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个人简介

顾建新,复旦大学基础医学院生物化学与分子生物学系特聘教授,国家二级教授,复旦大学基础医学院基因研究中心主任,博士生导师。曾任中国生化与分子生物学学会常务理事、卫健委糖复合物重点实验室主任、全国复合糖专业委员会主任委员、国际糖复合物学会中国区代表。任国家自然科学基金委二审专家,Glycoconjugate Journal副主编。先后主持国家重点研发计划精准医学研究专项(首席科学家)、国家自然科学基金重点项目、国际合作项目、面上项目,负责 973 和两次国家传染病重大专项课题,并参与过 863 课题等。先后被评为教育部优秀人才、上海市科委优秀学科带头人和上海市曙光学者,享国务院特殊津贴。 教育经历 1983.9-1989.2日本名古屋大学 生物化学博士 工作经历 1989.3-1989.8日本大阪大学博士后 1991.9-1994.4上海医科大学(复旦大学基础医学院)生化系副教授 1994.5至今上海医科大学(复旦大学基础医学院)生化系教授

研究领域

肿瘤诊疗糖链标志物的发现和验证 O-GlcNAc糖基化修饰在肿瘤中的功能机制研究 糖链受体在肿瘤发生发展中的功能机制研究

近期论文

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Qin W, Zhang Z, Qin R, Han J, Zhao R, Gu Y, Pan Y, Gu J*, Ren S*. Providing Bionic Glycome as internal standards by glycan reducing and isotope labeling for reliable and simple quantitation of N-glycome based on MALDI- MS. Anal Chim Acta. 2019 Nov 12;1081:112-119. Xu L#, Liu F#, Li C, Li S, Wu H, Guo B, Gu J*, Wang L*. Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2. Glycobiology, 2020 Apr 20;30(5):301-311. Qin W, Zhang Z, Qin R, Han J, Zhao R, Gu Y, Pan Y, Gu J*, Ren S*. Providing Bionic Glycome as internal standards by glycan reducing and isotope labeling for reliable and simple quantitation of N-glycome based on MALDI- MS. Anal Chim Acta. 2019 Nov 12;1081: 112-119. Ren S (#), Zhang Z (#), Xu C, Guo L, Lu R, Sun Y, Guo J, Qin R, Qin W, Gu J*. Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types. Cell Research. 2016 Aug;26(8):963-6. Wang L (#), Yin J (#), Wang X (#), Shao M, Duan F, Wu W, Peng P, Jin J, Tang Y, Ruan Y*, Sun Y*, Gu J*,C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Gastroenterology. 2016 May;150(5):1183-1195. Wu Q,Liu H,Liu Y,Liu W,Pan D,Zhang W,Yang L,Fu Q,Xu J*,Gu J*,Decreased expression of hepatocyte nuclear factor 4alpha (Hnf4alpha)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity,Journal of Biological Chemistry,2015,290(2):1170-1185. Ruan Y,Sun L,Hao Y,Wang L,Xu J,Zhang W,Xie J,Guo L,Zhou L,Yun X,Zhu H,Shen A,Gu J*,Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma,Journal of Clinical Investigation,2012,122(7):2554-2566. Xu J (#),Liu H (#),Chen L,Wang Sh,Zhou L,Yun X,Sun L,Wen Y*,Gu J*,Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1,Gastroenterology,2012,143(1):199-212. Gu J,Development of glycoscience in China,Glycoconjugate Journal,2012,29(5-6):239-240. Liu H (#),Xu J (#),Zhou Lei,Yun X,Chen L,Wang Sh,Sun L,Wen Y*,Gu J*,Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating theSrc/PI3K/Akt pathway,Cancer Research,2011,71(24):7547-7575. Chi Y (#),Zhang Ch (#),Zong H,Hong Y,Kong X,Liu H,Zou W,Wang Y,Yun X,Gu J*,Identification of CDK11p58 Thr-370 Responsible for its Autophosphorylation, Dimerization and Kinase Activity,Journal of Biological Chemistry,2011,286(3):1748-1757. Xie J,Zhu H,Guo L,Ruan Y,Wang L,Sun L,Zhou L,Wu W,Yun X,Shen A*,Gu J*,Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway,The Journal of Immunology,2010,185(4):2306-2313. Xu J,Yun X,Jiang J,Wei Y,Wu Y,Zhang W,Liu Y,Wang W,Wen Y*,Gu J*,Hepatitis B virus X protein blunts senescence like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage,Hepatology,2010,52(1):142-154.

学术兼职

2010年,担任International Glycoconjugate Organization国际代表 2016年,中国生物工程学会糖生物工程专业委员会副主任委员 2021年,中国中国生物物理学会糖生物物理委员会 委员

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