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个人简介

教育经历 1995.09—2000.07 安徽医科大学临床医学专业本科生 2008.09—2012.07 复旦大学生物化学与分子生物学专业博士研究生 工作经历 2000.07—2008.10 复旦大学基础医学院助教 2008.11—2014.10 复旦大学基础医学院讲师 2014.11—2020.10 复旦大学基础医学院副教授,期间在德克萨斯医学中心访学 2020.11—至今 复旦大学基础医学院教授 获得奖项 2014,“Reach the world”award,国际血栓与止血协会ISTH 2002,上海医学科技二等奖,上海市医学会 科研项目 2021,上海市自然科学基金面上项目,“Baz蛋白调控血小板细胞骨架重构和活化的研究”,主持 2018,国家自然科学基金面上项目,“细胞极性蛋白Pard3在血小板中的表达和功能研究”,主持 2016,国家自然科学基金面上项目,“核受体FXR在无核血小板中的表达和功能”,主持 2012,国家自然科学基金青年项目,“P2Y12 受体激活抗血小板凋亡的机制研究”,主持

研究领域

血小板激活机制和抗血栓药物临床转化 肿瘤早期标志物筛选和治疗靶点临床转化 遗传性疾病发病和治疗靶点临床转化

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Fuing Chen#, Cheng Ni#, Xiaoxiao Wang#, Ruhong Cheng#, Chaolan Pan#, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang(通讯)*, Ming Li1,*and Zhirong Yao*. S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome. Embo Molecular Medicine. 2022; e14904. doi: 10.15252/emmm.202114904. IF=12 Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Z hang, Li; Hu, Xichun; Fu, Chaowei*; Zhang, Si(通讯)*; Chen, She* ; A plasma SNORD33 signature predicts pla tinum beneft in metastatic triple-negative breast cancer patients, Molecular Cancer, 2022, 21(1): 22. IF=27 Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meili ng; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi*; Zhang, Si(通讯)*; Hu, Liang* ; Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activa tion: a translational study, European Heart Journal, 2022, 00: 1-19. IF=30 Xinyi Liu, Yanjie Chen, Si Zhang (通讯)*& Ling Dong. Gut microbiota-mediated immunomodulation in tumor. Journal of Experimental & Clinical Cancer Research, 2021, 40(1): 1-20. IF=11 Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy mediated DNA damage mechanism. Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen*, Ruyi Xue* and Si Zhang(通讯)*. Journal of hematology & oncology (IF=11). 2021 ,14(8) 1-19 Si Zhang*(通讯), Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang* & Liang Hu*. SARS-CoV- 2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of hematology & oncology, 2020,13(1), 1-22. SCI; IF=11编辑评述,Faculty Opinions推荐(F1000) Pingping Dong,Xiaoxiao Wang,Longzi Liu,Wenqing Tang,Lijie Ma,Wenjiao Zeng,Shaoyang Sun,Li Zhang,Ningping ,Zhang,Xizhong Shen,Harry L.A. Janssen,Ling Dong*,Si Zhang*(通讯), She Chen* . Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma. Journal of Hepatology. 2020, 73(6), 1446-1459. SCI; IF=20.58 Si Zhang,Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen,Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding. Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis. Circulation, SCI; IF=23; 2015. 131(13):1160-70. 编辑评述 Liu, Xijun, Ruyi Xue, Caiting Yang, Jianxin Gu, She Chen*, and Si Zhang*(通讯). Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor–mediated suppression of the estrogen sulfotransferase SULT1E1. Journal of Biological Chemistry; 2018, 293(33): 12759-12769. SCI; IF=4.23; Yu Cai, Guanqun Huang, Lijie Ma, Ling Dong, She Chen, Xizhong Shen, Shuncai Zhang, Ruyi Xue*, Deqiang Sun*, Si Zhang*(通讯). Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. BBA-Molecular Cell Research; SCI; IF=4.2; (2018) 1865(2),297-308. Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Ling Dong*, Harry L. A. Janssen*, Si Zhang*(通讯). M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma. Journal of Cellular Biochemistry, 2020,121(4), 2828-2838. SCI; IF=4.23 Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Longzi Liu, Ling Dong*, Si Zhang*(通讯). CD86 /CD206 tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma. PeerJ, 2020, 8, e8458. SCI; IF=2.37 Huitong Peng, Hongyi Wu, Ge Zhang, Wei Zhang,Yifan Guo, Lin Chang, She Chen, Ruyi Xue*, and Si Zhang*(通讯). Expression and Clinical Prognostic Value of Platelet NLRP3 in Acute Coronary Syndrome. International Journal of General Medicine, 2020,13, 791. The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance. Yifan Guo, Lin Chang, Ge Zhang, Zhanyan Gao, Hao Lin, Yuting Zhang, Liang Hu, She Chen, Bing Fan, Si Zhang*(通讯)& Ruyi Xue*. Thrombosis Journal,2021,volume 19, Article number: 2 Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma. Ping Tao, Liang Hong, Wenqing Tang, Qun Lu, Yanrong Zhao, Si Zhang*(通讯), Lijie Ma* and Ruyi Xue*. Front. In Oncol, 2021

学术兼职

2021-今 Frontiers in pharmocology 客座副主编

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