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Yansong Ren, Jinbo Liu, Huijun Xu, Shun Wang, Shirui Li, Meng Xiang, and Sifeng Chen*. Knockout of integrin β1 in induced pluripotent stem cells accelerates skin-wound healing by promoting cell migration in extracellular matrix. Stem cell research & therapy. Accepted.
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., and Chen, S.(2020). Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey. Stem cell research & therapy 2020 Aug 3; 11(1):334. doi: 10.1186/s13287-020-01847-9.
Meng Lu#; Rong Xue#; Pingping Wang; Xiaokai Wang; Xiaoyu Tian; Yingying Liu; Shun Wang; Anfeng Cui; Jingxin Xie; Lili Le; Meng Zhao; Jing Quan; Ning Li; Dan Meng; Xinhong Wang; Ning Sun; Alex F. Chen; Meng Xiang*; Sifeng Chen*; Induced pluripotent stem cells attenuate chronic allogeneic vasculopathy in an integrin beta-1-dependent manner. American Journal of Transplantation (accepted, online), American Journal of Transplantation.
陈思锋.2019新型冠状病毒导致的致命肺渗漏的病理生理学机制和防治策略:兼论血透的应用与依据.《中国病理生理杂志》 2020,Vol.36（3）: 562-567.DOI: 10.3969/j.issn.1000-4718.2020.03.028
Meng Lu , Peng Lu , Ming Xu, Xiaokai Wang , Anfeng Cui , Yijun Li , Xinhong Wang , Dan Meng , Ning Sun , Meng Xiang, and Sifeng Chen. Enhanced wound healing promotion by immune response-free monkey autologous iPSCs and exosomes vs. their allogeneic counterparts. EBioMedicine. 2019 Apr;42:443-457.
Ruiting Sun, Yingying Liu, Meng Lu, Qianqian Ding, Pingping Wang, Heng Zhang, Xiaoyu Tian, Peng Lu, Dan Meng, Ning Sun, Meng Xiang, Sifeng Chen. ALIX Increases Protein Content and Protective Function of iPSC-derived Exosomes. J Mol Med (Berl). 2019 Jun;97(6):829-844.
Yang H, Wei L, Liu C, Zhong W, Li B, Chen Y, Han R, Zhuang J, Qu J, Tao H, Chen H, Xu C, Liang Q, Lu C, Qian R, Chen S, Wang W, Sun N. Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds. Acta Biomater. 2019 Feb 16. pii: S1742-7061(19)30128-X. doi: 10.1016/j.actbio.2019.02.024. [Epub ahead of print]
Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671.
Cui A, Xiang M, Xu M, Lu P, Wang S, Zou Y, Qiao K, Jin C, Li Y, Lu M, Chen AF, Chen S. VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury. Toxicol Lett. 2019 Mar 1;302:60-74. doi: 10.1016/j.toxlet.2018.11.002. Epub 2018 Nov 15.
Q. DING, R. SUN, P. WANG, H. ZHANG, M. XIANG,D. MENG, N. SUN, A. F. CHEN and S. CHEN. Protective effects of human induced pluripotent stem cell?derived exosomes on high glucose?induced injury in human endothelial cells. Expermental and Therapeutic Medicine 2018;15: 4791-4797
Zhu W, Zhao M, Mattapally S, Chen S, Zhang J. Ccnd2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: Remuscularization of injured ventricle. Circulation research. 2018;122:88-96
Zhan Y, Sun X, Li B, Cai H, Xu C, Liang Q, Lu C, Qian R, Chen S, Yin L, Sheng W, Huang G, Sun A, Ge J, Sun N. Establishment of a prkag2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells. J Mol Cell Cardiol. 2018;117:49-61
Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X, Li X. Upregulation of hydroxysteroid sulfotransferase 2b1b promotes hepatic oval cell proliferation by modulating oxysterol-induced lxr activation in a mouse model of liver injury. Archives of toxicology. 2017;91:271-287
Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N. Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem cell research & therapy. 2017;8:202
Zhang H, Xiang M, Meng D, Sun N, Chen S. Inhibition of myocardial ischemia/reperfusion injury by exosomes secreted from mesenchymal stem cells. Stem cells international. 2016;2016:4328362
Xie J, Li X, Meng D, Liang Q, Wang X, Wang L, Wang R, Xiang M, Chen S. Transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft. Immunology letters. 2016;176:105-113
Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N. Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials. 2016;105:52-65
Wang L, Xiang M, Liu Y, Sun N, Lu M, Shi Y, Wang X, Meng D, Chen S, Qin J. Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow. Biomicrofluidics. 2016;10:014106
Luan L, Xue R, Lu C, Cui A, Hou Y, Quan J, Xiang M, Wang X, Yuan W, Sun N, Meng D, Chen S. Anti-serum with anti-autoantibody activity decreases autoantibody-positive b lymphocytes and type 1 diabetes of female nod mice. Autoimmunity. 2016;49:21-30
Kang X, Wei X, Wang X, Jiang L, Niu C, Zhang J, Chen S, Meng D. Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating notch signaling. Scientific reports. 2016;6:33737
Kang X, Wei X, Jiang L, Niu C, Zhang J, Chen S, Meng D. Nox2 and nox4 regulate self-renewal of murine induced-pluripotent stem cells. IUBMB life. 2016;68:963-970
Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, Yin L, Qian R, Chen S, Ling Z, Sun N. The roles of mesp family proteins: Functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein & cell. 2015;6:553-561
Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D. Bach1 represses wnt/beta-catenin signaling and angiogenesis. Circulation research. 2015;117:364-375
Gao Y, Meng D, Sun N, Zhu Z, Zhao R, Lu C, Chen S, Hua L, Qian R. Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochemical and biophysical research communications. 2014;443:586-591
Xu Y, Yang X, Wang Z, Li M, Ning Y, Chen S, Yin L, Li X. Estrogen sulfotransferase (sult1e1) regulates inflammatory response and lipid metabolism of human endothelial cells via ppargamma. Molecular and cellular endocrinology. 2013;369:140-149
Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, Xiang M, Wang X, Yuan W, Chen A, Meng D, Chen S. Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Clinical and experimental pharmacology & physiology. 2013;40:626-634
Le LL, Li XY, Meng D, Liang QJ, Wang XH, Li N, Quan J, Xiang M, Jiang M, Sun J, Chen SF. Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. CNS neuroscience & therapeutics. 2013;19:963-968
Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X, Chen S, Yin L, Li X. Effect of estrogen sulfation by sult1e1 and papss on the development of estrogen-dependent cancers. Cancer science. 2012;103:1000-1009
Shang Z, Lu C, Chen S, Hua L, Qian R. Effect of h(2)s on the circadian rhythm of mouse hepatocytes. Lipids in health and disease. 2012;11:23
Meng D, Mei A, Liu J, Kang X, Shi X, Qian R, Chen S. Nadph oxidase 4 mediates insulin-stimulated hif-1alpha and vegf expression, and angiogenesis in vitro. PloS one. 2012;7:e48393
Xiang M, Gu Y, Zhao F, Lu H, Chen S, Yin L. Mast cell tryptase promotes breast cancer migration and invasion. Oncology reports. 2010;23:615-619
Huang J, Lu C, Chen S, Hua L, Qian R. Postnatal ontogenesis of clock genes in mouse suprachiasmatic nucleus and heart. Lipids in health and disease. 2010;9:22
Xu C, Lu C, Hua L, Jin H, Yin L, Chen S, Qian R. Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein e knockout mice. The Canadian journal of cardiology. 2009;25:473-479
Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM. Microrna-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clinical and experimental pharmacology & physiology. 2009;36:181-188
Wang XH, Chen SF, Jin HM, Hu RM. Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats. Life sciences. 2009;84:240-249
Ning Y, Xu L, Ren S, Pandak WM, Chen S, Yin L. Star overexpression decreases serum and tissue lipids in apolipoprotein e-deficient mice. Lipids. 2009;44:511-519
Ning Y, Bai Q, Lu H, Li X, Pandak WM, Zhao F, Chen S, Ren S, Yin L. Overexpression of mitochondrial cholesterol delivery protein, star, decreases intracellular lipids and inflammatory factors secretion in macrophages. Atherosclerosis. 2009;204:114-120
Hou L, Lu C, Huang Y, Chen S, Hua L, Qian R. Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein e knock-out atherosclerotic mice. Lipids in health and disease. 2009;8:60
Zhang X, Zhao F, Xu C, Lu C, Jin H, Chen S, Qian R. Circadian rhythm disorder of thrombosis and thrombolysis-related gene expression in apolipoprotein e knock-out mice. International journal of molecular medicine. 2008;22:149-153
Zhang W, Wang XH, Chen SF, Zhang GP, Lu N, Hu RM, Jin HM. Biphasic response of endothelial progenitor cell proliferation induced by high glucose and its relationship with reactive oxygen species. The Journal of endocrinology. 2008;197:463-470
Zhang W, Wang X, Jin H, Qian R, Zhang G, Chen S, Hu R. Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2008;57:571-576
Wang L, Zhou X, Zhou T, Ma D, Chen S, Zhi X, Yin L, Shao Z, Ou Z, Zhou P. Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. Journal of cancer research and clinical oncology. 2008;134:365-372
Zhou P, Zhi X, Zhou T, Chen S, Li X, Wang L, Yin L, Shao Z, Ou Z. Overexpression of ecto-5'-nucleotidase (cd73) promotes t-47d human breast cancer cells invasion and adhesion to extracellular matrix. Cancer biology & therapy. 2007;6:426-431
Zhi X, Chen S, Zhou P, Shao Z, Wang L, Ou Z, Yin L. Rna interference of ecto-5'-nucleotidase (cd73) inhibits human breast cancer cell growth and invasion. Clinical & experimental metastasis. 2007;24:439-448
Wang XH, Zhang GP, Jin HM, Chen SF. Dynamic changes in the expression of growth factor receptors in the myocardium microvascular endothelium after murine myocardial infarction. Chinese medical journal. 2007;120:485-490
Wang XF, Shao Y, Chen SW, Tian DZ, Huang GY, Huang Y, Yao T, Lu LM. Amelioration of cardiac function in chronic myocardial infarcted rats following administration of vector pcdna3.1am. Clinical and experimental pharmacology & physiology. 2007;34:861-865
Ning Y, Chen S, Li X, Ma Y, Zhao F, Yin L. Cholesterol, ldl, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bend.3). Biochemical and biophysical research communications. 2006;342:1249-1256
Chen SW, Wang XF, Shao Y, Xue H, Zhou L, Yao T, Lu LM. Similar effects on rat renal mesangial cells by expressing different fragments of adrenomedullin gene in vitro. Acta pharmacologica Sinica. 2005;26:845-85
Curtis LM, Chen S, Chen B, Agarwal A, Klug CA, Sanders PW. Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation technique. American journal of physiology. Renal physiology. 2008;295:F310-314
Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S. Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007;7:1112-1120
Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, Li Calzi S, Lach R, Hock TD, Chen B, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant MB, Agarwal A. Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. The Journal of experimental medicine. 2007;204:605-618
Chen S, Wasserfall C, Kapturczak MH, Atkinson M, Agarwal A. Freeze-thaw increases adeno-associated virus transduction of cells. American journal of physiology. Cell physiology. 2006;291:C386-392
Kapturczak MH, Chen S, Agarwal A. Adeno-associated virus vector-mediated gene delivery to the vasculature and kidney. Acta biochimica Polonica. 2005;52:293-299
Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:7251-7256
Chen S, Kapturczak M, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Campbell-Thompson M, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human gene therapy. 2005;16:235-247
Chen S, Sega M, Agarwal A. 'Lumen digestion' technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice. BioTechniques. 2004;37:84-86, 88-89
Chen S, Agarwal A, Glushakova OY, Jorgensen MS, Salgar SK, Poirier A, Flotte TR, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology : JASN. 2003;14:947-958
Mainwaring MG, Rimsza LM, Chen SF, Gomez SP, Weeks FW, Reddy V, Lynch J, May WS, Kahn S, Moreb J, Leather H, Braylan R, Rowe TC, Fieniewicz KJ, Wingard JR. Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (t-em) and correlation with topoisomerase ii levels. Leukemia & lymphoma. 2002;43:989-999
Chen S, Gomez SP, McCarley D, Mainwaring MG. Topotecan-induced topoisomerase iialpha expression increases the sensitivity of the cml cell line k562 to subsequent etoposide plus mitoxantrone treatment. Cancer chemotherapy and pharmacology. 2002;49:347-355
Chen S, Patel JM, Block ER. Angiotensin iv-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release. American journal of physiology. Lung cellular and molecular physiology. 2000;279:L849-856.
Chen SF, Fei X, Li SH. A new simple method for isolation of microvascular endothelial cells avoiding both chemical and mechanical injuries. Microvascular research. 1995;50:119-128
Chen SF, Ruan YJ. 1 alpha,25-dihydroxyvitamin d3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema. Pharmacology & toxicology. 1995;76:365-367
Chen SF. The effects of platelet activating factor and retinoic acid on the expression of elam-1 and icam-1 and the functions of neutrophils. Mediators of inflammation. 1995;4:103-106
Chen SF. 1 alpha, 25-dihydroxyvitamin d3 decreased icam-1 and elam-1 expressions on pulmonary microvascular endothelial cells and neutrophil motivation. The Journal of steroid biochemistry and molecular biology. 1995;52:67-70
Chen SF, Li SH, Ding FY. Three drugs inhibit phospholipase a2-induced high permeability of endothelial monolayers. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1994;15:299-302
Li SH, Fei X, Chen SF, Ding ZQ, Wu ZL. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1994;15:219-222
Chen SF, Li SH, Fei X, Wu ZL. Phospholipase a2-induced lung edema and its mechanism in isolated perfused guinea pig lung. Inflammation. 1990;14:267-273
陈思锋， 姜远英， 张凤斋， 朱铨英， 钟纪根， 张金山。 萎胃安对大鼠慢性萎缩性胃炎的预防和治疗作用。 药学实践杂志 1998.11.15; 16(6): 328-330。
Hu N, Chen SF and Yu B. The mechanisms of ET-1-induced lung edema. Chung Hua I Hsueh Tsa Chih (Chin J Med) 1996:76:694.
Li SH, Dong Y and Chen SF. The effects of phospholipase A2 on endotoxin-induced rat lung injury. Chin J Appl Physiol 1994; 10:105.
李少华, 董艳, 陈思锋, 丁自强, 吴中立。磷脂酶A2在内毒素致大鼠肺损伤的作用。中国应用生理学杂志 1994.05.28; 10(2): 105。
Chen SF and Li SH. leukocyte-endothelium adhesion decreases the permeability of microvascular endothelial monolayers. Chin J Physiol Sci 1993; 9(3):201. (in English)
Chen SF and Li SH. Leukocytes regulate platelet activating factor-induced lung injury in isolated perfused rat lungs. Chin J Physiol Sci 1993; 9(3):208. (in English).
陈思锋; 费侠; 李少华。血小板激活因子所致的大鼠肺损伤依赖于细胞外钙离子的存在。第二军医大学学报 1993; 14(4): 327-330。
Li SH, Zhang HH and Chen SF. Platelet activating factor mediates endotoxin-induced lung injury and its mechanism. J Med Coll PLA(Chinese Army) 1992; 7(4):374. (in English).
李少华， 陈思锋， 费侠，丁自强，吴中立。血小板激活因子在内毒素致狗急性肺损伤中的作用及其机理。第二军医大学学报 1992; 13(2): 111-115。
陈思锋。狗磷脂酶A2与白细胞活性的关系。基础医学与临床 1992; 12(5): 26-28。
Chen SF, Li SH and Wu ZL. Effects of platelet activating factor and SRI 63-441 on pulmonary vascular permeability and resistances in isolated perfused rat lungs. Chin J Physiol Sci 1991; 7(2):157. (in English).
陈思锋。用大鼠离体灌流肺测定肺血管通透性和血管阻力。中国应用生理学杂志 1991; 7(2): 155-157。
丁自强， 吴中立， 陈思锋。急性胰腺炎狗肺表面活性物质系统的损伤及其机理。第二军医大学学报 1990; 11(1): 10-14。
Ding ZQ, Wu ZL and Chen SF. pulmonary surfactant system defects and their mechanism in acute pancreatitis. Chin J Med 1989; 10(5):433 . (in English).
陈思锋， 吴中立， 丁自强， 王琪， 李少华。狗急性胰腺炎时磷脂酶A2的变化及其在急性肺损伤中的作用。第二军医大学学报 1989; 10(2): 105-109。
陈思锋， 吴中立。体液和组织磷脂酶A2的简便快速测定法。第二军医大学学报 1989; 10(3): 254-256。杨义力， 陈思锋。糖皮质激素对大鼠血清磷脂酶A2的张力性抑制。第二军医大学学报 1989; 10(1): 29-30,24。
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