Siegel, Jay - 天津大学 - 药物科学与技术学院

个人简介

Jay S. Siegel received his Ph. D. from Princeton working with Kurt Mislow. He was a Swiss Universities Fellow at ETH Zurich, with Professor Jack. D. Dunitz, and NSF-CNRS postdoctoral fellow at the University of Louis Pasteur in Strasbourg with Jean-Marie Lehn. He began as Assistant Professor of Chemistry in 1986 at UCSD, was promoted to Associate Professor in 1992 and Full Professor in 1996. In 2003, he was appointed as Professor and co-director of the Organic chemistry institute of the University of Zurich (UZH) and Director of its laboratory for process chemistry research (LPF). He served as Dean of Studies and Head of the Research Council for the Faculty of Sciences at UZH. He moved to Tianjin University as Dean of Pharmaceutical Science and Technology (2013-) and also Life Science (2015-). He is Qianren Scholar and recipient of the ChineseNational Friendship Medal. Prof. Siegel was a US-NSF Presidential Young Investigator in 1988, an American Cancer Society Jr. Fellow in 1990, an Alfred P. Sloan Fellow in 1992, and an Arthur C. Cope Scholar by the ACS in 1998. He was elected fellow of the American Association for the Advancement of Science in 1998, and fellow of Royal Society of Chemistry in 2007. He was visiting professor at Princeton, Caltech, University of Basel, the Weizmann Institute and Tokyo Institute of Technology. He has served on numerous society, foundation and journal advisory boards often as president. He has run grant panels and award programs for the US-NSF, EU-ERC, France-ARES and IUF, Saudi Arabia-KAUST, RGC-Hong Kong and Switzerland. His research focuses on the area of molecular design and synthesis His specialty is structural chemistry and stereochemistry of supramolecular architectures.

研究领域

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory. Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

近期论文

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Room‐Temperature Multiple Phosphorescence from Functionalized Corannulenes: Temperature Sensing and Afterglow Organic Light‐Emitting Diode** Angewandte Chemie 2023-10-23 | Journal article DOI: 10.1002/ange.202309718 CONTRIBUTORS: Changfeng Si; Tao Wang; Abhishek Kumar Gupta; David B. Cordes; Alexandra M. Z. Slawin; Jay S. Siegel; Eli Zysman‐Colman Mono- and sym-pentahalogenated corannulenes: reaction optimization & purification by in process product analysis Reaction Chemistry & Engineering 2022 | Journal article DOI: 10.1039/D2RE00010E CONTRIBUTORS: Bokai Xu; Tianjian Guo; Jay Siegel Cooperative Weak Dispersive Interactions Actuate Catalysis in a Shape-Selective Abiological Racemase Journal of the American Chemical Society 2022-02-16 | Journal article DOI: 10.1021/jacs.1c11032 CONTRIBUTORS: Yujia Wang; Michel Rickhaus; Olivier Blacque; Kim K. Baldridge; Michal Juríček; Jay S. Siegel Thiophene fused indenocorannulenes: synthesis, variable emission, and exceptional chiral configurational stability Organic Chemistry Frontiers 2021 | Journal article DOI: 10.1039/D1QO00596K CONTRIBUTORS: Xiaoqi Tian; Suchaya Chaiworn; Jun Xu; Nicolas Vanthuyne; Kim K. Baldridge; Jay S. Siegel Enantiopure C5 Pentaindenocorannulenes: Chiral Graphenoid Materials Angewandte Chemie 2021-12 | Journal article DOI: 10.1002/ange.202109946 CONTRIBUTORS: Tianjian Guo; Ansu Li; Jun Xu; Kim K. Baldridge; Jay Siegel Enantiopure C5 Pentaindenocorannulenes: Chiral Graphenoid Materials Angewandte Chemie International Edition 2021-12 | Journal article DOI: 10.1002/anie.202109946 CONTRIBUTORS: Tianjian Guo; Ansu Li; Jun Xu; Kim K. Baldridge; Jay Siegel Frontispiece: Enantiopure C5 Pentaindenocorannulenes: Chiral Graphenoid Materials Angewandte Chemie International Edition 2021-12 | Journal article DOI: 10.1002/anie.202184962 CONTRIBUTORS: Tianjian Guo; Ansu Li; Jun Xu; Kim K. Baldridge; Jay Siegel Frontispiz: Enantiopure C5 Pentaindenocorannulenes: Chiral Graphenoid Materials Angewandte Chemie 2021-12 | Journal article DOI: 10.1002/ange.202184962 CONTRIBUTORS: Tianjian Guo; Ansu Li; Jun Xu; Kim K. Baldridge; Jay Siegel The chemistry of branched condensed phosphates Nature Communications 2021-09-10 | Journal article DOI: 10.1038/s41467-021-25668-3 CONTRIBUTORS: Tobias Dürr-Mayer; Danye Qiu; Verena B. Eisenbeis; Nicole Steck; Markus Häner; Alexandre Hofer; Andreas Mayer; Jay S. Siegel; Kim K. Baldridge; Henning J. Jessen Synthesis and Acidity of 5-(m-Terphenyl-2′-yl)-1H-tetrazoles: Evidence for an Enhanced Polar−π Effect Compared to Carboxylic Acids Journal of Medicinal Chemistry 2021-03-25 | Journal article DOI: 10.1021/acs.jmedchem.0c02147 CONTRIBUTORS: Brett C. Bookser; Quyen-Quyen Do; Yongsak Sritana-Anant; Kim K. Baldridge; Jay S. Siegel One‐Pot Domino Carbonylation Protocol for Aromatic Diimides toward n‐Type Organic Semiconductors Angewandte Chemie International Edition 2020-08-10 | Journal article DOI: 10.1002/anie.202003179 Part of ISSN: 1433-7851 Part of ISSN: 1521-3773 Generalized Analytic Approach for Determination of Multidimensional Franck–Condon Factors: Simulated Photoelectron Spectra of Polynuclear Aromatic Hydrocarbons Journal of Chemical Theory and Computation 2020-07-14 | Journal article DOI: 10.1021/acs.jctc.0c00274 CONTRIBUTORS: Tosaporn Sattasathuchana; Jay S. Siegel; Kim K. Baldridge An S10-Symmetric 5-Fold Interlocked [2]Catenane Journal of the American Chemical Society 2020-06-10 | Journal article DOI: 10.1021/jacs.0c03349 CONTRIBUTORS: Tanya K. Ronson; Yujia Wang; Kim Baldridge; Jay S. Siegel; Jonathan R. Nitschke Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives Toxicology Letters 2020-03 | Journal article DOI: 10.1016/j.toxlet.2019.12.012 Part of ISSN: 0378-4274 X-ray Crystallography and Unexpected Chiroptical Properties Reassign the Configuration of Haliclonadiamine Journal of the American Chemical Society 2020-02-12 | Journal article DOI: 10.1021/jacs.9b12926 CONTRIBUTORS: Hong-Bing Liu; Gregory H. Imler; Kim K. Baldridge; Robert D. O’Connor; Jay S. Siegel; Jeffrey R. Deschamps; Carole A. Bewley Fluorous Corannulenes: Ab initio Predictions and the Synthesis of sym‐Pentafluorocorannulene Angewandte Chemie 2020-01-20 | Journal article DOI: 10.1002/ange.201913878 CONTRIBUTORS: Xiaoqi Tian; Jun Xu; Kim K. Baldridge; Jay S. Siegel Fluorous Corannulenes: Ab initio Predictions and the Synthesis of sym‐Pentafluorocorannulene Angewandte Chemie International Edition 2020-01-20 | Journal article DOI: 10.1002/anie.201913878 CONTRIBUTORS: Xiaoqi Tian; Jun Xu; Kim K. Baldridge; Jay S. Siegel Innentitelbild: Fluorous Corannulenes: Ab initio Predictions and the Synthesis of sym‐Pentafluorocorannulene (Angew. Chem. 4/2020) Angewandte Chemie 2020-01-20 | Journal article DOI: 10.1002/ange.201915590 CONTRIBUTORS: Xiaoqi Tian; Jun Xu; Kim K. Baldridge; Jay S. Siegel Inside Cover: Fluorous Corannulenes: Ab initio Predictions and the Synthesis of sym‐Pentafluorocorannulene (Angew. Chem. Int. Ed. 4/2020) Angewandte Chemie International Edition 2020-01-20 | Journal article DOI: 10.1002/anie.201915590 CONTRIBUTORS: Xiaoqi Tian; Jun Xu; Kim K. Baldridge; Jay S. Siegel