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个人简介

教育经历 1997.09—2002.06 四川大学华西医学中心本科 2002.09—2005.06 四川大学华西医学中心硕士 2007.09—2010.06 复旦大学上海医学院博士 工作经历 2010.07—2012.08 复旦大学上海医学院博士后 2012.09—2013.11 复旦大学基础医学院讲师 2013.12—2019.11 复旦大学基础医学院副教授 2019.12—至今 复旦大学基础医学院教授 科研项目 2019,国家自然科学基金面上项目,“肾癌细胞Notch1信号活化分泌IL-6促进肿瘤相关巨噬细胞产生Galectin-9介导免疫逃逸的机制研究”,主持 2017,国家自然科学基金面上项目,“谷氨酰胺转运蛋白SLC1A5通过改造细胞外代谢微环境促进肿瘤相关巨噬细胞介导的肾癌耐药机制研究”,主持 2015,国家自然科学基金面上项目,“聚合梳蛋白EZH2介导的miR-let-7c表观遗传抑制通过PAK1激酶信号调控巨噬细胞分化的分子机制和功能研究”,主持 2012,国家自然科学基金青年基金项目,“SAP对狼疮性肾炎中巨噬细胞分化的调控作用及其机制”,主持

研究领域

巨噬细胞生物学:深入研究在自身免疫病和肿瘤发生过程中巨噬细胞异常重编程的分子机制及其功能意义,为开发靶向巨噬细胞异常重编程的免疫治疗策略奠定基础

近期论文

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Fei Y, Cao Y, Gu Y, Fang H, Chen Y, Wang J, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Li R*, Zhang H*, Zhang W*.Intratumoral Foxp3+RORγt+ T cell infiltration determines poor prognosis and immunoevasive contexture in gastric cancer patients. Cancer Immunol Immunother. 2022;71(1):1-11.(共同通讯作者,IF=6.968) Zhang H, Li R, Cao Y, Gu Y, Lin C, Liu X, Lv K, He X, Fang H, Jin K, Fei Y, Chen Y, Wang J, Liu H, Li H, Zhang H*, He H*, Zhang W*. Poor clinical outcomes and immunoevasive contexture in intratumoral IL10-producing macrophages enriched gastric cancer patients. Ann Surg. 2022; 275:e626-e635. (共同通讯作者,IF=12.969) Cao Y, He H, Li R, Liu X, Chen Y, Qi Y, Yu K, Wang J, Chen L, Zhang P, Lin C, Liu H, Zhang H, Li H, Shen Z, Huang H, Sun Y, Zhang W*, Qin J*, Xu J*. Latency-associated peptide identifies immunoevasive subtype gastric cancer with poor prognosis and inferior chemotherapeutic responsiveness. Ann Surg. 2022; 275: e163–e173. (共同通讯作者,IF=12.969) Xia S, Gu Y, Zhang H, Fei Y, Cao Y, Fang H, Wang J, Lin C, Zhang H, Li H, He H, Xu J, Li R*, Liu H*, Zhang W*. Immune inactivation by APOBEC3B enrichment predicts response to chemotherapy and survival in gastric cancer. Oncoimmunology. 2021; 10(1):1975386. (共同通讯作者,IF=8.11) Shi M, Gu Y, Jin K, Fang H, Chen Y, Cao Y, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Qin J, Li R*, Zhang H*, Zhang W*.CD47 expression in gastric cancer clinical correlates and association with macrophage infiltration. Cancer Immunol Immunother. 2021; 70(7):1831-1840. (共同通讯作者,IF=6.968) Liu Z, Zhou Q, Wang Z, Zhang H, Zeng H, Huang Q, Chen Y, Jiang W, Lin Z, Qu Y, Xiong Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang J*, Chang Y*, Zhang W*. Intratumoral TIGIT+ CD8+ T cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer. J Immunother Cancer. 2020; 8(2):e000978. (共同通讯作者,IF=13.751) Zhou Q, Qi Y, Wang Z, Zeng H, Zhang H, Liu Z, Huang Q, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Xu L, Dai B, Guo J, Zhu Y*, Zhang W*, Xu J*. CCR5 blockade inflames antitumor immunity in BAP1-mutant clear-cell renal cell carcinoma. J Immunother Cancer. 2020; 8(1):e000228. (共同通讯作者,IF=13.751) Hu B, Wang Z, Zeng H, Qi Y, Chen Y, Wang T, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*,Xu J*. Blockade of DC-SIGN+ tumor-associated macrophages reactivates antitumor immunity and improves immunotherapy in muscle-invasive bladder cancer. Cancer Res. 2020; 80(8):1707-1719. (共同通讯作者,IF=12.701 ) Liu X, Cao Y, Li R, Gu Y, Chen Y, Qi Y, Lv K, Wang J, Yu K, Lin C, Liu H, Zhang H, He H, Chen L, Zhang P, Shen Z, Qin J, Sun Y, Li H*, Huang H*, Zhang W*, Xu J*. Poor clinical outcomes of intratumoral dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin–positive macrophages associated with immune evasion in gastric cancer. Eur J Cancer. 2020; 128:27-37. (共同通讯作者,IF=9.162 ) Li R, Liu H, Cao Y, Wang J, Chen Y, Qi Y, Lv K, Liu X, Yu K, Lin C, Zhang H, He H, Li H, Chen L, Shen Z, Qin J, Zhang W*, Sun Y*, Xu J*. Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+ CD8+ T cells conferring favourable prognosis. Br J Cancer. 2020; 122(10):1525-1534. (共同通讯作者,IF=7.64) Zeng H, Liu Z, Wang Z, Zhou Q, Qi Y, Chen Y, Chen L, Zhang P, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*,Xu J*. Intratumoral IL22-producing cells define immunoevasive subtype muscle-invasive bladder cancer with poor prognosis and superior nivolumab responses. Int J Cancer. 2020; 146(2):542-552.(共同通讯作者,IF=7.396) Fang H, Li R, Gu Y, Fei Y, Jin K, Chen Y, Cao Y, Liu X, Lv K, Wang J, Yu K, Lin C, Liu H, Li H, He H, Zhang W*, Zhang H*, Shen Z*.Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response. Oncoimmunology. 2020; 9(1):1856468. (共同通讯作者,IF=8.11) Gu Y, Chen Y, Jin K, Cao Y, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Qin J, Li R*, Zhang H*, Zhang W*.Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.Oncoimmunology. 2020; 9(1):1844402. (共同通讯作者,IF=8.11) Huang Q, Zhou Q, Zhang H, Liu Z, Zeng H, Chen Y, Qu Y, Xiong Y, Wang J, Chang Y, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Z*, Bai Q*, Zhang W*.Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundance.Oncoimmunology. 2020; 9(1):1810489. (共同通讯作者,IF=8.11) Lin C, He H, Liu H, Li R, Chen Y, Qi Y, Jiang Q, Chen L, Zhang P, Zhang H, Li H, Zhang W*, Sun Y*, Xu J*. Tumor-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer. Gut. 2019; 68(10):1764-1773. (共同通讯作者,IF=23.059,ESI高被引论文) Wang JT, Li H, Zhang H, Chen YF, Cao YF, Li RC, Lin C, Wei YC, Xiang XN, Fang HJ, Zhang HY, Gu Y, Liu X, Zhou RJ, Liu H, He HY, Zhang WJ*, Shen ZB*, Qin J*, Xu JJ*. Intratumoral IL17-producing cells infiltration correlate with anti-tumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer. Ann Oncol. 2019; 30(2): 266-273. (共同通讯作者,IF=32.976) Fu Q, Xu L, Wang Y, Jiang Q, Liu Z, Zhang J, Zhou Q, Zeng H, Tong S, Qi Y, Hu B, Fu H, Xie H, Zhou L, Chang Y, Zhu Y, Dai B*, Zhang W*,Xu J*. Tumor-associated macrophage-derived IL-23 interlinks kidney cancer glutamine addiction with immune evasion. Eur Urol. 2019; 75(5): 752-763. (共同通讯作者,IF=20.096) Qi Y, Chang Y, Wang Z, Chen L, Kong Y, Zhang P, Liu Z, Zhou Q, Chen Y, Wang J, Bai Q, Xia Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Y*, Xu J*,Zhang W*. Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response. Cancer Immunol Immunother. 2019; 68(12):2067-2080. (共同通讯作者,IF=6.968) Jiang Q, Fu Q, Chang Y, Liu Z, Zhang J, Xu L, Zhu Y, Wang Y, Zhang W*,Xu J*. CD19(+) tumor-infiltrating B-cells prime CD4(+) T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer. Cancer Immunol Immunother. 2019; 68(1): 45-56. (共同通讯作者,IF=6.968) Cao Y, Liu H, Li H, Lin C, Li R, Wu S, Zhang H, He H*, Zhang W*, Xu J*. Association of O6-Methylguanine-DNA Methyltransferase Protein Expression With Postoperative Prognosis and Adjuvant Chemotherapeutic Benefits Among Patients With Stage II or III Gastric Cancer. JAMA Surg. 2017; 152(11): e173120. (共同通讯作者,IF=14.766) Wang J, Lin C, Li H, Li R, Wu Y, Liu H, Zhang H, He H, Zhang W*, Xu J*. Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefits in patients with gastric cancer. Oncoimmunology. 2017; 6(11): e1353858. (共同通讯作者,IF=8.11) Yang L, Liu Y, An H, Chang Y, Zhang W*, Zhu Y, Xu L, Xu J*. High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of Patients with Clear Cell Renal Cell Carcinoma. Ann Surg Oncol. 2016; 23(3): 1044-1052. (共同通讯作者,IF=5.344) Zhang W, Liu H, Liu W, Liu Y, Xu J*. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway. Cell Death Differ. 2015; 22(2): 287-297. (第一作者,IF=15.828) Fu Q, Chang Y, An H, Fu H, Zhu Y, Xu L, Zhang W*,Xu J*. Prognostic Value of Interleukin-6 and Interleukin-6 Receptor in Organ-Confined Clear-Cell Renal Cell Carcinoma: A 5-Year Conditional Cancer-Specific Survival Analysis. Br J Cancer. 2015; 113(11): 1581-1589. (共同通讯作者,IF=7.64) Liu Z, Liu Y, Xu L, An H, Chang Y, Yang Y, Zhang W*, Xu J*. P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma. Cancer Sci. 2015; 106(9): 1224-1231. (共同通讯作者,IF=6.716) Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S*. DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem. 2013; 288(19): 13534-13550. (第一作者,IF=5.157) Zhang W, Cai Y (co-first author), Xu W, Yin Z, Gao X, Xiong S*. AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol. 2013; 33(5): 925-937. (共同第一作者,IF=8.317) Zhang W, Xu W, Xiong S*. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol. 2011; 187(4): 1764-1777. (第一作者,IF=5.422) Chen M, Zhang W (co-first author), Xu W, Zhang F, Xiong S*. Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization. Mol Immunol. 2011; 48(12-13): 1532-1539. (共同第一作者,IF=4.407) Zhang W, Cai Y, Xu W, Xiong S*. C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA. Protein Cell. 2011; 2(8):672-679. (第一作者,IF=14.87) Zhang W, Xu W, Xiong S*. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol. 2010;184(11):6465-6478. (第一作者,IF=5.422)

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