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个人简介

教育经历 2000.09—2004.07 西安交通大学生物工程专业本科生 2005.09—2010.07 中国科学院动物研究所博士研究生 工作经历 2010.10—2012.07 德国亚琛工业大学医院博士后研究员 2012.08—2018.08 德国慕尼黑大学医院博士后研究员 2018.09—至今 复旦大学基础医学院青年研究员

研究领域

非编码RNA及RNA代谢在免疫细胞中的功能 心血管疾病的免疫病理学机制研究及干预

近期论文

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Jia Y, Cheng L, Yang J, Mao J, Xie Y, Yang X,Zhang X, Wang D, Zhao Z, Schober A, Wei Y*. miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):218-237. (co-corresponding author) He J, Zhu Y, Wang B, Yang P, Gu W, Liang B, Jiang F, Wang H, Wei Y*, Kang L. piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy. Cell Reports 2022; 39:110593. (co-corresponding author) Xie Y, Wei Y*. A Novel Regulatory Player in the Innate Immune System: Long Non-coding RNAs. Int. J. Mol. Sci. 2021; 22(17), 9535. *corresponding author. Wei Y*, Aging's Accomplice in Harming the Cardiovascular System microRNA-217. Arterioscler Thromb Vasc Biol. 2020; 40:2566–2568. *corresponding author Jia Y, Wei Y*. Modulators of MicroRNA Function in the Immune System. Int. J. Mol. Sci. 2020; 21(7): 2357. *corresponding author Karshovska E; Wei Y; Subramanian P; Mohibullah R; Gei?ler C; Baatsch I; PopalA; Corbalán-Campos J; Exner N; Schober A. HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383. Arterioscler Thromb Vasc Biol. 2020; 40 (3):583-596. Wei Y*, Gurung R, Corbalán-Campos J, Natarelli L, Exner N, Erhard F, Greulich F, Zhu M, Gei?ler C, Uhlenhaut NH, Zimmer R, Schober A*. Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism. Circulation. 2018; 138(18):2007-2020. *co-corresponding author. Wei Y, Zhu M, Schober A. Macrophage MicroRNAs asTherapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer. Int J Mol Sci. 2018;19(6): 1756. Natarelli L, Gei?ler C, Csaba G, Wei Y, Zhu M, di Francesco A, Hartmann P, Zimmer R, Schober A. miR-103 promotes endothelial maladaptation by targeting lncWDR59. Nat Commun. 2018;9(1):2645. Zhu M, Wei Y, Gei?ler C, Abschlag K,Corbalán Campos J, Hristov M, M?llmann J, Lehrke M, Karshovska E, Schober A. Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting Mafb. Diabetes. 2017; 66(12):3072-3084. Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci. 2017;74(2):359-372. Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci. 2016; 73(18): 3473-95. He J #, Chen Q#, Wei Y#, Jing F, Yang M, Hao S, Guo X, Chen D, Kang L. MicroRNA-276 promotes egg hatching synchrony by upregulating brm in locusts. Proc Natl Acad Sci U S A. 2016;113(3):584-9. #co-first author. Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun. 2016;7:10521. Wei Y, Zhu M, Corbalán-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(4):796-803. Wang Y, Jiang F, Wang H, Song T, Wei Y, Yang M, Zhang J, Kang L. Evidence for the expression of abundant microRNAs in the locust genome. Sci Rep. 2015;5:13608. Yang M#, Wei Y#, Jiang F#, Wang Y, Guo X, He J, Kang L. MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. PLoS Genet, 2014;10(2):e1004206. #co-first author. (Recommended in F1000Prime (http://f1000.com/prime/718293925)) Schober A#, Nazari-Jahantigh M#, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014;20(4):368-76. (Recommended in F1000Prime (http://f1000.com/prime/718293958)) Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-46. Wei Y#, Nazari-Jahantigh M#, Chan L, Zhu M, Heyll K, Corbalán-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation. 2013;127(15):1609-1619. #co-first author. Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. Microrna-126, -145, and -155: A therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol. 2013;33(3):449-454. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: The good and bad in micrornas. Am J Physiol Heart Circ Physiol. 2013;304(8):H1050-9. Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. Microrna-155 promotes atherosclerosis by repressing bcl6 in macrophages. J Clin Invest. 2012;122:4190-4202. Nazari-Jahantigh M, Wei Y, Schober A. The role of micrornas in arterial remodelling.Thromb Haemost 2012;107:611-618. Chen S, Yang P, Jiang F, Wei Y, Ma Z, Kang L. De novo analysis of transcriptomedynamics in the migratory locust during the development of phase traits. PLoS One. 2010;5(12):e15633. Wei Y, Chen S, Yang P, Ma Z, Kang L. Characterization and comparative profiling of the small rna transcriptomes in two phases of locust. Genome biology. 2009;10:R6.

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