当前位置: X-MOL首页全球导师 国内导师 › 吴飞珍

个人简介

教育经历 2006/09-2009/07,上海大学,生物电子中心,电子生物,博士 2003/09-2006/03,上海大学,生物电子中心,计算软件与理论,硕士 1996/09-2002/07,浙江大学,医学院,临床医学专业毕业,学士 国外学习经历 2015/09-2017/02,哈佛大学Dana-Farber研究所,访问学者(国家公派) 2009/11-2010/01,美国加州圣地亚哥分校/NIH/哈佛大学,访问学者 工作经历 2021/01-至今,复旦大学生物医学研究院,研究员 2013/01-2020/12,复旦大学生物医学研究院,副研究员 2009/09-2012/12,复旦大学生物医学研究院,助理研究员

研究领域

智能药学、生物信息学

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xiaoqiang Chai, Jianfei Guo, Ruizhao Dong, Xuan Yang, Chao Deng, Chuanyuan Wei, JiaJie Xu, Weiyu Han, Jiacheng Lu, Chao Gao, Dongmei Gao, Cheng Huang, Aiwu Ke, Shuangqi Li, Huanping Li, Yingming Tian, Zhongkai Gu, Shuxian Liu, Hang Liu, Qilong Chen, Feng Liu, Jian Zhou, Jia Fan, Guoming Shi,Feizhen Wu#, Jiabin Cai#. Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma.Clinical and translational medicine, 2021; 11(3) (#共同通讯作者,IF7.8) Dingailu Ma, Irfete S Fetahu, Mei Wang, Rui Fang, Jiahui Li, Hang Liu, Tobin Gramyk, Isabella Iwanicki, Sophie Gu, Winnie Xu, Li Tan,Feizhen Wu#, Yujiang G Shi#. The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease.Clinical Epigenetics, 27 August 2020(#共同通讯作者,IF5.028) Shuangqi Li*, Jiuxing Feng*,Feizhen Wu*#, Jiabin Cai, Xinyu Zhang, Haikun Wang, Irfete S Fetahu, Isabella Iwanicki, Dingailu Ma, Tao Hu, Hang Liu, Bingjie Wang, Guoming Shi#, Li Tan#, Yujiang Geno Shi#.TET2 promotes anti‐tumor immunity by governing G‐MDSCs and CD8+ T‐cell numbers.EMBO reports, 2020 (#共同一作且共同通讯作者,IF7.497) Wenjing Li*, Violetta Karwacki-Neisius*#, Chun Ma, Li Tan, Yang Shi,Feizhen Wu#and Yujiang Geno Shi#. Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.Nucleic Acids Research, 2020 (#共同通讯作者,IF11.501) Irfete S Fetahu, Dingailu Ma, Kimberlie Rabidou, Christian Argueta, Michael Smith, Hang Liu,Feizhen Wu#,Yujiang G Shi#. Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease. Science Advances2019; 5(8) (#共同通讯作者,IF13.116) Jin Li, Yan Li, Wei Li, Huaibing Luo, Yanping Xi, Shihua Dong, Gao M,Xu P,Zhang B,Liang Y,Zou Q,Hu X,Peng L,Zou D,Wang T,Yang H,Jiang C, Peng SL#,Wu Feizhen#,Yu WQ#. Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks.Genome Research.2019; 1(22) (#共同通讯作者,IF 11.093) Wenqi Xu?, Jiahui Li?, Bowen Rong, Hongjie Shen, Bin Zhao, Mei Wang, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo,Feizhen Wu#, Fei Lan#. DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation.Protein & Cell.2020 Feb;11(2):150-154 (#共同通讯作者,IF 10.164) Peng L,Li Y,Xi Y,Li W,Li J, Lv R, Zhang L,Zou Q, Dong S,Luo H,Wu Feizhen#,Yu W#. Methyl-CpG-binding domain protein 3-like 2 (MBD3L2) promotes Tet2 enzymatic activity for mediating 5mC oxidation.J Cell Sci2016 Jan 14. (#共同通讯作者,IF 4.7) Xu Y*,Wu Feizhen*, Tan L*, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, Min J, Nicholson T, Chen T, Xu G, Shi Y, et al.Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.Molecullar Cell2011;42(4):451-464. (*共同第一作者, IF15.584) Ke AW*, Shi GM*, Zhou J*,Wu Feizhen*, Ding ZB, Hu MY, Xu Y, Song ZJ, Wang ZJ, Wu JC, Bai DS, Li JC, Liu KD, Fan J. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.Hepatology2009;49(2):491-503.(*共同第一作者,IF 14.679) Devbhandari RP*, Shi GM*, Ke AW*,Wu Feizhen*, Huang XY, Wang XY, Shi YH, Ding ZB, Xu Y, Dai Z, Fan J, Zhou J. Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin beta1 complex in the progression of hepatocellular carcinoma.PLoS One2011;6(9):e24901. (*共同第一作者,IF 4.092) 部分其它署名的文章 Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang,Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi, Hongjie Shen. METTL3 regulates heterochromatin in mouse embryonic stem cells.Nature2021. Yangliu Song, Weicheng Chen, Zitong Huang, Guixiang Tian, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Feizhen Wu, Maoxiang Qian, Xiaojing Ma, Wei Sheng, Guoying Huang. A Non-coding HES1 Variant Predisposes Children to Congenital Heart Disease in Chinese Population.Frontiers in cell and developmental biology. 2021. Wu, D., Hu, D., Chen, H., Shi, G., Fetahu, I. S.,Wu Feizhen, Rabidou, K., Fang, R., …, Lan, F., Fan, J., Shi, Y., Shi, Y. G. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.Nature. 2018 Jul (IF 41.57) Ying Wang, Chao Yin, Zhidan Chen, Yang Li, Yan Zou, Xiang Wang, Yanpeng An,Feizhen Wu, Guoping Zhang, Chunjie Yang, Huiru Tang, Yunzeng Zou, Hui Gong. Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.Cell and tissue research.2019 Lian CG, Xu Y, Ceol C,Wu Feizhen, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, et al.Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.Cell2012;150(6):1135-1146. (IF 31.957) Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J,Wu Feizhen, He HH, Cui Q, Clark E, et al.Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.Cell2012;151(6):1200-1213. (IF 31.957) Dango S, Mosammaparast N, Sowa ME, Xiong LJ,Wu Feizhen, Park K, Rubin M, Gygi S, Harper JW, Shi Y. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.Mol Cell2011;44(3):373-384. (IF 14.178) Chen T, Huang Z, Wang L, Wang Y,Wu Feizhen, Meng S, Wang C. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages.Cardiovasc Res. 2009;83(1):131-139. (IF 5.8) Rajakumara E, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R,Wu Feizhen, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.Mol Cell2011;43(2):275-284. (IF 14.178) Chen S, Ma J,Wu Feizhen, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y. The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.Genes Dev2012;26(12):1364-1375. (IF 12.64) Tan L, Xiong L, Xu W,Wu Feizhen, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YG. Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method.Nucleic Acids Res2013;41(7):e84. (IF 10.16) Q. Gao, Y. J. Zhao, X. Y. Wang, W. J. Guo, S. Gao, L. Wei, J. Y. Shi, G. M. Shi, Z. C. Wang, Y. N. Zhang, Y. H. Shi, J. Ding, Z. B. Ding, A. W. Ke, Z. Dai,Wu Feizhen, H. Wang, Z. P. Qiu, Z. A. Chen, Z. F. Zhang, S. J. Qiu, J. Zhou, X. H. He and J. Fan.Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.Gastroenterology2014;146(5):1397-1407. (IF 18.39) Guo R, Zheng L, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P,Wu Feizhen, Hui J, Fu X, et al.BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.Mol Cell2014;56(2):298-310. (IF 14.178) Laurent B, Ruitu L, Murn J, Hempel K, Ferrao R, Xiang Y, Liu S, Garcia BA, Wu H,Wu Feizhen, Steen H, Shi Y. A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation.Mol Cell2015;57(6):957-970 (IF 14.178) Chun Ma, Violetta Karwacki-Neisius, Haoran Tang, Wenjing Li, Zhennan Shi, Haolin Hu, Wenqi Xu, Zhentian Wang, Lingchun Kong, Ruitu Lv, Zheng Fan, Wenhao Zhou, Pengyuan Yang,Wu Feizhen, Jianbo Diao, Li Tan, Yujiang Geno Shi, Fei Lan, Yang Shi.Nono, a bivalent domain factor, regulates Erk signaling and mouse embryonic stem cell pluripotency.Cell reports2016;17(4): 997-1007 (IF8.28) Xiao M, Li J, Li W, Wang Y,Wu Feizhen, Xi Y, Zhang L, Ding C, Luo H, Li Y, Peng L, Zhao L, Peng S, Xiao Y, Dong S, Cao J, Yu W. MicroRNAs activate gene transcription epigenetically as an enhancer trigger.RNA Biol.2016 Feb 6:1-9. (IF3.9) hen H,Xu W,Guo R,Rong B,Gu L,Wang Z,He C,Zheng L,Hu X,Hu Z,Shao ZM,Yang P,Wu Feizhen,Shi YG,Shi Y,Lan F. Suppression of Enhancer Overactivation by a RACK7 Histone Demethylase Complex.Cell.2016 Apr 7;165(2):331-42. (IF 31.957) Kong L, Tan L, Lv R, Shi Z, Xiong L,Wu Feizhen, Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y, Shi YG. A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands.Nucleic Acids Res.2016 Oct 14;44(18):8682-8692. (IF 10.16)

推荐链接
down
wechat
bug