个人简介
教育经历
1992.09 - 1996.07 华东理工大学生物化学专业本科生
1999.09 - 2001.12 中科院上海生命科学研究院生物化学与分子生物学硕士研究生
2002.09 - 2008.05 中科院上海生命科学研究院生物化学与分子生物学博士研究生
工作经历
1996.07 - 1997.06 中科院上海生命科学研究院生物化学与细胞生物学研究所研究见习员
1997.07 - 2000.06 中科院上海生命科学研究院生物化学与细胞生物学研究所研究实习员
2000.07 - 2000.04 中科院上海生命科学研究院生物化学与细胞生物学研究所助理研究员
2008.05 - 2009.05 中科院上海生命科学研究院生物化学与细胞生物学研究所副研究员
2009.05 - 2013.03 美国耶鲁大学医学院博士后
2013.06 - 至今 复旦大学基础医学院生物化学和分子生物学系研究员
近期论文
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He, X.Y., Hua, Y., Li, Q., Zhu, W., Pan, Y., Yang, Y.L., Li, X.Y., Wu, M.X., Wang, J.Y., Gan, X.Q.* FNDC5/irisin facilitates muscle−adipose−bone connectivity through ubiquitination- dependent activation of runt-related transcriptional factors RUNX1/2. The Journal of Biological Chemistry. 298 (3): 1-17, 2022.
Hua, Y., Yang, Y.L., Li, Q., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q.* Oligomerization of Frizzled and low-density lipoprotein receptor-related protein 5/6 initiates intracellular signaling for the canonical WNT/β-catenin pathway. The Journal of Biological Chemistry. 293 (51): 19710-19724, 2018. ( > 33 citations)
Li, Q., Hua, Y., Yang, Y.L., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q.* T Cell Factor 7 (TCF7)/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of Wnt/b-catenin pathway. Molecular and Cellular Biology. 38 (7), e00562-17, 2018. (selected as ‘spotlight’, > 14 citations)
Zhu, W., He, X.Y., Hua, Y., Li, Q., Wang, J.Y., Gan. X.Q.* The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. The Journal of Biological Chemistry. 292 (27): 11178-11188, 2017. ( > 32 citations)
Gan. X.Q.,* Wang, J.Y., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M.I., Wu, D.Q. PRR5L degradation promotes mTORC2-mediated PKC- phosphorylation and cell migration downstream of G12. Nature Cell Biology. 14 (7): 686-696, 2012. ( > 145 citations)
Gan. X.Q.,* Wang, J.Y., Su, B., Wu, D.Q. Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphophate. The Journal of Biological Chemistry. 286 (13): 10998-11002, 2011. ( > 235 citations)
Gan. X.Q.,* Wang, J.Y., Xi, Y., Wu, Z.L., Li, Y.P., Li, L. Nuclear Dishevelled, c-Jun, -Catenin and TCF form a complex leading to stabilization of -catenin/TCF interaction. Journal of Cell Biology. 180 (6): 1087-1100, 2008. ( > 245 citations)