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个人简介

教育经历 2002.09-2007.07 复旦大学基础医学院生理与病理生理学系,病理学与病理生理学专业,博士 2005.07-2007.05 美国弗吉尼亚联邦大学联合培养博士研究生 1997.09-2002.07 山西医科大学临床医学专业,医学学士 工作经历 2013.12-今 复旦大学基础医学院生理与病理生理学系,副教授 2013.06-2014.06 哈佛大学公共卫生学院,访问学者 2007.07-2013.12 复旦大学基础医学院生理与病理生理学系,讲师 获得奖项 2023年度复旦大学上海医学院“青年医学名师培育工程”资助 2020年参加上海医学院第三届课程思政教案大赛荣获一等奖 2019年获得复旦大学上海医学院MBBS项目青年教师英语授课比赛三等奖 2018年获得复旦大学青年教师教学比赛二等奖

研究领域

脂质小分子代谢物在维持肝肠稳态及消化器官间沟通中的生物学意义 药物性肝损伤

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xu D#, Ma R#, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N*, Li X*. Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells. Nat Commun. 2022 Jul 30;13(1):4428.(末位通讯) Zheng Y#, Sun W#, Shan C, Li B, Liu J, Xing H, Xu Q, Cui B, Zhu W, Chen J, Liu L, Yang T*, Sun N*, Li X*. -Hydroxybutyrate Inhibits Ferroptosis-mediated Pancreatic Damage in Acute Liver Failure through the Increase of H3K9bhb. Cell Rep. 2022 Dec. 20;41(12): 111847.(末位通讯) Zhang Y#, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X*, Chen W*. Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer. Cancer Lett. 2023 Jul 10:566:216244.(共同通讯) Li X, Zhi Y, Li J, Lei X, Ju Y, Zhang Y, Zheng Y, Kong X, Xue F, Zhong W, Chen X, Tang J*, Li X*, Mao Y*. Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice. Arch Toxicol. 2023 Jul;97(7):1979-1995.(共同通讯) Zheng Y#, Sun W#, Wang Z, Liu J, Shan C, He C, Li B, Hu X, Zhu W, Liu L, Lan F, Jiang C, Zhao C, Li X*, Sun N*. Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy. Research (Wash D C). 2022 Nov 2; 2022:9784081.(共同通讯) Niu B#, Lei X#, Xu Q#, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X*, Mao Y*, Li X*. Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. Cell Biol Toxicol. 2022 Jun;38(3):505-530.(末位通讯) Lei X#, Xu Q#, Li C#, Niu B, Ming Y, Li J, Tang Y, Li X, Tang J, Wu J, Ju Y, Yao L, Wang B, Miao Q, Zhong W, Zhi Y, Xu L, Li C*, Li X*, Mao Y*. Egr1 confers protection against acetaminophen induced hepatotoxicity via transcriptional upregulating of Acaa2. Int J Biol Sci. 2022 May 29;18(9):3800-3817. (共同通讯) Hong W#, Xu D#, Song X#, Niu B, Zhuang Z, Lu Y, Lei X, Ma R, Lu C, Sun N, Mao Y*, Li X*. Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice. J Nutr Biochem. 2021 Nov; 97:108803.(末位通讯) heng Y#, Cui B#, Sun W, Wang S, Huang X, Gao H, Gao F, Cheng Q, Lu L, An Y, Li X*, Sun N*. Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury. Int J Biol Sci. 2020 Feb 10;16(7):1166-1179. (共同通讯) Li C#, Ming Y#, Wang Z, Xu Q, Yao L, Xu D, Tang Y, Lei X, Li X*, Mao Y*. GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation. Cell Mol Life Sci. 2019 Jan;76(1):129-145. (共同通讯) Du X#, Xu Q#, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X*, Chen S*. HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression. Cell Death & Disease. 2019 Nov 18;10(12):873.(共同通讯) Tang Y#, Zhang J#, Li J#, Lei X, Xu D, Wang Y, Li C, Li X*, Mao Y*. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1293-1304.(共同通讯) Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X*, Li X*. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. Arch Toxicol. 2017 Jan;91(1):271-287. (末位通讯)

学术兼职

中国病理生理学会内分泌与代谢专业委员会委员 中国医药生物技术协会药物性肝损伤防治技术专业委员会委员 STTT, Metabolism-clinical and experimental, Cell Death and Disease, Science China Life Sciences、Journal of Molecular Cell Biology等杂志审稿人

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