黄海艳 - 复旦大学 - 基础医学院

个人简介

教育经历 2002.09 — 2005.07 复旦大学, 生物化学与分子生物学, 博士 1998.09 — 2001.07 中国医科大学, 临床药理学, 硕士 1993.09 — 1998-07 中国医科大学, 护理学, 学士工作经历 2012.12—至今复旦大学基础医学院生物化学与分子生物学系硕士生导师 2009.12—至今复旦大学基础医学院生物化学与分子生物学系副教授 2006.01—2009.11 复旦大学基础医学院生物化学与分子生物学系讲师科研项目 2021，国家自然科学基金面上项目，“脂肪组织赖氨酰氧化酶对非酒精性脂肪肝的作用研究”，主持 2018，国家自然科学基金面上项目，“赖氨酰氧化酶重塑脂肪组织炎症微环境的机制研究”，主持 2013，国家自然科学基金面上项目，“ADAMTS1改变细胞微环境对脂肪细胞定向的作用及机制”，主持 2012，国家自然科学基金面上项目，“EMT对间充质干细胞的募集和定向为前棕色脂肪细胞的作用及机制”，主持

研究领域

细胞微环境对多潜能干细胞定向分化和代谢综合征的作用研究脂肪组织与肝脏的对话研究

近期论文

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Qi-Xiang Ma#, Wen-Ying Zhu, Xiao-Chen Lu, Duo Jiang, Feng Xu, Jin-Tao Li, Lei Zhang, Ying-Li Wu, Zheng-Jun Chen, Miao Yin*, Hai-Yan Huang*, Qun-Ying Lei*. BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16. Nature Metabolism, DOI：10.1038/s42255-021-00520-6, 2022. Chun Xing#, Duo Jiang#, Yang Liu, Qiqun Tang, Haiyan Huang*. Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis. Genes & Diseases, 9, 140-150, 2022. Chen SZ#, Ning LF, Xu X, Jiang WY, Xing C, Jia WP, Chen XL, Tang QQ*, Huang HY*. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling. Cell Death Differ, 23(11), 1778-1791, 2016. Huang H#, Song TJ#, Li X, Hu L, He Q, Liu M, Lane MD, Tang QQ*. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A, 106(31), 12670-5, 2009 . Jiang WY#, Xing C#, Wang HW,Wang W, Chen SZ, Ning LF, Xu X, Tang QQ, Huang HY*. A Lox/CHOP-10 crosstalk governs osteogenic and adipogenic cell fate by MSCs. J Cell Mol Med, 22(10), 5097-5108, 2018. Huang HY#*, Zhang WT#, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Tang QQ*.RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem, 290(17), 11119-29, 2015. Chen SZ#, Xu X, Ning LF, Jiang WY, Xing C, Tang QQ, Huang HY*. miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase. Obesity, 23(12), 2445–2453, 2015. Huang HY#, Chen SZ, Zhang WT, Wang SS, Liu Y, Li X, Sun X, Li YM, Wen B, Lei QY, Tang QQ*. Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Res, 10(3), 278-87, 2013. Huang HY#, Hu LL#, Song TJ, Li X, He Q, Sun X, Li YM, Lu HJ, Yang PY, Tang QQ*. Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics, 10(1), M110.002691, 2011. Wang SS#, Huang HY*, Chen SZ, Li X, Liu Y, Zhang WT, Tang QQ*. Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. Int J Biochem Cell Biol, 45(8), 1825-32, 2013.