R, Robertson ES . IRF4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation. PLoS Pathogens, (2013) 9(10):e1003750. 影响因子IF: 9.2 *通讯作者 (PDF) Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Robertson ES . Kaposi’s sarcoma herpesvirus upregulates Aurora A kinase to promote phosphorylation-dependent ubiquitylation of p53. PLoS Pathogens, (2012) 8(3): e1002566. 影响因子IF: 9.2 (PDF) Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES . Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS Pathogens, (2011) 7(12):e1002418. 影响因子IF: 9.2 (PDF) Cai Q, Verma SC, Choi JY, Ma M, Robertson ES . Kaposi’s sarcoma associated herpesvirus inhibites IL-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. Journal of Virology, (2010) 84(21):11134-11144. 影响因子IF: 5.4 (PDF) Cai Q, Verma SC, Kumar P, Ma M, Robertson ES . Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS ONE, (2010) 5(3): e9720. 影响因子IF: 4.4 Cai Q, Robertson ES . Ubiquitin/SUMO modification regulates VHL protein stability and nucleotyoplasmic shuttling. PLoS ONE,(2010) 5(9):e12636. 影响因子IF: 4.4 (PDF) Cai Q, Verma SC, Lu J, Robertson ES . Molecular biology of Kaposi’s sarcoma-associated herpesvirus and related oncogenesis.Advances in Virus Research, (2010) 78:87-142. 影响因子IF: 4.0(PDF) Cai Q, Murakami M, Si H, Robetson ES . A potential alpha-helix motif in theamino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia.Journal of Virology, (2007) 81(19):10413-23. 影响因子IF: 5.4 (PDF) Cai Q, Knight JS, Verma SC, Zald P, Robertson ES . EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of VHL and p53 tumor suppressors. PLoS Pathogens, (2006) 2(10): e116. 影响因子IF: 9.2 (PDF) Cai Q, Lan K, Verma SC, Si H, Lin D, Robertson ES . Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions. Journal of Virology, (2006) 80(16):7965-75. 影响因子IF: 5.4(PDF) Banerjee S, Lu J, Cai Q, Sun Z, Jha HC, Robertson ES . EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation. PLoS Pathogens. (2014) 14;10(8):e1004304 影响因子IF: 9.2 Banerjee S, Lu J, Cai Q, Saha A, Jha HC, Robertson ES . The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8. PLoS Pathogens, (2013) 9(5):e1003314. 影响因子IF: 9.2 Lu J, Verma SC, Cai Q, Saha A, Dzeng R, Robertson ES . The RBP-Jκ binding sites within the RTA Promoter Regulates KSHV Latent Infection and Proliferation. PLoS Pathogens, (2011) 8(1):e1002479. 影响因子IF: 9.2 Verma SC, Lu J, Cai Q, Kosiyatrakul S, McDowell M, Schildkraut CL, Robertson ES . Single molecule analysis of replicated DNA reveals the usage of mutiple KSHV genome regions for latent replication. PLoS Pathogens, (2011) 7(11):e1002365. 影响因子IF: 9.2 Saha A, Halder S, Upadhayay S, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES . EBNA3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathogens, (2011) 7(2):e1001275. 影响因子IF: 9.2

学术兼职

2021-今 中国微生物学会病毒专委会 委员 2019-今 中国人体健康促进会鼻咽癌专委会 副主任委员 2015-2021 中国病毒学会青委会 副主任委员 2014-今 中华医学会上海医学病毒分会 委员 2019-今 Frontier Cell Infect Microb副主编、Emerg Microb Infect编委

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